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Plasma oxidation status and antioxidant capacity in psoriatic children

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Abstract

Psoriasis, a chronic inflammatory skin disease, is associated with oxidative stress of serum lipoproteins. In psoriatic children we evaluated the activity and levels of myeloperoxidase, the activity of paraoxonase-1 (PON1) and biochemical markers of lipid peroxidation, to investigate wether an unbalance between oxidant–antioxidants occurs very early in psoriasis. A total of 52 patients affected by psoriasis and 48 sex–age-matched healthy controls were enrolled. Serum MPO levels were measured using ELISA method. MPO and PON1 activities (paraoxonase, arylesterase and lactonase) were evaluated by spectroscopic methods. Our results demonstrated a significant increase of MPO levels and activity in psoriatic subjects. PON1 activities were found to be significantly decreased. A positive correlation has been established between the MPO/PON1 ratio and levels of lipid peroxides in all psoriatic patients. These results suggest that an unbalance between MPO and PON1 can reflect in higher oxidative stress in serum lipoproteins.

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References

  1. JM Crow 2012 Psoriasis uncovered Nature 492 7429 S50 S51

    Article  Google Scholar 

  2. M Augustin G Glaeske MA Radtke E Christophers K Reich I Schäfer 2010 Epidemiology and comorbidity of psoriasis in children Br J Dermatol 162 3 633 636

    Article  CAS  Google Scholar 

  3. IM Miller C Ellervik S Yazdanyar GB Jemec 2013 Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors J Am Acad Dermatol 69 6 1014 1024

    Article  Google Scholar 

  4. G Ferretti R Alleva M Taus O Simonetti B Cinti A Offidani G Bossi G Curatola 1994 Abnormalities of plasma lipoprotein composition and fluidity in psoriasis Acta Dermato Venereol 74 3 171 175

    CAS  Google Scholar 

  5. C Koebnick M-H Black N Smith JK Der-Sarkissian AH Porter SJ Jacobsen 2011 The association of psoriasis and elevated blood lipids in overweight and obese children J Pediatrics 159 4 577 583

    Article  CAS  Google Scholar 

  6. O Simonetti G Ferretti A Salvi A Offidani G Bossi 1992 Plasma lipid changes in psoriatic children Dermatology 185 2 96 100

    Article  CAS  Google Scholar 

  7. A Pietrzak A Michalak-Stoma G Chodorowska JC Szepietowski 2010 Lipid disturbances in psoriasis: an update MediatInflamm 2010 535 612

    Google Scholar 

  8. B Vanizor Kural A Orem G Cimsit YE Yandi M Calapoglu 2003 Evaluation of the atherogenic tendency of lipids and lipoprotein content and their relationships with oxidant-antioxidant system in patients with psoriasis Clin Chim Acta 328 1–2 71 82

    Article  CAS  Google Scholar 

  9. M Matoshvili A Katsitadze T Sanikidze D Tophuria A Richetta S D'Epiro 2014 Alterations of redox-status during psoriasis Georgian Med News 232–233 60 64

    Google Scholar 

  10. C Yazici K Kose S Utas E Tanrikulu N Taslidere 2016 A novel approach in psoriasis: first usage of known protein oxidation markers to prove oxidative stress Arch Dermatol Res 308 3 207 212

    Article  CAS  Google Scholar 

  11. G Ferretti T Bacchetti A Campanati O Simonetti G Liberati A Offidani 2012 Correlation between lipoprotein(a) and lipid peroxidation in psoriasis: role of the enzyme paraoxonase-1 Br J Dermatol 166 1 204 207

    Article  CAS  Google Scholar 

  12. AM Offidani G Ferretti M Taus O Simonetti N Dousset P Valdiguie G Curatola G Bossi 1994 Lipoprotein peroxidation in adult psoriatic patients Acta Dermato Venereol 186 38 40

    CAS  Google Scholar 

  13. A Orem G Cimsit O Deger C Orem B Vanizor 1999 The significance of autoantibodies against oxidatively modified low-density lipoprotein (LDL) in patients with psoriasis Clin Chim Acta 284 1 81 88

