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Microbial transformation of azaarenes and potential uses in pharmaceutical synthesis

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Abstract

Pyridine, quinoline, acridine, indole, carbazole, and other heterocyclic nitrogen-containing compounds (azaarenes) can be transformed by cultures of bacteria and fungi to produce a variety of new derivatives, many of which have biological activity. In many cases, the microbial biotransformation processes are regio- and stereoselective so that the transformation products may be useful for the synthesis of new candidate drugs.

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Acknowledgments

We thank Dr. Carl E. Cerniglia (NCTR) for valuable comments on the manuscript and Dr. Vitaly Lashin (ACD/Labs, Moscow) for consultations in organic chemistry. The views presented in this article do not necessarily reflect those of the Food and Drug Administration.

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Authors and Affiliations

  1. First Moscow State Medical University of I.M. Sechenov, Moscow, Russia

    Igor A. Parshikov

  2. Moscow State University of M.V. Lomonosov, Moscow, Russia

    Alexander I. Netrusov

  3. National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA

    John B. Sutherland

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  1. Igor A. Parshikov
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  2. Alexander I. Netrusov
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  3. John B. Sutherland
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Correspondence to John B. Sutherland.

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Parshikov, I.A., Netrusov, A.I. & Sutherland, J.B. Microbial transformation of azaarenes and potential uses in pharmaceutical synthesis. Appl Microbiol Biotechnol 95, 871–889 (2012). https://doi.org/10.1007/s00253-012-4220-z

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  • DOI: https://doi.org/10.1007/s00253-012-4220-z

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