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Initial clinical experience with oral manganese (CMC-001) for liver MR imaging

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Abstract

Recently, a new oral liver-specific manganese-based MR agent (CMC-001) has been introduced. This contrast medium is delivered to the liver in high concentrations in the portal vein and very low doses in the hepatic artery, as only small amounts of manganese enter the general circulation. It is taken up by the hepatocytes and excreted in the bile. Our initial experience with the new MR contrast medium in a variety of patients is reported. A total of 20 patients (11 males and 9 females) were studied with MR imaging 2 h after oral ingestion of the contrast agent. Sixteen patients were referred for evaluation of focal liver lesion(s), whereas in the remaining four patients, evaluation of the biliary tract was requested. In the 17 patients without biliary obstruction, there was an increased signal intensity of the liver parenchyma, whereas in the three patients with biliary obstruction, the uptake was delayed. There was excellent visualization of the biliary system on the T1-weighted images in the 16 patients without biliary obstruction referred for evaluation of a focal liver lesion. In seven patients, the uptake was patchy. In patients with focal liver lesions or biliary tract diseases, it is possible to increase the signal intensity of the liver parenchyma after the oral intake of CMC-001. In patients without biliary tract obstruction, the biliary system is easily visualized. Oral manganese seems to be useful in hepatobiliary MRI. Further research is strongly warranted.

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References

  1. Bellin M-F (2006) Safety of MR liver specific agents. In: Thomsen HS (ed) Safety issues and ESUR guidelines. Heidelberg, Springer Verlag pp 121–128

    Google Scholar 

  2. Bartolozzi C, Donati F, Cioni D, Crocetti L, Lencioni R (2000) MnDPDP-enhanced MRI vs. dual phase spiral CT in the detection of hepatocellular carcinoma in cirrhosis. Eur Radiol 10:1697–1702

    Article  PubMed  CAS  Google Scholar 

  3. Thomsen HS, Loegager V, Noergaard H, Chabanova E, Moller JM, Sonne J (2004) Oral manganese for liver imaging at three different field strengths. Acad Radiol 2004 11:630–636

    Article  PubMed  Google Scholar 

  4. Chabanova E, Thomsen HS, Loegager V et al (2004) Effect of new manganese contrast agent on tissue intensities: comparison of 0.23 T, 0.6T and 1.5 T MRI. A part of a phase I trial. MAGMA 17:28–35

    Article  PubMed  CAS  Google Scholar 

  5. Semelka RC, Helmberger TKG (2001) Contrast agents for MR imaging of the liver. Radiology 218:27–38

    PubMed  CAS  Google Scholar 

  6. Thomsen HS, Svendsen O, Klastrup S (2004) Increased manganese concentration in the liver after oral intake. Acad Radiol 11:38–44

    Article  PubMed  Google Scholar 

  7. Mena I (1981) Manganese. In: Bronner F, Coburn JW (eds.) Disorders on mineral metabolism. Academic Press, New York pp 233–270

    Google Scholar 

  8. Underwood EJ (1971). Manganese. In: Underwood EJ (ed). Trace elements in human and animal nutrition. Academic Press, New York pp 177–207

    Google Scholar 

  9. Keen CL, Lönnerdal B, Hurley LS (1984) Manganese. In: Frieden J (ed) Biochemistry of the essential ultra-trace elements. Plenum Press, New York pp 89–132

    Google Scholar 

  10. Korc M (1988) Manganese homeostasis in humans and its role in disease states. In: Korc M (ed) Essential and toxic trace elements in human health and disease. Alan R. Liss, New York pp 253–273

    Google Scholar 

  11. Marti-Bonmati L, Fog AF, Op de Beeck B et al (2003) Safety and efficacy of mangafodipir trisodium in patients with liver lesions and cirrhosis. Eur Radiol 13:1685–1692

    Article  PubMed  Google Scholar 

  12. Fore H, Morton RA (1952) Manganese in rabbit tissue. Biochem J 51:600

    PubMed  CAS  Google Scholar 

  13. Tipton IH, Cook MJ (1963) Trace elements in human tissue. II. Adult subjects from the United States. Health Phys 9:103

    Article  Google Scholar 

  14. Sahani DV, Kalva SP, Fischman AJ et al (2005) Detection of metastases from andenocarcinoma of the colon and pancreas: Comparison of mangadipir trisodium-enhanced liver MRI and whole-body FDG PET. Am J Roentgenol 185:239–246

    Google Scholar 

  15. Fayad LM, Kamel IR, Mitchell DG, Bluemke DA (2005) Functional MR cholangiography: Diagnosis of functional abnormalities of the gall bladder and biliary tree. Am J Roentgenol 184:1563–1571

    Google Scholar 

  16. Hottat N, Winant C, Metens T, Bourgeois N, Devière J, Matos C (2005) MR cholangiography with manganese dipyridoxyl diphosphate in the evaluation of biliary-enteric anastomoses : Preliminary experience. Am J Roentgenol 184:1556–1562

    Google Scholar 

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Acknowledgement

The authors are thankful to Copenhagen-Malmö-Contrast (CMC) for providing the contrast agent CMC-001.

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Authors and Affiliations

  1. Department of Diagnostic Radiology 54E2, Copenhagen University Hospital at Herlev, Herlev Ringvej 75, DK-2730, Herlev, Denmark

    Henrik S. Thomsen, Elizaveta Chabanova, Jakob M. Moller, Per Leth-Espensen & Vibeke Logager

  2. Department of Surgical Gastroenterology, Copenhagen University Hospital at Herlev, DK-2730, Herlev, Denmark

    Flemming Burcharth & Flemming Moesgaard

  3. Department of Radiology, University Medical Center Nijmegen, P.O. Box 9101, NL-6500, HB Nijmegen, The Netherlands

    Jelle O. Barentsz, Helena M. Dekker & Satoru Takahashi

Authors
  1. Henrik S. Thomsen
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  2. Jelle O. Barentsz
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  3. Flemming Burcharth
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  4. Elizaveta Chabanova
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  5. Helena M. Dekker
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  6. Flemming Moesgaard
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  7. Jakob M. Moller
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  8. Per Leth-Espensen
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  9. Vibeke Logager
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  10. Satoru Takahashi
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Corresponding author

Correspondence to Henrik S. Thomsen.

Additional information

Financial disclosure: Thomsen HS. Manganese-containing magnetic resonance contrast agent. US patent no. 6,015,545/ 18 January 2000.

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Thomsen, H.S., Barentsz, J.O., Burcharth, F. et al. Initial clinical experience with oral manganese (CMC-001) for liver MR imaging. Eur Radiol 17, 273–278 (2007). https://doi.org/10.1007/s00330-006-0336-9

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  • DOI: https://doi.org/10.1007/s00330-006-0336-9

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