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Immunosuppression by ultraviolet B rays via eyes in mice

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Abstract Irradiation by ultraviolet B (UV-B; 280–320 nm) initiates suppression of contact hypersensitivity. Immunosuppression was induced in C57BL/6N Crj mice by exposure of the dorsal skin or the eyes to a 10 kJ/m2 dose of UV-B radiation from 20SE sunlamps, followed by sensitization with 0.5% fluorescein isothiocyanate (FITC). The degree of immunosuppression induced by UV-B eye irradiation was equal to that induced by UV-B skin irradiation. When mice were irradiated with UV-B into the eyes after the optic nerve had been cut, systemic immunosuppression was not induced.

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Authors and Affiliations

  1. Research Institute, Nippon Menard Cosmetic Co. Ltd., 2-7 Torimi-cho, Nishi-ku, Nagoya 451, Japan Tel. +81-52-531-6269; Fax +81-52-531-6277, , , , , , JP

    K. Hiramoto, Yukiko Mashita, Tomonori Katada & Hiroaki Konishi

  2. Department of Dermatology, Nagoya University Branch Hospital, 1-1-20 Daikominami, Higashi-ku, Nagoya 453, Japan, , , , , , JP

    Mariko Sugiura & Ritsuko Hayakawa

Authors
  1. K. Hiramoto
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  2. Yukiko Mashita
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  3. Tomonori Katada
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  4. Hiroaki Konishi
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  5. Mariko Sugiura
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  6. Ritsuko Hayakawa
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Received: 1 April 1997

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Hiramoto, K., Mashita, Y., Katada, T. et al. Immunosuppression by ultraviolet B rays via eyes in mice. Arch Dermatol Res 289, 709–711 (1997). https://doi.org/10.1007/s004030050266

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  • DOI: https://doi.org/10.1007/s004030050266

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