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Calcium phosphate mineralization with linear poly(ethylene imine): a time-resolved study

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Abstract

We have earlier shown that linear poly(ethylene imine) (LPEI) is an efficient growth modifier for calcium phosphate mineralization from aqueous solution (Shkilnyy et al., Langmuir, 2008, 24 (5), 2102). The current study addresses the growth process and the reason why LPEI is such an effective additive. To that end, the solution pH and the calcium and phosphate concentrations were monitored vs. reaction time using potentiometric, complexometric, and photometric methods. The phase transformations in the precipitates and particle morphogenesis were analyzed by X-ray diffraction and transmission electron microscopy, respectively. All measurements reveal steep decreases of the pH, calcium, and phosphate concentrations along with a rapid precipitation of brushite nanoparticles early on in the reaction. Brushite transforms into hydroxyapatite (HAP) within the first 2 h, which is much faster than what is reported, for example, for calcium phosphate precipitated with poly(acrylic acid). We propose that poly(ethylene imine) acts as a proton acceptor (weak buffer), which accelerates the transformation from brushite to HAP by taking up the protons that are released from the calcium phosphate precipitate during the phase transformation.

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Acknowledgment

We thank I. Zenke for the help with XRD, R. Pitschke, H. Runge, and Dr. L. Kind for their help with electron microscopy, and Dr. H. Schlaad for useful discussion. A.S. acknowledges the MPI of Colloids and Interfaces for a postdoctoral fellowship. We thank the MPI of Colloids and Interfaces (Colloid Chemistry Department), the Fonds der Chemischen Industrie, and the University of Potsdam for financial support.

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Author notes

  1. Andriy Shkilnyy

    Present address: Department of Chemical and Biotechnological Engineering, Université de Sherbrooke, 2500, Blvd. de l’Université, Sherbrooke, QC, Canada

Authors and Affiliations

  1. Institute of Chemistry, University of Potsdam, 14476, Golm, Germany

    Andriy Shkilnyy, Stefanie Schöne, Claudia Rumplasch, Annett Uhlmann, Annett Hedderich & Andreas Taubert

  2. Max-Planck-Institute of Colloids and Interfaces, 14476, Golm, Germany

    Andriy Shkilnyy & Andreas Taubert

  3. Institute of Earth and Environmental Sciences, University of Potsdam, 14476, Golm, Germany

    Christina Günter

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  1. Andriy Shkilnyy
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  2. Stefanie Schöne
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  7. Andreas Taubert
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Correspondence to Andreas Taubert.

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Shkilnyy, A., Schöne, S., Rumplasch, C. et al. Calcium phosphate mineralization with linear poly(ethylene imine): a time-resolved study. Colloid Polym Sci 289, 881–888 (2011). https://doi.org/10.1007/s00396-011-2403-2

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  • DOI: https://doi.org/10.1007/s00396-011-2403-2

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