Abstract
Objective
This study was carried out to determine whether changes in hemorheological parameters parallel the severity of essential hypertension.
Methods
A total of 198 older hypertensive patients were recruited and classified into 3 stages of hypertension according to the grading standard of hypertension. The whole blood viscosity (WBV) at various shear rates, plasma viscosity and erythrocyte rheology (including erythrocyte rigidity index, erythrocyte aggregation index and erythrocyte deformation index) were examined.
Results
Erythrocyte rheology paralleled the severity of essential hypertension and was significantly correlated to the average 24 h systolic blood pressure and diastolic blood pressure. Logistic analysis revealed that erythrocyte rigidity and the erythrocyte aggregation index were positively correlated with the severity of hypertension, while the erythrocyte deformation index was negatively correlated. No association was found between WBV, plasma viscosity and the severity of hypertension.
Conclusion
The rheological properties of erythrocyte viscosity were correlated with the severity of hypertension in older people but the WBV and plasma viscosity were not.
Zusammenfassung
Zielsetzung
In der vorliegenden Studie wurde untersucht, ob sich hämorheologische Störungen parallel zum Schweregrad einer essenziellen Hypertonie verändern.
Methoden
Insgesamt wurden 198 ältere Patienten mit Bluthochdruck in die Studie eingeschlossen und entsprechend der Standardeinteilung einem von 3 Hypertoniestadien zugeordnet. Untersucht wurden die Viskosität des Vollbluts bei verschiedenen Schergeschwindigkeiten, die Plasmaviskosität und die rheologischen Eigenschaften der Erythrozyten, einschließlich des Rigiditäts-, Aggregations- und Verformungsindex der Erythrozyten.
Ergebnisse
Die rheologischen Eigenschaften der Erythrozyten waren mit dem Schweregrad der essenziellen Hypertonie assoziiert und korrelierten signifikant mit dem durchschnittlichen systolischen und diastolischen Blutdruck über 24 h. Logistische Analysen ergaben, dass die Indizes der Erythrozytenrigidität und -aggregation positiv mit der Hypertonieschwere korrelierten, der Erythrozytenverformungsindex dagegen negativ. Kein Zusammenhang fand sich bezüglich der Viskosität des Vollbluts und Plasmas.
Schlussfolgerung
Die rheologischen Eigenschaften der Erythrozytenviskosität korrelierten mit dem Schweregrad der Hypertonie bei älteren Menschen, während für die Viskosität des Vollbluts und Plasmas kein solcher Zusammenhang bestand.
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Acknowledgement
This study was supported by the National Natural Science Fund (No: 81401158).
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G-x. Fu, M. Ji, L‑z. Han, C‑c. Xu, F‑f. Pan, T-j. Hu and Y. Zhong state that there are no conflicts of interest.
All patients enrolled in this study were fully informed about the purpose and procedures and gave written informed consent. The protocol of the study was approved by the ethics committee of the institutions involved.
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Fu, Gx., Ji, M., Han, Lz. et al. Erythrocyte rheological properties but not whole blood and plasma viscosity are associated with severity of hypertension in older people. Z Gerontol Geriat 50, 233–238 (2017). https://doi.org/10.1007/s00391-016-1039-8
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DOI: https://doi.org/10.1007/s00391-016-1039-8