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Association of PLXNA2 polymorphisms with vertebral fracture risk and bone mineral density in postmenopausal Korean population

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Abstract

Introduction

Plexin A2 (PLXNA2) is a receptor that recognizes secreted or membrane-bound semaphorin 3A, which is implicated in neural regulation of bone metabolism.

Materials and Methods

In the present study, we identified 48 genetic polymorphisms in PLXNA2 by resequencing, and 10 single nucleotide polymorphisms (SNPs) were selected for further investigation into their potential involvement in osteoporosis in a postmenopausal population (n=560).

Results

Two SNPs, +14G>A (Gln5Arg) and +183429C>T (Tyr1621Tyr), and Block1-ht2 were associated with risk of vertebral fracture (p=0.01–0.05), and three SNPs, +799G>A (Ala267Thr), +135391G>A, and +190531G>C, were associated with bone mineral density at various femur sites (p=0.003–0.03). Particularly, the minor allele of +14G>A was associated with a protective effect on vertebral fracture and higher lumbar bone mineral density, suggesting that +14G>A may be a useful marker for osteoporosis and its related fracture.

Conclusion

These results provide, for the first time, evidence supporting the association of PLXNA2 with osteoporosis in postmenopausal women.

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Acknowledgements

This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea1 (project number 01-PJ3-PG6-01GN11-0002).

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Authors and Affiliations

  1. National Genome Research Institute, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul, 122-701, South Korea

    J. -Y. Hwang, J. -Y. Lee, M. -H. Park, K. -S. Kim, K. -K. Kim, H. -J. Ryu, J. -K. Lee, B. G. Han, J. W. Kim, B. Oh & K. Kimm

  2. Department of Genetic Epidemiology, SNP Genetics, Inc., Rm 1407, 14th floor, B-dong, WooLim Lion’s Valley, 371-28, Gasan-dong, Geumcheon-gu, Seoul, 153-803, South Korea

    B. L. Park & H. D. Shin

  3. Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, 44-2, Samduk 2-ga, Jung-gu, Daegu, 700-412, South Korea

    T. -H. Kim, J. M. Hong, E. K. Park, D. J. Kim, J. -M. Koh, G. S. Kim & S. -Y. Kim

  4. Department of Pathology, Kyungpook National University School of Dentistry, 188-1, Samduk 2-ga, Jung-gu, Daegu, 700-412, South Korea

    T. -H. Kim & E. K. Park

  5. Division of Endocrinology and Metabolism, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 138-736, South Korea

    D. J. Kim, J. -M. Koh & G. S. Kim

  6. Department of Orthopedic Surgery, Kyungpook National University School of Medicine, 50, Samduk 2-ga, Jung-gu, Daegu, 700-412, South Korea

    S. -Y. Kim

Authors
  1. J. -Y. Hwang
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  2. J. -Y. Lee
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  3. M. -H. Park
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  4. K. -S. Kim
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  5. K. -K. Kim
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  6. H. -J. Ryu
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  7. J. -K. Lee
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  8. B. G. Han
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  9. J. W. Kim
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  10. B. Oh
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  11. K. Kimm
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  12. B. L. Park
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  13. H. D. Shin
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  14. T. -H. Kim
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  15. J. M. Hong
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  16. E. K. Park
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  17. D. J. Kim
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  18. J. -M. Koh
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  19. G. S. Kim
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  20. S. -Y. Kim
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Corresponding author

Correspondence to S. -Y. Kim.

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Hwang, J.Y., Lee, J.Y., Park, M.H. et al. Association of PLXNA2 polymorphisms with vertebral fracture risk and bone mineral density in postmenopausal Korean population. Osteoporos Int 17, 1592–1601 (2006). https://doi.org/10.1007/s00198-006-0126-x

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  • DOI: https://doi.org/10.1007/s00198-006-0126-x

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