Abstract
Purpose
Increasing secretion and production of glucagon-like peptide-1 (GLP-1) by continuous ingestion of certain food components has been expected to prevent glucose intolerance and obesity. In this study, we examined whether a physiological dose (5% weight in diet) of digestion-resistant maltodextrin (RMD) has a GLP-1-promoting effect in rats fed a high-fat and high-sucrose (HFS) diet.
Methods
Rats were fed a control diet or the HFS (30% fat, 40% sucrose wt/wt) diet supplemented with 5% RMD or fructooligosaccharides (FOS) for 8 weeks or for 8 days in separated experiments. Glucose tolerance, energy intake, plasma and tissue GLP-1 concentrations, and cecal short-chain fatty acids concentrations were assessed.
Results
After 4 weeks of feeding, HFS-fed rats had significantly higher glycemic response to oral glucose than control rats, but rats fed HFS + RMD/FOS did not (approx. 50% reduction vs HFS rats). HFS + RMD/FOS-fed rats had higher GLP-1 responses (~twofold) to oral glucose, than control rats. After 8 weeks, visceral adipose tissue weight was significantly higher in HFS-fed rats than control rats, while HFS + RMD/FOS rats had a trend of reduced gain (~50%) of the tissue weight. GLP-1 contents and luminal propionate concentrations in the large intestine increased (>twofold) by adding RMD/FOS to HFS. Eight days feeding of RMD/FOS-supplemented diets reduced energy intake (~10%) and enhanced cecal GLP-1 production (~twofold), compared to HFS diet.
Conclusions
The physiological dose of a prebiotic fiber promptly (within 8 days) promotes GLP-1 production in rats fed an obesogenic diet, which would help to prevent excess energy intake and fat accumulation.
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Abbreviations
- HFS:
-
High-fat and high-sucrose
- GLP-1:
-
Glucagon-like peptide-1
- RMD:
-
Resistant maltodextrin
- FOS:
-
Fructooligosaccharides
- GIP:
-
Glucose-dependent insulinotropic polypeptide
- OGTT:
-
Oral glucose tolerance test
- PYY:
-
Peptide YY
- DPP-IV:
-
Dipeptidyl peptidase-IV
- SCFA:
-
Short-chain fatty acid
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The research was supported by JSPS KAKENHI Grant No. 26252016.
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Y. Kishimoto and S. Kanahori are employees of Matsutani Chemical Industry. T. Hira, R. Suto, and H. Hara, no conflicts of interest.
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Hira, T., Suto, R., Kishimoto, Y. et al. Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity. Eur J Nutr 57, 965–979 (2018). https://doi.org/10.1007/s00394-017-1381-7
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DOI: https://doi.org/10.1007/s00394-017-1381-7