Skip to main content

Advertisement

SpringerLink
Log in

Three synchronized neoplasms of the female genital tract: an extraordinary presentation

  • Case Report
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

We report a case of unusual co-existence of multiple primary neoplasms of female genital tract.

Case

A 62-year-old gravida 2, para 2 was referred with spotting and vaginal discharge for about 6 months. Fractionate curettage was performed and documented endocervical squamous cell carcinoma in situ. Subsequently total abdominal hysterectomy and bilateral salphingo-oophorectomy was performed. Final pathological report demonstrated cervical squamous cell carcinoma, right ovarian Brenner tumor, left ovarian granulosa tumor and endometrial polyps.

Discussion

Multiple primary neoplasms of female genital tract is a well-recognized yet rare occurrence. Although the presented case is probably an incidental event, the pathogenesis of the neoplastic process affecting the tissues with different embryological origin needs further research and evaluation. It is important to distinguish multiple primary neoplasms from metastatic disease because of the fact that overall survival as well as treatment would vary considerably.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Bichel P (1985) Simultaneous occurrence of a granulosa cell tumour and a serous papillary cystadenocarcinoma in the same ovary. A case report. Acta Pathol Microbiol Immunol Scand 93:175–181

    CAS  Google Scholar 

  2. Chen KT (1986) Female genital tract tumors in Peutz-Jeghers syndrome. Hum Pathol 17:858–861

    Article  PubMed  CAS  Google Scholar 

  3. Deligdisch L, Szulman AE (1975) Multiple and multifocal carcinomas in female genital organs and breast. Gynecol Oncol 3:181–190

    Article  PubMed  CAS  Google Scholar 

  4. Eifel P, Hendrickson M, Ross J, Ballon S, Mantinez A, Kempson R (1982) Simultaneous presentation of carcinoma involving the ovary and endometrium. Cancer 50:163–170

    Article  PubMed  CAS  Google Scholar 

  5. Isin Dogan Ekici A, Kucukali T, Coskun Salman M, Ayhan A (2006) Triple simultaneous primary gynecological malignancies in a 56-year-old patient. Int J Gynecol Cancer 16:1947–1950

    Article  PubMed  CAS  Google Scholar 

  6. Kaminski PF, Norris HJ (1984) Coexistence of ovarian neoplasms and endocervical adenocarcinoma. Obstet Gynecol 64:553–556

    PubMed  CAS  Google Scholar 

  7. Livolsi VA, Merino MJ, Schwartz PE (1983) Coexistent endocervical adenocarcinoma and mucinous adenocarcinoma of ovary: a clinicopathologic study of four cases. Int J Gynecol Pathol 1:391–402

    PubMed  CAS  Google Scholar 

  8. Mai KT, Yazdi HM, Bertrand MA, LeSaux N, Cathcart LL (1996) Bilateral primary ovarian squamous cell carcinoma associated with human papilloma virus infection and vulvar and cervical intraepithelial neoplasia. A case report with review of the literature. Am J Surg Pathol 20:767–772

    Article  PubMed  CAS  Google Scholar 

  9. Mangili G, Taccagni G, Garavaglia E, Carnelli M, Montoli S (2004) An unusual admixture of neoplastic and metaplastic lesions of the female genital tract in the Peutz-Jeghers Syndrome. Gynecol Oncol 92:337–342

    Article  PubMed  Google Scholar 

  10. Manolitsas TP, Lanham SA, Hitchcock A, Watson RH (1998) Synchronous ovarian and cervical squamous intraepithelial neoplasia: an analysis of HPV status. Gynecol Oncol 70:428–431

    Article  PubMed  CAS  Google Scholar 

  11. Matlock DL, Salem FA, Charles EH, Savage EW (1982) Synchronous multiple primary neoplasia of the upper female tract. Gynecol Oncol 13:271–277

    Article  PubMed  CAS  Google Scholar 

  12. McKenna M, Kenny B, Dorman G, McCluggage WG (2005) Combined adult granulosa cell tumor and mucinous cystadenoma of the ovary: granulosa cell tumor with heterologous mucinous elements. Int J Gynecol Pathol 24:224–227

    Article  PubMed  Google Scholar 

  13. Milano CT, Deppe G, Deligdisch L, Cohen CJ (1980) Multiple primary neoplasms of the upper female genital tract. Gynecol Oncol 9:120–124

    Article  PubMed  CAS  Google Scholar 

  14. Ozbey C, Erdogan G, Pestereli HE, Simsek T, Karaveli S (2005) Serous papillary adenocarcinoma and adult granulosa cell tumor in the same ovary. An unusual case. APMIS 113:713–715

