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Fecal microbiota transplantation in the ICU: perspectives on future implementations

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References

  1. Zaborin A, Smith D, Garfield K et al (2014) Membership and behavior of ultra-low-diversity pathogen communities present in the gut of humans during prolonged critical illness. MBio 5:e01361-14

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. McDonald D, Ackermann G, Khailova L et al (2016) Extreme dysbiosis of the microbiome in critical illness. mSphere. https://doi.org/10.1128/mSphere.00199-16

    Article  PubMed  PubMed Central  Google Scholar 

  3. Lankelma JM, van Vught LA, Belzer C, Schultz MJ, van der Poll T, de Vos WM, Wiersinga WJ (2017) Critically ill patients demonstrate large interpersonal variation in intestinal microbiota dysregulation: a pilot study. Intensive Care Med 43(1):59–68

    Article  CAS  PubMed  Google Scholar 

  4. Krezalek MA, DeFazio J, Zaborina O, Zaborin A, Alverdy JC (2016) The shift of an intestinal “microbiome” to a “pathobiome” governs the course and outcome of sepsis following surgical injury. Shock 45:475–482

    Article  PubMed  PubMed Central  Google Scholar 

  5. Klingensmith NJ, Coopersmith CM (2016) Fecal microbiota transplantation for multiple organ dysfunction syndrome. Crit Care 20:398

    Article  PubMed  PubMed Central  Google Scholar 

  6. Shimizu K, Ogura H, Hamasaki T, Goto M, Tasaki O, Asahara T, Nomoto K, Morotomi M, Matsushima A, Kuwagata Y, Sugimoto H (2011) Altered gut flora are associated with septic complications and death in critically ill patients with systemic inflammatory response syndrome. Dig Dis Sci 56(4):1171–1177

    Article  PubMed  Google Scholar 

  7. Zilahi G, Artigas A, Martin-Loeches I (2016) What’s new in multidrug-resistant pathogens in the ICU? Ann Intensive Care 6:96

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Taur Y, Xavier JB, Lipuma L, Ubeda C, Goldberg J, Gobourne A, Lee YJ, Dubin KA, Socci ND, Viale A, Perales MA, Jenq RR, van den Brink MR, Pamer EG (2012) Intestinal domination and the risk of bacteremia in patients undergoing allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 55(7):905–914

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Cammarota G, Ianiro G, Tilg H et al (2017) European FMT Working Group. European consensus conference on faecal microbiota transplantation in clinical practice. Gut 66:569–580

    Article  PubMed  PubMed Central  Google Scholar 

  10. McDonald LC, Gerding DN, Johnson S et al (2018) Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 66:987–994

    Article  CAS  PubMed  Google Scholar 

  11. Hocquart M, Lagier JC, Cassir N et al (2018) Early fecal microbiota transplantation improves survival in severe Clostridium difficile infections. Clin Infect Dis 66:645–650

    Article  CAS  PubMed  Google Scholar 

  12. Huttner BD, de Lastours V, Wassenberg M et al (2019) A 5-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: a randomized clinical trial. Clin Microbiol Infect. https://doi.org/10.1016/j.cmi.2018.12.009

    Article  PubMed  Google Scholar 

  13. Rossen NG, Fuentes S, van der Spek MJ, Tijssen JG, Hartman JH, Duflou A, Löwenberg M, van den Brink GR, Mathus-Vliegen EM, de Vos WM, Zoetendal EG, D’Haens GR, Ponsioen CY (2015) Findings from a randomized controlled trial of fecal transplantation for patients with ulcerative colitis. Gastroenterology 149(1):110–118.e4. https://doi.org/10.1053/j.gastro.2015.03.045 (Epub 2015 Mar 30)

    Article  PubMed  Google Scholar 

  14. Ott SJ, Waetzig GH, Rehman A (2017) Efficacy of sterile fecal filtrate transfer for treating patients with Clostrodium difficile infection. Gastroenterology 152(4):799.e7–811.e7

    Article  Google Scholar 

  15. Ramai D, Zakhia K, Ofosu A, Ofori E, Reddy M (2019) Fecal microbiota transplantation: donor relation, fresh or frozen, delivery methods, cost effectiveness. Ann Gastroenterol 32(1):30–38

    PubMed  Google Scholar 

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Acknowledgements

We thank Professor Alessandra Bandera (University of Milan) for the insightful discussions during the course of writing this manuscript.

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Authors and Affiliations

  1. Infectious Diseases Unit, Department of Internal Medicine, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy

    Laura Alagna & Andrea Gori

  2. Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam Infection and Immunity Institute, University of Amsterdam, Amsterdam, The Netherlands

    Bastiaan W. Haak

  3. Department of Pathophysiology and Transplantation, School of Medicine and Surgery, University of Milan, Milan, Italy

    Andrea Gori

Authors
  1. Laura Alagna
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  2. Bastiaan W. Haak
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  3. Andrea Gori
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Corresponding author

Correspondence to Andrea Gori.

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Conflicts of interest

LA has nothing to disclose. BWH has nothing to disclose. AG discolses the receipt of grants/research supports; receipt of honoraria or consultation fees; participation in a company sponsored speaker’s bureau; travel grant/supports: Abbvie, Astellas, BMS, Boeringher, Gilead, Janssen, MSD, Novartis, Pfizer, Roche, ViiV.

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Alagna, L., Haak, B.W. & Gori, A. Fecal microbiota transplantation in the ICU: perspectives on future implementations. Intensive Care Med 45, 998–1001 (2019). https://doi.org/10.1007/s00134-019-05645-7

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  • DOI: https://doi.org/10.1007/s00134-019-05645-7

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