Skip to main content

Advertisement

SpringerLink
Log in

Polymorphisms in the promoter region of RANTES in Han Chinese and their relationship with systemic lupus erythematosus

  • Original Paper
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Abstract

Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disease afflicting more than 600,000 individuals in China. RANTES (regulated on activation, normal T cell expressed and secreted, 17q11.2-q12) is a member of the proinflammatory cytokine family known as “chemokines”. It plays an important role in the attraction and recruitment of lymphocytes, monocytes and eosinophils to sites of inflammation. A total of 146 SLE patients and 159 random healthy volunteer individuals in Han Chinese patients were enrolled in this study. Genotypes of RANTES −403 locus and −28 locus were observed to be different in all racial groups. The frequency of individuals who possessed G allele at −28 locus among SLE patients was not significantly different from that among normal controls. A total of seven compound genotypes at −403 locus and −28 locus were observed in this study. The frequency of this compound genotype (−403 G/G, −28 C/C) was different between the two groups. The distribution of genotypes and alleles at RANTES-403 locus was observed to be significantly different between renal damaged group and no renal damaged group (P<0.05), while there was no significant difference in distribution of genotypes and alleles at RANTES-28 locus between the two groups. These results suggest that (a) two genetic polymorphisms in the RANTES promoter do not correlate with SLE as individual polymorphisms. (b) interaction of the polymorphisms at two loci probably exerts a risk effect against SLE and (c) polymorphism at RANTES-403 locus is probably related with renal damage.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kotzin BL, Kozora E (2001) Anti-DNA meets NMDA in neuropsychiatric lupus. Nat Med 7(11):1175–1176

    Article  PubMed  CAS  Google Scholar 

  2. Dongqing Ye (2001) Dermatosis epidemiology. The people health publishing house, Beijing, pp 480–487

    Google Scholar 

  3. Grennan DM, Parfitt A, Manolios N, Huang Q, Hyland V, Dunckley H, Doran T, Gatenby P, Badcock C (1997) Family and twin studies in systemic lupus erythematosus. Dis Markers 13(2):93–98

    PubMed  CAS  Google Scholar 

  4. Shai R, Quismorio FP Jr, Li L et al (1999) Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families. Hum Mol Genet 8(4):639–644

    Article  PubMed  CAS  Google Scholar 

  5. Bengtsson AA, Rylander L, Hagmar L, Kwon OJ, Morrison J, Wallace DJ, Neuwelt CM, Brautbar C, Gauderman WJ, Jacob CO (2002) Risk factors for developing systemic lupus erythematosus: a case-control study in southern Sweden. Rheumatology (Oxford) (5):563–571

  6. Olson JM, Song Y, Dudek DM, Moser KL, Kelly JA, Bruner GR, Downing KJ, Berry CK, James JA, Harley JB (2002) A genome screen of systemic lupus erythematosus using affected-relative-pair linkage analysis with covariates demonstrates genetic heterogeneity. Genes Immun 3(s1):S5–S12

    Article  PubMed  CAS  Google Scholar 

  7. Lindqvist AK, Steinsson K, Johanneson B, Kristjansdottir H, Arnasson A, Grondal G, Jonasson I, Magnusson V, Sturfelt G, Truedsson L, Svenungsson E, Lundberg I, Terwilliger JD, Gyllensten UB, Alarcon-Riquelme ME (2000) A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q. J Autoimmun 14(2):169–178

    Article  PubMed  CAS  Google Scholar 

  8. Magnusson V, Lindqvist AK, Castillejo-Lopez C, Kristjansdottir H, Steinsson K, Grondal G, Sturfelt G, Truedsson L, Svenungsson E, Lundberg I, Gunnarsson I, Bolstad AI, Haga HJ, Jonsson R, Klareskog L, Alcocer-Varela J, Alarcon-Segovia D, Terwilliger JD, Gyllensten UB, Alarcon-Riquelme ME (2000) Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus. Genomics 70(3):307–314