    Article  CAS  Google Scholar 

  14. NS Tekin O TekinI F Barut EY Sipahi 2007 Accumulation of oxidized low-density lipoprotein in psoriatic skin and changes of plasma lipid levels in psoriatic patients Mediators Inflamm 2007 78454

    PubMed  Google Scholar 

  15. MJ Paiva-Lopes J Delgado Alves 2017 Psoriasis-associated vascular disease: the role of HDL J Biomed Sci 24 1 73

    Article  Google Scholar 

  16. M Holzer P Wolf S Curcic R Birner-Gruenberger W Weger M Inzinger D El-Gamal C Wadsack A Heinemann C Marsche 2012 Psoriasis alters HDL composition and cholesterol efflux capacity JLipid Res 53 8 1618 1624

    Article  CAS  Google Scholar 

  17. M Holzer P Wolf M Inzinger M Trieb S Curcic L Pasterk W Weger MA Heinemann G Marsche 2014 Anti-psoriatic therapy recovers high-density lipoprotein composition and function J Invest Dermatol 134 3 635 642

    Article  CAS  Google Scholar 

  18. L He S Qin L Dang G Song S Yao N Yang 1841 Li Y (2014) Psoriasis decreases the anti-oxidation and anti-inflammation properties of high-density lipoprotein Biochim Biophys Acta 12 1709 1715

    Google Scholar 

  19. M Mackness B Mackness 2015 Human paraoxonase-1 (PON1): Gene structure and expression, promiscuous activities and multiple physiological roles Gene 567 1 12 21

    Article  CAS  Google Scholar 

  20. T Bacchetti A Campanati G Ferretti O Simonetti G Liberati A Offidani 2013 Oxidative stress and psoriasis: the effect of antitumour necrosis factor- inhibitor treatment Br J Dermatol 168 5 984 989

    Article  CAS  Google Scholar 

  21. JW Heinecke 1999 Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory disorders J Lab Clin Med 133 4 321 325

    Article  CAS  Google Scholar 

  22. RL Zhang ML Brennan ZZ Shen JC MacPherson D Schmitt CE Molenda SL Hazen 2002 Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation J Biol Chem 277 48 46116 46122

    Article  CAS  Google Scholar 

  23. Y Haraguchi R Toh M Hasokawa H Nakajima T Honjo K Otsui K Mori M Miyamoto-Sasaki M Shinohara K Nishimura T Ishida K Hirata 2014 Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease Atherosclerosis 234 2 288 294

    Article  CAS  Google Scholar 

  24. BX Ou M Hampsch-Woodill RL Prior 2009 Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe J Agric Food Chem 49 10 4619 4626

    Article  Google Scholar 

  25. W Rock M Rosenblat R Miller-Lotan AP Levy M Elias M Aviram 2008 Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities J Agric Food Chem 56 18 8704 8713

    Article  CAS  Google Scholar 

  26. G Ferretti T Bacchetti A Campanati O Simonetti G Liberati A Offidani 2012 Correlation between lipoprotein(a) and lipid peroxidation in psoriasis: role of the enzyme paraoxonase-1 Br J Dermatol 166 204 207

    Article  CAS  Google Scholar 

  27. L He S Qin L Dang G Song S Yao N Yang Y Li 2014 Psoriasis decreases the anti-oxidation and anti-inflammation properties of high-density lipoprotein Biochim Biophys Acta 1841 12 1709 1715

    Article  CAS  Google Scholar 

  28. E Attwa E Swelam 2011 Relationship between smoking-induced oxidative stress and the clinical severity of psoriasis J Eur Acad Dermatol Venereol 25 7 782 787

    Article  CAS  Google Scholar 

  29. SD Pektas G Akoglu A Metin S Neselioglu O Erel 2013 Evaluation of systemic oxidant/antioxidant status and paraoxonase 1 enzyme activities in psoriatic patients treated by narrow band ultraviolet B phototherapy Redox Rep 18 5 200 204

