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TRP functions in the broncho-pulmonary system

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Abstract

The current understanding of the role of transient receptor potential (TRP) channels in the airways and lung was initially based on the localization of a series of such channels in a subset of sensory nerve fibers of the respiratory tract. Soon after, TRP channel expression and function have been identified in respiratory nonneuronal cells. In these two locations, TRPs regulate physiological processes aimed at integrating different stimuli to maintain homeostasis and to react to harmful agents and tissue injury by building up inflammatory responses and repair processes. There is no doubt that TRPs localized in the sensory network contribute to airway neurogenic inflammation, and emerging evidence underlines the role of nonneuronal TRPs in orchestrating inflammation and repair in the respiratory tract. However, recent basic and clinical studies have offered clues regarding the contribution of neuronal and nonneuronal TRPs in the mechanism of asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cough, and other respiratory diseases.

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Acknowledgments

This paper was supported by a Tuscany Region Grant (Nutraceutica, POFCADT_2015).

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Authors and Affiliations

  1. Clinical Pharmacology Unit, Department of Health Sciences, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy

    Francesco De Logu, Riccardo Patacchini & Pierangelo Geppetti

  2. Chiesi Farmaceutici S.p.A, Parma, Italy

    Riccardo Patacchini

  3. Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Giovanni Fontana

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  1. Francesco De Logu
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  2. Riccardo Patacchini
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  3. Giovanni Fontana
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  4. Pierangelo Geppetti
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Correspondence to Pierangelo Geppetti.

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This article is a contribution to the special issue on the Role of TRP Ion Channels in Physiology and Pathology - Guest Editor: Armen Akopian

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De Logu, F., Patacchini, R., Fontana, G. et al. TRP functions in the broncho-pulmonary system. Semin Immunopathol 38, 321–329 (2016). https://doi.org/10.1007/s00281-016-0557-1

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