Abstract
Introduction
Although several psychotropic drugs can acutely induce an anterograde impairment of memory which impedes new learning, they do not produce retrograde impairments, reducing memory for information learned prior to the drug being administered. However, both anterograde and retrograde memory impairments have been reported following an acute dose of morphine in palliative care patients (Kamboj et al., Pain 117:388–395, 2005).
Objective
The present study was designed to determine: (1) whether similar amnestic effects would be found after a single oral dose of either morphine or oxycodone in healthy volunteers, (2) how generalisable such effects were across a broader range of memory tasks and (3) whether men and women showed a differential response.
Materials and methods
A double-blind, placebo-controlled crossover design was used with 18 participants (nine men, nine women) who were administered 10 mg morphine, 5 mg oxycodone and placebo on three separate test days.
Results
On a working memory task, subtle impairments were found in women following both opioids whilst in men only following morphine. On an episodic memory task, women made significantly more source attribution errors after oxycodone and men made more after placebo. Most gender differences were weight related and a range of other measures showed no drug-induced impairments.
Conclusion
We conclude that these standard doses of opioids have only marginal effects on memory. If these findings can be extrapolated to patients with pain, then clinicians can feel confident in prescribing them on an outpatient basis without impacting on patients’ daily functioning.
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References
Bond AJ, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47:211–218
Borgberg FM, Neilson K, Franks J (1996) Experimental pain stimulates respiration and attenuates morphine-induced respiratory depression: a controlled study in human volunteers. Pain 64:123–128
Bruera E, Macmillan K, Hanson J, MacDonald RN (1989) The cognitive effects of the administration of narcotic analgesics in patients with cancer pain. Pain 39:13–16
Cahill L (2006) Why sex matters for neuroscience. Nat Rev Neurosci 7:477–484
Cepada MS, Farrar JT, Baumgarten M, Boston R, Carr DB, Strom BL (2003) Side effects of opioids during short-term administration: effects of age, gender and race. Clin Pharmacol Ther 74:102–112
Coda BA, Hill HF, Hunt EB, Kerr EB, Jacobson RC, Chapman CR (1993) Cognitive and motor function impairments during continuous opioid infusions. Hum Psychopharmacol 8:383–400
Craft R (2003) Sex differences in opioid analgesia: “from mouse to man”. Clin J Pain 19(3):175–186
Curran HV (2000) The psychopharmacology of memory. In: Tulving Craik EF (ed) The Oxford handbook of memory. Oxford University Press, New York, pp 539–556
Curran HV, Weingartner H (2002) Psychopharmacology of memory. In: Baddeley A, Wilson B, Kopelman M (eds) The handbook of memory disorders. New York, Wiley, pp 123–141
Curran HV, Kleckham J, Bearn J, Strang J, Wanigaratne S (2001) Effects of methadone on cognition, mood and craving in detoxifying opioid addicts: a dose-response study. Psychopharmacology 154:153–160
Fillingim RB, Ness TJ (2000) Sex-related hormonal influences on pain and analgesic responses. Neurosci Biobehav Rev 24:485–501
Ghoneim MM (2004) Drugs and human memory (part 2): clinical, theoretical, and methodological issues. Anesthesiology 100:1277–1297
Hubley AM, Tremblay D (2002) Comparability of total score performance on the Rey–Osterrieth complex figure and a modified Taylor complex figure. J Clin Exp Neuropsychol 24(3):370–382
Kamboj SK, Tookman A, Jones JH, Curran HV (2005) The effects of immediate-release morphine on cognitive functioning in patients receiving chronic opioid therapy in palliative care. Pain 117:388–395
Kerr B, Hill H, Coda B, Calogero M, Chpman CR, Hunt E, Buffington V, Mackie A (1991) Concentration-related effects of morphine on cognitions and motor control in human subjects. Neuropsychopharmacology 5:157–166
Lezak MD (1995) Neuropsychological assessment. Oxford University Press, New York
Meador KJ, Taylor HS, Loring DW (1991) Medical College of Georgia (MCG) complex figures. Medical College of Georgia, Augusta
O’Neill WM, Hanks GW, Simpson P, Fallon MT, Jenkins E, Wesnes K (2000) The cognitive and psychomotor effects of morphine in healthy subjects: a randomized controlled trial of repeated (four) oral doses of dextropropoxyphene, morphine, lorazepam and placebo. Pain 85:209–215
Osterrieth PA (1944) Le test de copie d’une figure complexe. Arch Psychol 30:206–356
Reitan RM (1955) The relation of the trail making test to organic brain damage. J Consult Psychol 19:393–394
Sjøgren P, Thomsen AB, Olsen AK (2000) Impaired neuropsychological performance in chronic nonmalignant pain patients receiving long-term oral opioid therapy. J Pain Symptom Manag 19(2):100–108
Spreen O, Strauss E (1998) A compendium of neuropsychological tests: administration, norms and commentary. Oxford University Press, Oxford
The Pain Society (2005) Recommendations for the appropriate use of opioids for persistent non-cancer pain. http://www.britishpainsociety.org/pub_professional.htm#opioids. Accessed 24 Feb, 2005
Veldhuijzen DS, van Wijck AJM, Wille F, Verster JC, Kenemans JL, Kalkman CJ, Olivier B, Volkerts ER (2006) Effect of chronic pain on highway driving performance. Pain 122:28–35
Wilding EL, Rugg MD (1996) An event-related potential study of recognition memory with and without retrieval of source. Brain 119:889–905
Wilson B, Cockburn J, Baddeley A (1985) The Rivermead behavioural memory test. Thames Valley Test Company, Titchfield
Zacny JP, Gutierrez S (2003) Characterising the subjective, psychomotor, and physical effects of oral oxycodone in non-drug-abusing volunteers. Psychopharmacology 170:242–254
Zacny JP, Lichtor SA (2008) Within-subject comparison of the psychopharmacological profiles of oral oxycodone and oral morphine. Psychopharmacology 196:105–116
Zubieta JK, Smith YR, Bueller JA, Xu Y, Kilbourn MR, Jewett DM, Meyer CR, Koeppe RA, Stohler CS (2002) Mu-opioid receptor-mediated antinociceptive responses differ in men and women. J Neurosci 22(12):5100–5107
Acknowledgements
The authors are grateful to Dr. Sunjeev Kamboj for his helpful comments on a draft of this article, to Drs. Andreas Goebel and Amanda Williams for their advice and Jason Wakelin-Smith for providing excellent pharmacy support. They thank University College London (UCL) Graduate School and UCL Clinical Psychology for financial support.
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Friswell, J., Phillips, C., Holding, J. et al. Acute effects of opioids on memory functions of healthy men and women. Psychopharmacology 198, 243–250 (2008). https://doi.org/10.1007/s00213-008-1123-x
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DOI: https://doi.org/10.1007/s00213-008-1123-x