    Article  CAS  Google Scholar 

  30. JO Baek D Byamba WH Wu TG Kim MG Lee 2012 Assessment of an imiquimod-induced psoriatic mouse model in relation to oxidative stress Arch Dermatol Res 304 9 699 706

    Article  CAS  Google Scholar 

  31. A Pietrzak M Kozioł-Montewka B Lecewicz-Toruń D Krasowska 2000 Is there any correlation between the total number of neutrophils in plasma and concentration of interleukin-8 in psoriatic patients? Med Sci Monit 6 867 870

    CAS  PubMed  Google Scholar 

  32. N Dilek AR Dilek Y Taskin T Erkinuresin O Yalcin Y Saral 2006 Contribution of myeloperoxidase and inducible nitric oxide synthase to pathogenesis of psoriasis Postepy Dermatolologii i Alergologii 33 6 435 439

    Google Scholar 

  33. L Zheng B Nukuna ML Brennan M Sun M Goormastic M Settle D Schmitt X Fu L Thomson PL Fox H Ischiropoulos JD Smith M Kinter SL Hazen 2004 Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease JClin Invest 114 4 529 541

    Article  CAS  Google Scholar 

  34. DQ Peng Z Wu G Brubaker L Zheng M Settle E Gross M Kinter SL Hazen JD Smith 2005 Tyrosine modification is not required for myeloperoxidase-induced loss of apolipoprotein A-I functional activities J Biol Chem 280 40 33775 33784

    Article  CAS  Google Scholar 

  35. Y Huang ZP Wu M Riwanto SQ Gao BS Levison X Gu X Fu MA Wagner C Besler G Gerstenecker R Zhang XM Li AJ Donato Di V Gogonea WH Tang JD Smith EF Plow PL Fox DM Shih AJ Lusis EA Fisher JA DiDonato U Landmesser SL Hazen 2013 Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex J Clin Invest 123 9 3815 3828

    Article  CAS  Google Scholar 

  36. J Baliwag DH Barnes A Johnston 2015 Cytokines in psoriasis Cytokine 73 2 342 350

    Article  CAS  Google Scholar 

  37. KR Feingold RA Memon AH Moser C Grunfeld 1998 Paraoxonase activity in the serum and hepatic mRNA levels decrease during the acute phase response Atherosclerosis 139 307 315

    Article  CAS  Google Scholar 

  38. KR Feingold C Grunfeld 2016 Effect of inflammation on HDL structure and function Curr Opin Lipidol 27 5 521 530

    Article  CAS  Google Scholar 

  39. JE Chambers 2008 PON1 multitasks to protect health Proc Nat Acad Sci USA 105 35 12639 12640

    Article  CAS  Google Scholar 

  40. G Ferretti T Bacchetti S Masciangelo V Bicchiega 2010 HDL-paraoxonase and membrane lipid peroxidation: a comparison between healthy and obese subjects Obesity 18 6 1079 1084

    Article  CAS  Google Scholar 

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  1. Tiziana Bacchetti and Oriana Simonetti contributed equally to this work.

Authors and Affiliations

  1. Department of Life and Environmental Sciences- Biochemistry, Università Politecnica delle Marche, 60100, Ancona, Italy

    Tiziana Bacchetti

  2. Department of Clinical and Molecular Sciences- Dermatology, Università Politecnica delle Marche, 60100, Ancona, Italy

    Oriana Simonetti, Francesca Ricotti & Annamaria Offidani

  3. Department of Clinical Experimental Science and Odontostomatology- Biochemistry, Università Politecnica delle Marche, 60100, Ancona, Italy

    Gianna Ferretti

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  1. Tiziana Bacchetti
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  2. Oriana Simonetti
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  3. Francesca Ricotti
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  4. Annamaria Offidani
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  5. Gianna Ferretti
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Correspondence to Oriana Simonetti.

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Bacchetti, T., Simonetti, O., Ricotti, F. et al. Plasma oxidation status and antioxidant capacity in psoriatic children. Arch Dermatol Res 312, 33–39 (2020). https://doi.org/10.1007/s00403-019-01976-z

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  • DOI: https://doi.org/10.1007/s00403-019-01976-z

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