Abstract
The use of paired tracers such as 124I/131I and 86Y/90Y allows pretherapy PET imaging with positron emitting radioisotopes of the same element as used for therapy. Whereas nowadays most therapy nuclides are produced by reactors or generators, the production of the corresponding PET isotopes requires the irradiation of adequate targets using particle accelerators such as cyclotrons. This paper describes the production routes for 124I and 86Y.
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References
Ott RJ. Imaging technologies for radionuclide dosimetry. Phys Med Biol. 1996;41:1885–94.
Blasberg RG, Roelcke U, Weinreich R, von Ammon K, Crompton N, Günther I, et al. [124I]Iododeoxyuridine imaging tumor proliferation. J Nucl Med. 1996;37 Suppl:P59.
Wilson CB, Snook DE, Dhokia B, Taylor CV, Watson IA, Lammertsma AA, et al. Quantitative measurement of monoclonal antibody distribution and blood flow using positron emission tomography and 124iodine in patients with breast cancer. Int J Cancer. 1991;47:344–7.
Langen KJ, Coenen HH, Roosen N, Kling P, Muzik O, Herzog H, et al. SPECT studies of brain tumors with L-3-[123I] iodo-alpha-methyl tyrosine: comparison with PET, 124IMT and first clinical results. J Nucl Med. 1990;31:281–6.
Frey P, Townsend D, Falattet A, De Gautard R, Widgren S, Jeavons A, et al. Tomographic imaging of the human thyroid using 124I. J Clin Endocrinol Metab. 1986;63:918–27.
Stepanek J, Larsson B, Weinreich R. Auger-electron spectra of radionuclides for therapy and diagnostics. Acta Oncol. 1996;35:863–8.
Freudenberg L, Jentzen W, Görges R, Petrich T, Marlowe RJ, Knust J, et al. 124I-PET-dosimetry in advanced differentiated thyroid cancer: therapeutic impact. Nuklearmedizin. 2007;46:121–8.
Ott RJ, Tait D, Flower MA, Babich JW, Lambrecht RM. Treatment panning for I-131-mIBG radiotherapy of neural crest tumours using I-124-mIBG positron emission tomography. Br J Radiol. 1992;65:787–91.
Kondo K, Lambrecht RM, Norton EF, Wolf AP. Cyclotron isotopes and radiopharmaceuticals--XXII. Improved targetry and radiochemistry for production of 123I and 124I. Int J Appl Radiat Isot. 1977;28:765–71.
Akbari RB, Ott RJ, Trott NG, Sharma HL, Smith AG. Radionuclide purity and radiation dosimetry of 124I used in positron tomography of the thyroid. Phys Med Biol. 1986;31:789–91.
Lambrecht RM, Sajjad M, Qureshi MA, Al-Yanbawi SJ. Production of iodine-124. J Radioanal Nucl Chem Lett. 1988;127:143–50.
International Atomic Energy Agency. Charged particle cross-section database for medical radioisotope production: diagnostic radioisotopes and monitor reactions, IAEA-TECDOC-1211, 2001; IAEA, Vienna
Scholten B, Kovács Z, Tárkány F, Qaim SM. Excitation functions 124Te(p,xn)124,123I reactions from 6 to 31 MeV with special reference to the production of 124I at small cyclotron. Appl Radiat Isot. 1995;46:255–9.
Firouzbakht ML, Schlyer DJ, Wolf AP. The yield of I-124 from different target materials in the 124Te(d,2n)124I reaction and improved recovery method for Te-124. J Labelled Comp Radiopharm. 1994;35:257–9.
Van den Bosch R, De Goeij JJ, Van der Heide JA, Tertoolen JF, Theelen HM, Zegers C. A new approach to target chemistry for the iodine-123 production via the 124Te(p,2n) reaction. Int J Appl Radiat Isot. 1977;28:255–61.
Shikata E, Amano H. Dry distillation of iodine-131 from several tellurium compounds. J Nucl Sci Technol. 1973;10:80–8.
Knust EJ, Dutschka K, Weinreich R. Preparation of 124I solutions after thermodistillation of irradiated 124TeO2 targets. Appl Radiat Isot. 2000;52:181–4.
Förster GJ, Engelbach M, Brockmann J, Reber HJ, Buchholz HG, Mäcke HR, et al. Preliminary data on biodistribution and dosimetry for therapy planning of somatostatin receptor positive tumours: comparison of (86)Y-DOTATOC and (111)In-DTPA-octreotide. Eur J Nucl Med. 2001;28:1743–50.
Rösch F, Qaim SM, Stöcklin G. Production of the positron emitting radioisotope 86Y for nuclear medical applications. Int J Appl Radiat Isot. 1993;44:677–81.
Sachdev DR, Porile NT, Yaffe L. Reactions of Sr-88 with protons of energies 7-85 MeV. Can J Chem. 1967;45:1149–60.
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Schmitz, J. The production of [124I]iodine and [86Y]yttrium. Eur J Nucl Med Mol Imaging 38 (Suppl 1), 4–9 (2011). https://doi.org/10.1007/s00259-011-1782-4
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DOI: https://doi.org/10.1007/s00259-011-1782-4