Abstract
Background
This study aimed to determine the efficacy and safety of a new facial rejuvenation procedure that combines a fractional carbon dioxide (CO2) laser, an ultrasound emitter, and a cosmeceutical preparation to be applied intraoperatively.
Methods
A split-face, double-blind randomized prospective study of 14 patients was designed, in which one half of the face was treated with a fractional CO2 laser, with the other half receiving the same laser and acoustic pressure ultrasound for transepidermal delivery of cosmeceuticals. Two semiquantitative scales and two visual analog scales were completed to evaluate the efficacy of each treatment. The results were assessed on the basis of photographs taken before treatment and then after 1, 2, and 6 months afterward. Potential adverse effects and complications were recorded.
Results
Both treatments achieved significant improvements in all parameters evaluated (p < 0.001). The combined ultrasound and cosmeceutical treatment had better scores for reduced fine lines and wrinkles as well as for overall facial aging at 6 months (p < 0.01), with nearly 80 % overall improvement in facial aging. The treatment was well tolerated, and no unexpected adverse effects were observed. The majority of the patients (86 %) stated that they were satisfied or very satisfied with their results.
Conclusion
One session of fractional ablative CO2 laser and acoustic pressure ultrasound technology for transepidermal delivery of cosmeceuticals is an effective method for treating facial rejuvenation.
Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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References
Alexiades-Armenaka MR, Dover JS, Arndt KA (2008) The spectrum of laser skin resurfacing: nonablative, fractional, and ablative laser resurfacing. J Am Acad Dermatol 58:719–737
Lupo M, Jacob L (2011) Cosmeceuticals used in conjunction with laser resurfacing. Semin Cutan Med Surg 30:156–162
Nusgens BV, Humbert P, Rougier A, Richard A, Lapière CM (2002) Stimulation of collagen biosynthesis by topically applied vitamin C. Eur J Dermatol 4:32–34
Humbert PG, Haftek M, Creidi P et al (2003) Topical ascorbic acid on photoaged skin: clinical, topographical, and ultrastructural evaluation: double-blind study vs placebo. Exp Dermatol 12:237–244
Pitt WG, Husseini GA, Staples BJ (2004) Ultrasonic drug delivery: a general review. Expert Opin Drug Deliv 1:37–56
Cassuto DA, Sadik NS, Scrimali L, Sirago P (2008) An innovative device for fractional CO2 laser resurfacing: a preliminary clinical study. Am J Cosmet Surg 25:97–101
Chan NP, Ho SG, Yeung CK, Shek SY, Chan HH (2010) Fractional ablative carbon dioxide laser resurfacing for skin rejuvenation and acne scars in Asians. Lasers Surg Med 42:615–623
Alexiades-Armenaka M, Sarnoff D, Gotkin R, Sadick N (2011) Multicenter clinical study and review of fractional ablative CO2 laser resurfacing for the treatment of rhytides, photoaging, scars, and striae. J Drugs Dermatol 104:352–362
Trelles MA, Shohat M, Urdiales F (2011) Safe and effective one-session fractional skin resurfacing using a carbon dioxide laser device in super-pulse mode: a clinical and histologic study. Aesthet Plast Surg 35:31–42
Tierney EP, Hanke CW (2011) Fractionated carbon dioxide laser treatment of photoaging: prospective study and review of the literature. Dermatol Surg 37:1279–1290
Stebbins WG, Hanke CW (2011) Ablative fractional resurfacing for photoaging of the hands: pilot study of 10 patients. Dermatol Ther 24:62–70
Tajirian AL, Goldberg DJ (2011) Fractional ablative laser skin resurfacing: a review. J Cosmet Laser Ther 13:262–264
Sasaki GH, Travis HM, Tucker B (2009) Fractional CO2 laser resurfacing of photoaged facial and nonfacial skin: histologic and clinical results and side effects. J Cosmet Laser Ther 11:190–201
Trelles MA, Garcia RJ, Mellor K (1998) Coherent versus sharplan dans le resurfacing cutane: modifications du collagene et de l’ elastine. J Med Esthet Chir Dermatol 97:15–20
Trelles MA (2003) Laser ablative resurfacing for photorejuvenation based on more than a decade’s experience and 1,200 patients: personal observations. J Cosmet Dermatol 2:2–13
Trelles MA, Rigau J, Mellor TK, Garcia L (1998) A clinical and histological comparison of flash scanning versus pulsed technology in carbon dioxide laser facial skin resurfacing. Dermatol Surg 24:43–49
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Trelles, M.A., Leclère, F.M. & Martínez-Carpio, P.A. Fractional Carbon Dioxide Laser and Acoustic-Pressure Ultrasound for Transepidermal Delivery of Cosmeceuticals: A Novel Method of Facial Rejuvenation. Aesth Plast Surg 37, 965–972 (2013). https://doi.org/10.1007/s00266-013-0176-3
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DOI: https://doi.org/10.1007/s00266-013-0176-3