Skip to main content
Log in

What endpoints should be used for clinical studies in acute kidney injury?

  • What's New in Intensive Care
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. KDIGO AKI Workgorup (2012) Kidney disease: improving global outcomes (KDIGO) clinical practice guideline for acute kidney injury. Kidney Int 2:1–141

    Article  Google Scholar 

  2. Kellum JA, Sileanu FE, Murugan R et al (2015) Classifying AKI by urine output versus serum creatinine level. J Am Soc Nephrol 26:2231–2238. doi:10.1681/ASN.2014070724

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kaddourah A, Basu RK, Bagshaw SM et al (2016) Epidemiology of acute kidney injury in critically ill children and young adults. N Engl J Med. doi:10.1056/NEJMoa1611391

    PubMed  Google Scholar 

  4. Liu KD, Vijayan A, Rosner MH et al (2016) Clinical adjudication in acute kidney injury studies: findings from the pivotal TIMP-2*IGFBP7 biomarker study. Nephrol Dial Transpl. doi:10.1093/ndt/gfw238

    Google Scholar 

  5. Fuhrman DY, Kellum JA (2016) Biomarkers for diagnosis, prognosis and intervention in acute kidney injury. Contrib Nephrol 187:47–54. doi:10.1159/000442364

    PubMed  Google Scholar 

  6. Kashani K, Al-Khafaji A, Ardiles T et al (2013) Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care 17:R25. doi:10.1186/cc12503

    Article  PubMed  PubMed Central  Google Scholar 

  7. Koyner JL, Shaw AD, Chawla LS et al (2015) Tissue inhibitor metalloproteinase-2 (TIMP-2) IGF-binding protein-7 (IGFBP7) levels are associated with adverse long-term outcomes in patients with AKI. J Am Soc Nephrol 26:1747–1754. doi:10.1681/ASN.2014060556

    Article  CAS  PubMed  Google Scholar 

  8. Kellum JA, Sileanu FE, Bihorac A et al (2016) Recovery after acute kidney injury. Am J Respir Crit Care Med. doi:10.1164/rccm.201604-0799OC

    PubMed  PubMed Central  Google Scholar 

  9. Chawla LS, Eggers PW, Star RA, Kimmel PL (2014) Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med 371:58–66. doi:10.1056/NEJMra1214243

    Article  PubMed  Google Scholar 

  10. James MT, Dixon E, Roberts DJ et al (2014) Improving prevention, early recognition and management of acute kidney injury after major surgery: results of a planning meeting with multidisciplinary stakeholders. Can J Kidney Health Dis 1:20. doi:10.1186/s40697-014-0020-y

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John A. Kellum.

Ethics declarations

Conflicts of interest

JAK reports consulting fees and/or grant support from Astute Medical, BioPorto, and Medibeacon; AZ reports consulting fees and grant support from Astute Medical; MKN reports consulting fees from Sphingotec.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kellum, J.A., Zarbock, A. & Nadim, M.K. What endpoints should be used for clinical studies in acute kidney injury?. Intensive Care Med 43, 901–903 (2017). https://doi.org/10.1007/s00134-017-4732-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-017-4732-1

Keywords

Navigation