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Temporal changes in allele frequencies in two European F2 flint maize populations under modified recurrent full-sib selection

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Abstract

Selection and random genetic drift are the two main forces affecting the selection response of recurrent selection (RS) programs by changes in allele frequencies. Therefore, detailed knowledge on allele frequency changes attributable to these forces is of fundamental importance for assessing RS programs. The objectives of our study were to (1) estimate the number, position, and genetic effect of quantitative trait loci (QTL) for selection index and its components in the base populations, (2) determine changes in allele frequencies of QTL regions due to the effects of random genetic drift and selection, and (3) predict allele frequency changes by using QTL results and compare these predictions with observed values. We performed QTL analyses, based on restriction fragment length polymorphisms (RFLPs) and simple sequence repeats (SSRs), in 274 F2:3 lines of cross KW1265 × D146 (A × B) and 133 F3:4 lines of cross D145 × KW1292 (C × D) originating from two European flint maize populations. Four (A × B) and seven (C × D) cycles of RS were analyzed with SSRs for significant allele frequency changes due to selection. Several QTL regions for selection index were detected with simple and composite interval mapping. In some of them, flanking markers showed a significant allele frequency change after the first and the final selection cycles. The correlation between observed and predicted allele frequencies was significant only in A × B. We attribute these observations mainly to (1) the high dependence of the power of QTL detection on the population size and (2) the occurrence of undetectable QTL in repulsion phase. Assessment of allele frequency changes in RS programs can be used to detect marker alleles linked to QTL regions under selection pressure.

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Acknowledgments

The present study was supported by a grant from the Deutsche Forschungsgemeinschaft, Grant No. FR 1615/1. The authors gratefully acknowledge Dr. Dietrich Klein and the staff of the Plant Breeding Research Station at Eckartsweier for their skilled conduct of the field trials. We thank KWS SAAT AG and Pioneer Hi-Bred Northern Europe for their support with the SSR screening. We also thank Christine Beuter and Elisabeth Kokai-Kota for the technical assistance with the SSR analyses. We greatly appreciate the critical reading and helpful comments on the manuscript of Dr. Jasmina Muminović.

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Authors and Affiliations

  1. Institute of Plant Breeding, Seed Science, and Population Genetics, University of Hohenheim, 70593, Stuttgart, Germany

    K. C. Falke, C. Flachenecker, A. E. Melchinger, H. P. Maurer & M. Frisch

  2. Institute for Crop Production and Grassland Research, University of Hohenheim, 70593, Stuttgart, Germany

    H. -P. Piepho

Authors
  1. K. C. Falke
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  2. C. Flachenecker
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  3. A. E. Melchinger
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  4. H. -P. Piepho
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  5. H. P. Maurer
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  6. M. Frisch
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Correspondence to A. E. Melchinger.

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Communicated by M. Xu.

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122_2006_443_MOESM1_ESM.pdf

Table 1: Changes in allele frequencies from selection cycles F 2 Syn3 to the final selection cycles C n (A × B: C4; C × D: C7) at all SSR marker loci for parental alleles p and q (p: allele A (A × B) and C (C × D); q: allele B (A × B) and D (C × D)) and for non-parental alleles (v) in population A × B and C × D. (PDF 39 kb)

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Falke, K.C., Flachenecker, C., Melchinger, A.E. et al. Temporal changes in allele frequencies in two European F2 flint maize populations under modified recurrent full-sib selection. Theor Appl Genet 114, 765–776 (2007). https://doi.org/10.1007/s00122-006-0443-7

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  • DOI: https://doi.org/10.1007/s00122-006-0443-7

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