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Left congenital diaphragmatic hernia-associated musculoskeletal deformities

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Abstract

Aim

With the advancement in the treatment strategies of congenital diaphragmatic hernia (CDH), there is an increase in the survival rates. This fact leads to an increase in the morbidity and extrapulmonary complications in the long term such as failure to thrive, hernia recurrence, neurodevelopmental delay, gastrointestinal problems, and musculoskeletal anomalies. Herein, we aim to investigate the association between the long-term musculoskeletal complications in CDH patients regarding the defect size, repair type, and perinatal parameters.

Methods

After Institutional Review Board approval was obtained (2017-6361), a retrospective chart review was performed on CDH patients from 2003 to 2016. Patients who were operated due to left-sided isolated congenital diaphragmatic hernia and survived to date were included in the study. Data were collected on demographics, preoperative characteristics, operative interventions, and postoperative outcomes. Statistical analysis was performed with IBM SPSS Statistics 20.0.0 (Chicago, IL).

Results

There were 98 patients with left CDH of whom 33 (33.7%) had primary repair, 25 (25.5%) had patch repair, and 40 (40.8%) had muscle flap repair. The median age of the patients was 6.00 ± 3.83 years. 45 patients (45.9%) had large diaphragmatic defects, 28 patients (28.6%) had at least one type of musculoskeletal deformities, 2 of which were pectus carinatum, 16 were pectus excavatum, and 18 were scoliosis. CDH patients who had small diaphragmatic defects and repaired with a patch were less likely develop musculoskeletal deformities while who had primary abdominal closure after ventral hernia significantly have more pectus excavatum.

Conclusion

Although there was a trend towards an increased risk of the pectus deformity and scoliosis in patients repaired with muscle flap, it did not reach statistical significance. There is a correlation between musculoskeletal deformities and the severity of the CDH.

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Acknowledgements

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Division of Pediatric General and Thoracic Surgery, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, MLC 11025, Cincinnati, OH, 45229-3039, USA

    Emrah Aydın, Patricia Burns, Foong-Yen Lim & Jose Luis Peiró

  2. Department of Pediatric Surgery, Koç University School of Medicine, Istanbul, Turkey

    Emrah Aydın & Oğuz Özler

Authors
  1. Emrah Aydın
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  2. Oğuz Özler
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  3. Patricia Burns
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  4. Foong-Yen Lim
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  5. Jose Luis Peiró
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Contributions

All authors have made substantial contributions to the conception and design of the study, acquisition, analysis, and interpretation of data, drafting the article and revising it for important intellectual content and final approval of the version to be submitted.

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Correspondence to Emrah Aydın.

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The authors report no proprietary or commercial interest in any product mentioned or concept discussed in this article.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (IRB #2017-6361) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Aydın, E., Özler, O., Burns, P. et al. Left congenital diaphragmatic hernia-associated musculoskeletal deformities. Pediatr Surg Int 35, 1265–1270 (2019). https://doi.org/10.1007/s00383-019-04548-4

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  • DOI: https://doi.org/10.1007/s00383-019-04548-4

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