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Intravoxel incoherent motion imaging for assessment of bone marrow infiltration of monoclonal plasma cell diseases

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Abstract

Modern imaging techniques have demonstrated that monoclonal plasma cell diseases infiltrate the bone marrow in a diffuse, focal, mixed pattern. While focal lesions can be easily counted and measured, the diffuse lesions of the infiltration are hard to assess. We therefore investigated 31 patients with monoclonal plasma cell diseases of all stages with intravoxel incoherent motion imaging of the same region of the pelvis from where afterwards a biopsy was obtained. We found a significant correlation between plasma cell percentage in bone marrow histology and the imaging parameters “apparent diffusion coefficient” and the diffusion coefficient D. Furthermore, those parameters correlated with other factors of disease activity, e.g., monoclonal protein, hemoglobin, and immunoparesis. In summary, we found that the non-invasively acquired imaging parameters correlated with the degree of plasma cell infiltration in the bone marrow.

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Acknowledgments

Parts of this study have been supported by a grant from the German Research Foundation (Transregio 79) and a grant from the International Myeloma Foundation.

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Authors and Affiliations

  1. German Cancer Research Center, Heidelberg, Germany

    Rajiv Shah, Bram Stieltjes, Migle Sumkauskaite, Stefan Delorme & Heinz-Peter Schlemmer

  2. Institute of Pathology, University of Heidelberg, Heidelberg, Germany

    Mindaugas Andrulis

  3. National Cancer Institute, NIH, Bethesda, USA

    Ruth Pfeiffer & Ola Landgren

  4. Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany

    Hartmut Goldschmidt & Jens Hillengass

  5. Department of thoracic oncology, Thoraxklinik, University Hospital Heidelberg, Amalienstr. 5, 69126, Heidelberg, Germany

    Rajiv Shah

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  1. Rajiv Shah
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  2. Bram Stieltjes
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Correspondence to Rajiv Shah.

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Shah, R., Stieltjes, B., Andrulis, M. et al. Intravoxel incoherent motion imaging for assessment of bone marrow infiltration of monoclonal plasma cell diseases. Ann Hematol 92, 1553–1557 (2013). https://doi.org/10.1007/s00277-013-1786-1

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  • DOI: https://doi.org/10.1007/s00277-013-1786-1

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