    Article  PubMed  Google Scholar 

  15. Papageorgiou T, Stratakis CA (2002) Ovarian tumors associated with multiple endocrine neoplasias and related syndromes (Carney complex, Peutz-Jeghers syndrome, von Hippel-Lindau disease, Cowden’s disease). Int J Gynecol Cancer 12:337–347

    Article  PubMed  CAS  Google Scholar 

  16. Price A, Russell P, Elliott P, Bannatyne P (1990) Composite mucinous and granulosa-cell tumor of ovary: case report of a unique neoplasm. Int J Gynecol Pathol 9:372–378

    Article  PubMed  CAS  Google Scholar 

  17. Ree YS, Cho SH, Kim SR, Cho SH, Kim KT, Park MH (2003) Synchronous primary endometrial and ovarian cancer with three different histologic patterns: a case report. Int J Gynecol Cancer 13:678–682

    Article  PubMed  Google Scholar 

  18. Saraiva J, Cunha F, Passos MJ, Dos Reis IS, Francisca A, Pereira A, Cabral I, Retto H (1995) Primary malignant neoplasms of the female genitalia. Acta Med Port 8:585–588

    PubMed  CAS  Google Scholar 

  19. Seldenrijk CA, Willig AP, Baak JP, Kuhnel R, Rao BR, Burger CW, van der Harten JJ, Dijkhuizen GH, Meijer CJ (1986) Malignant Brenner tumor. A histologic, morphometrical, immunohistochemical, and ultrastructural study. Cancer 58:754–760

    Article  PubMed  CAS  Google Scholar 

  20. Shimada M, Kigawa J, Nishimura R, Yamaguchi S, Kuzuya K, Nakanishi T, Suzuki M, Kita T, Iwasaka T, Terakawa N (2006) Ovarian metastasis in carcinoma of the uterine cervix. Gynecol Oncol 101:234–237

    Article  PubMed  Google Scholar 

  21. Song SH, Lee JK, Saw HS, Choi SY, Koo BH, Kim A, Yeom BW, Kim I (2006) Peutz-Jeghers Syndrome with multiple genital tract tumors and breast cancer: a case report with a review of literatures. J Korean Med Sci 21:752–757

    PubMed  Google Scholar 

  22. Stiller RJ, Gondos B, Hoffman JS, O’Regan PT, Curry SL (1986) Multiple primary neoplasms of the female genital tract. Conn Med 50:649–651

    PubMed  CAS  Google Scholar 

  23. Waxman M, Damjanov I, Alpert L, Sardinsky T (1981) Composite mucinous ovarian neoplasms associated with Sertoli–Leydig and carcinoid tumors. Cancer 47:2044–2052

    Article  PubMed  CAS  Google Scholar 

  24. Westerman AM, Wilson JH (1999) Peutz-Jeghers syndrome: risks of a hereditary condition. Scand J Gastroenterol Suppl 230:64–70

    Article  PubMed  CAS  Google Scholar 

  25. Woodruff JD, Julian CG (1969) Multiple malignancy in the upper genital tract. Am J Obstet Gynecol 103:810–822

    PubMed  CAS  Google Scholar 

  26. Yang SW, Cho MY, Jung SH, Lee KG, Cha DS, Kim KR (2001) Mucinous cystadenoma coexisting with stromal tumor with minor sex-cord elements of the ovary: a case report. J Korean Med Sci 16:237–240

    PubMed  CAS  Google Scholar 

  27. Young RH, Scully RE (1988) Mucinous ovarian tumors associated with mucinous adenocarcinomas of the cervix. A clinicopathological analysis of 16 cases. Int J Gynecol Pathol. 7:99–111

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Obstetrics and Gynecology Department, Marmara Univestiy, Istanbul, Turkey

    Tanju Pekin, Pinar Yoruk & Begüm Yıldızhan

  2. Obstetrics and Gynecology Department, Göztepe SSK Hospital, Istanbul, Turkey

    Recep Yıldızhan

  3. Marmara Pathology Center, Istanbul, Turkey

    Saime Ramadan

  4. Tophanelioğlu cd. Köşk sitesi. A/1 bl. No:16, Koşuyolu, 34662, Istanbul, Turkey

    Pinar Yoruk

Authors
  1. Tanju Pekin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pinar Yoruk
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Recep Yıldızhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Begüm Yıldızhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Saime Ramadan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pinar Yoruk.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pekin, T., Yoruk, P., Yıldızhan, R. et al. Three synchronized neoplasms of the female genital tract: an extraordinary presentation. Arch Gynecol Obstet 276, 541–545 (2007). https://doi.org/10.1007/s00404-007-0379-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-007-0379-4

Keywords

Search

Navigation