    Article  PubMed  CAS  Google Scholar 

  9. Gaffney PM, Kearns GM, Shark KB, Ortmann WA, Selby SA, Malmgren ML, Rohlf KE, Ockenden TC, Messner RP, King RA, Rich SS, Behrens TW (1998) A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc Natl Acad Sci USA 95(25):14875–14879

    Article  PubMed  CAS  Google Scholar 

  10. Gaffney PM, Ortmann WA, Selby SA, Shark KB, Ockenden TC, Rohlf KE, Walgrave NL, Boyum WP, Malmgren ML, Miller ME, Kearns GM, Messner RP, King RA, Rich SS, Behrens TW (2000) Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analysis of 187 sib-pair families. Am J Hum Genet 66(2):547–556

    Article  PubMed  CAS  Google Scholar 

  11. Lindqvist AK, Alarcon-Riquelme ME (1999) The genetics of systemic lupus erythematosus. Scand J Immunol 50(6):562–571

    Article  PubMed  CAS  Google Scholar 

  12. Maddison P, Farewell V, Isenberg D, Aranow C, Bae SC, Barr S, Buyon J, Fortin P, Ginzler E, Gladman D, Hanly J, Manzi S, Nived O, Petri M, Ramsey-Goldman R, Sturfelt G (2002) Systemic Lupus International Collaborating Clinics. The rate and pattern of organ damage in late onset systemic lupus erythematosus. J Rheumatol 29(5):913–917

    PubMed  Google Scholar 

  13. Hashimoto H, Nishimura Y, Dong RP, Kimura A, Sasazuki T, Yamanaka K, Tokano Y, Murashima A, Kabasawa K, Hirose S (1994) HLA antigens in Japanese patients with systemic lupus erythematosus. Scand J Rheumatol 23(4):191–196

    Article  PubMed  CAS  Google Scholar 

  14. Koene HR, Kleijer M, Swaak AJ, Sullivan KE, Bijl M, Petri MA, Kallenberg CG, Roos D, von dem Borne AE, de Haas M (1998) The Fc gammaRbA-158F allele is a risk factor for systemic lupus erythematosus. Arthritis Rheum 41(10):1813–1818

    Article  PubMed  CAS  Google Scholar 

  15. Zuniga R, Ng S, Peterson MG, Reveille JD, Baethge BA, Alarcon GS, Salmon JE (2001) Low-binding alleles of Fcgamma receptor types aA and bA are inherited independently and are associated with systemic lupus erythematosus in Hispanic patients. Arthritis Rheum 44(2):361–367

    Article  PubMed  CAS  Google Scholar 

  16. Morita C, Horiuchi T, Tsukamoto H, Hatta N, Kikuchi Y, Arinobu Y, Otsuka T, Sawabe T, Harashima S, Nagasawa K, Niho Y (2001) Association of tumor necrosis factor receptor type a polymorphism 196R with systemic lupus erythematosus in the Japanese. Molecular and functional analysis. Arthritis Rheum 44(12):2819–2827

    Article  PubMed  CAS  Google Scholar 

  17. Gibson AW, Edberg JC, Wu J, Westendorp RG, Huizinga TW, Kimberly RP (2001) Novel single nucleotide polymorphisms in the distal IL-10 promotor affect IL-10 production and enhance the risk of systemic lupus erythematosus. J Immunol 166(6):15–22

    PubMed  Google Scholar 

  18. Mehrian R, Quismorio FP Jr, Strassmann G, Stimmler MM, Horwitz DA, Kitridou RC, Gauderman WJ, Morrison J, Brautbar C, Jacob CO (1998) Synergistic effect between IL-10 and bcl-2 genotypes in determining susceptibility to systemic lupus erythematosus. Arthritis Rheum 41(4):596–602

