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Primary-care prescribing of anti-osteoporotic-type medications following hospitalisation for fractures

  • Pharmacoepidemiology and Prescription
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract

Purpose

We examined the prescribing of antiosteoporotic medications pre- and post hospital admission in patients with fragility fractures as well as factors associated with prescribing of these treatments following admission.

Methods

We identified all patients aged ≥55 years at a large teaching hospital between 2005 and 2008 with a fracture using the Hospital In-Patient Enquiry (HIPE) system. These data were linked to prescribing data from the Health Service Executive Primary Care Reimbursement Services (HSE-PCRS) scheme before and after discharge (821 patients). Logistic regression analysis was used to examine the likelihood of prescription of antiosteoporotic medication pre- and post discharge in relation to year of discharge, age, gender, and type of fracture.

Results

Prescribing of antiosteoporotic treatment before fracture increased from 2.6% [95% confidence interval (CI) 2.23–2.93%] in 2005 to 10.6% (95% CI 9.32–11.86) by 2008, whereas post fracture prescribing increased from 11% (95% CI 9.64–12.36) to 47% (95% CI 43.6–50.3). In patients discharged from hospital in 2007, postfracture prescribing was 31.8% (95% CI 28.66–35.02) at 12 months, increasing to 50.3% (95% CI 46.6–53.9) at 24 months. The highest rate of prescribing was in the 65- to 69-year age group [odds ratio (OR) 8.51, 95% CI 1.75–41.35]. Patients discharged in 2008 were eight times more likely to be treated than patients discharged in 2005 (OR 8.01, 95% CI 4.55–14.09).

Conclusion

The percentage of patients on antiosteoporotic treatment post fracture increased significantly from 2005 to 2008. This may be largely due to the introduction of the Osteoporosis Clinic to the hospital in 2005.

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Acknowledgements

We thank the Health Research Board in Ireland for providing funding for this project. We also thank the HSE-PCRS scheme for providing data on which the study was based, and the staff in the Coding Office at St. James’s Hospital, Dublin, who provided the HIPE data and facilitated the linkage of the data sets.

Conflict of interest

None declared.

Author information

Authors and Affiliations

  1. Department of Pharmacology & Therapeutics, Trinity Centre for Health Sciences, St. James’s Hospital, Dublin 8, Ireland

    Bernie M. McGowan & Kath Bennett

  2. Osteoporosis and Bone Health Clinic, Medicine for the Elderly, St. James’s Hospital, Dublin 8, Ireland

    Joe Marry, J. B. Walsh & Miriam C. Casey

Authors
  1. Bernie M. McGowan
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  2. Kath Bennett
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  3. Joe Marry
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Corresponding author

Correspondence to Bernie M. McGowan.

Appendix 1

Appendix 1

Distribution of the International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes used to identify typical and atypical osteoporotic-type fractures

Table 4 Types of typical and atypical osteoporotic type fractures identified using the tenth revision, clinical modification (ICD-10-CM) codes
Full size table

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McGowan, B.M., Bennett, K., Marry, J. et al. Primary-care prescribing of anti-osteoporotic-type medications following hospitalisation for fractures. Eur J Clin Pharmacol 67, 301–308 (2011). https://doi.org/10.1007/s00228-010-0942-y

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  • DOI: https://doi.org/10.1007/s00228-010-0942-y

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