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The number of segregating sites in a sample of DNA sequences from a geographically structured population

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Abstract.

 The distribution of the number of segregating sites among randomly sampled DNA sequences from a geographically structured population is studied. We assume the infinitely-many-sites model of neutral genes and no recombination. Employing the genealogical process, we derive an equation for the generating function of the distribution of the number of segregating sites. First we study the strong-migration limit and prove that the distribution converges to that for a panmictic population. We also study the case of two sampled DNA sequences in the d-dimensional torus model with homogeneous migration.

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Authors and Affiliations

  1. Department of Biology, Faculty of Science, Kyushu University, 33, Fukuoka 812, Japan, , , , , , JP

    Morihiro Notohara

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  1. Morihiro Notohara
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Received 13 July 1995; received in revised form 21 April 1997

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Notohara, M. The number of segregating sites in a sample of DNA sequences from a geographically structured population. J Math Biol 36, 188–200 (1997). https://doi.org/10.1007/s002850050097

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  • DOI: https://doi.org/10.1007/s002850050097

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