    Article  PubMed  CAS  Google Scholar 

  19. Horiuchi T, Nishizaka H, Yasunaga S, Higuchi M, Tsukamoto H, Hayashi K, Nagasawa K (1999) Association of Fas/APO-1 gene polymorphism with systemic lupus erythematosus in Japanese. Rheumatology 38(6):516–520

    Article  PubMed  CAS  Google Scholar 

  20. Baggiolini M (1998) Chemokines and leukocyte traffic. Nature 392(6676):565–568

    Article  PubMed  CAS  Google Scholar 

  21. Hsieh SC, Yu HS, Lin WW, Sun KH, Tsai CY, Huang DF, Tsai YY, Yu CL (2003) Anti-SSB/La is one of the antineutrophil autoantibodies responsible for neutropenia and functional impairment of polymorphonuclear neutrophils in patients with systemic lupus erythematosus. Clin Exp Immunol 131(3):506–516

    Article  PubMed  CAS  Google Scholar 

  22. Kim HL, Lee DS, Yang SH (2002) The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE. Am J Kidney Dis 40(6):1146–1152

    Article  PubMed  CAS  Google Scholar 

  23. Chen S, Liu Z, Chen H, Zhou H, Wang J, Li L (2002) Glomerular chemokine expression and the effect of steroid and cyclophosphamide pulse therapy in human crescentic glomerulonephritis. Chin Med J (Engl) 115(9):1301–1307

    CAS  Google Scholar 

  24. Mancardi S, Vecile E, Dusetti N, Calvo E, Stanta G, Burrone OR, Dobrina A (2003) Evidence of CXC, CC and C chemokine production by lymphatic endothelial cells. Immunology 108(4):523–523

    Article  PubMed  CAS  Google Scholar 

  25. Aoki M, Pawankar R, Niimi Y, Kawana S (2003) Mast cells in basal cell carcinoma express VEGF, IL-8 and RANTES. Int Arch Allergy Immunol 130(3):216–223

    Article  PubMed  CAS  Google Scholar 

  26. Dorner BG, Steinbach S, Huser MB, Kroczek RA, Scheffold A (2003) Single-cell analysis of the murine chemokines MIP-1alpha, MIP-1beta, RANTES and ATAC/lymphotactin by flow cytometry. J Immunol Methods 274(1–2):83–91

    Article  PubMed  CAS  Google Scholar 

  27. Nelson PJ, Kim HT, Manning WC, Goralski TJ, Krensky AM (1993) Genomic organization and transcriptional regulation of the RANTES chemokine gene. J Immunol 151(5):2601–2612

    PubMed  CAS  Google Scholar 

  28. Liu H, Chao D, Nakayama EE, Taguchi H, Goto M, Xin X, Takamatsu JK, Saito H, Ishikawa Y, Akaza T, Juji T, Takebe Y, Ohishi T, Fukutake K, Maruyama Y, Yashiki S, Sonoda S, Nakamura T, Nagai Y, Iwamoto A, Shioda T (1999) Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression. Proc Natl Acad Sci USA 96(8):4581–4585

    Article  PubMed  CAS  Google Scholar 

  29. Alam R (1997) Chemokines in allergic inflammation. J Allergy Clin Immunol 99(3):273–277

    Article  PubMed  CAS  Google Scholar 

  30. Tsukahara T, Makino Y, Fujii T, Ogawa M, Saisho H, Hamano Y, Ueda S, Akikusa B, Danoff TM (2002) Role of RANTES in the development of autoimmune tissue injuries in MRL-Fas lpr mice. Clin Immunol 103(1):89–97

    Article  PubMed  CAS  Google Scholar 

  31. Kameyoshi Y, Dorschner A, Mallet AI, Christophers E, Schroder JM (1992) Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 176(2):587–592

    Article  PubMed  CAS  Google Scholar 

  32. Roscic-Mrkic B, Fischer M, Leemann C, Manrique A, Gordon CJ, Moore JP, Proudfoot AE, Trkola A (2003) RANTES (CCL5) utilizes the proteoglycan CD44 as an auxiliary receptor to mediate cellular activation signals and HIV-1 enhancement. Blood 102(4):1169–1177

    Article  PubMed  CAS  Google Scholar 

  33. Stellato C, Collins P, Ponath PD, Soler D, Newman W, La Rosa G, Li H, White J, Schwiebert LM, Bickel C, Liu M, Bochner BS, Williams T, Schleimer RP (1997) Production of the Novel C-C Chemokine MCP-4 by Airway Cells and Comparison of Its Biological Activity to Other C-C Chemokines. J Clin Invest 99(5):926–936

    PubMed  CAS  Google Scholar 

  34. Wang JH, Trigg CJ, Devalia JL, Jordan S, Davies RJ (1994) Effect of inhaled beclomethasone dipropionate on expression of proinflammatory cytokines and activated eosinophils in the bronchial epithelium of patients with mild asthma. J Allergy Clin Immunol 94(6 Pt 1):1025–1034

    Article  PubMed  CAS  Google Scholar 

  35. Wang JH, Devalia JL, Xia C, Sapsford RJ, Davies RJ (1996) Expression of RANTES by human bronchial epithelial cells in vitro and in vivo and the effect of corticosteroids. Am J Respir Cell Mol Biol 14(1):27–35

    PubMed  Google Scholar 

  36. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40(9):1725

    Article  PubMed  CAS  Google Scholar 

  37. Szalai C, Duba J, Prohaszka Z, Kalina A, Szabo T, Nagy B, Horvath L, Csaszar A (2001) Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 −2518 G/G genotype in CAD patients. Atherosclerosis 158(1):233–239

    Article  PubMed  CAS  Google Scholar 

  38. al Sharif F, Ollier WE, Hajeer AH (1999) A rare polymorphism at position −28 in the human RANTES promoter. Eur J Immunogenet 26(5):373–374

    Article  PubMed  CAS  Google Scholar 

  39. McDermott DH, Beecroft MJ, Kleeberger CA, Al-Sharif FM, Ollier WE, Zimmerman PA, Boatin BA, Leitman SF, Detels R, Hajeer AH, Murphy PM (2000) Chemokine RANTES promoter polymorphism affects risk of both HIV infection and disease progression in the Multicenter AIDS Cohort Study. AIDS 14(14):2671–2678

    Article  PubMed  CAS  Google Scholar 

  40. Noris M, Bernasconi S, Casiraghi F, Sozzani S, Gotti E, Remuzzi G, Mantovani A (1995) Monocyte chemoattractant protein-1 is excreted in excessive amounts in the urine of patients with lupus nephritis. Lab Invest 73(6):804–809

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements

We thank the patients for their cooperation in donating blood samples. This work was funded by grants from the National Natural Science Foundation of China (30371247), the Natural Science Foundation of Anhui Province (98437231) and the Key Program of Anhui Province Education Department (2002 kj175ZD).

Author information

Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, Anhui, China

    Dong Qing Ye, Shi Gui Yang, Yi Song Hu, Jing Yin, Guo Qing Zhang, Hui Hui Liu, Qian Wang & Ke Chun Zhang

  2. Department of Rheumatism, Anhui Provincial Hospital, Hefei, Anhui, China

    Xiang Pei Li

  3. Division of Adult and Community Health, National Center for Disease Control and Prevention, Atlanta, GA, USA

    Ma Xia Dong

  4. Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

    Xue Jun Zhang

Authors
  1. Dong Qing Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shi Gui Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiang Pei Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yi Song Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jing Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Guo Qing Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hui Hui Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Qian Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ke Chun Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Ma Xia Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Xue Jun Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dong Qing Ye.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ye, D.Q., Yang, S.G., Li, X.P. et al. Polymorphisms in the promoter region of RANTES in Han Chinese and their relationship with systemic lupus erythematosus. Arch Dermatol Res 297, 108–113 (2005). https://doi.org/10.1007/s00403-005-0581-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00403-005-0581-9

Keywords

Search

Navigation