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Kognitive Defizite nach Strahlentherapie von Hirntumoren

Cognitive deficits following brain tumor radiation therapy

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Zusammenfassung

Die Bestrahlung des Gehirns ist ein wichtiges Verfahren in der Behandlung maligner und benigner Erkrankungen mit zerebraler Beteiligung. Der mögliche akute oder chronische Einfluss auf kognitive Leistungen ist für die Alltagskompetenz und Lebensqualität der Patienten wichtig und muss gemeinsam mit einer primären Kontrolle der Erkrankungsprogression differenziert bewertet werden. Die Strahlensensibilität des Hippocampus und seine Bedeutung für Gedächtnisleistungen sind ein Beispiel dafür, dass kognitionsprotektive Strategien im Rahmen der Behandlungsplanung eine hohe Präzision der Therapieverfahren voraussetzen.

Abstract

Brain radiation is an important treatment option for malignant and benign brain diseases. The possible acute or chronic impact of radiation therapy on cognitive performance is important for daily functioning and quality of life. A detailed evaluation of cognitive impairment is important in the context of how to control disease progression. The susceptibility of the hippocampus to radiation-induced neuronal damage and its important role in memory highlight that therapeutic strategies require precision medicine.

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Authors and Affiliations

  1. Neurologische Klinik (Neustadt/Trachau), Städtisches Klinikum Dresden, Industriestr. 40, 01129, Dresden, Deutschland

    M. Buthut

  2. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland

    M. Buthut, R. Haussmann &  M. Donix

  3. Klinik und Poliklinik für Strahlentherapie und Radioonkologie, OncoRay – Nationales Zentrum für Strahlenforschung in der Onkologie, Medizinische Fakultät und Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland

    A. Seidlitz & M. Krause

  4. Deutsches Konsortium für Translationale Krebsforschung (DKTK), Dresden, Deutschland

    M. Krause

  5. Nationales Centrum für Tumorerkrankungen (NCT), Dresden, Deutschland

    M. Krause

  6. Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Deutschland

    M. Krause

  7. Institut für Radioonkologie – OncoRay, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Deutschland

    M. Krause

  8. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Standort Dresden, Arnoldstr. 18, 01307, Dresden, Deutschland

    M. Donix

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  1. M. Buthut
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  2. R. Haussmann
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  3. A. Seidlitz
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  4. M. Krause
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  5. M. Donix
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Correspondence to M. Donix.

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M. Buthut, R. Haussmann, A. Seidlitz, M. Krause und M. Donix geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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Buthut, M., Haussmann, R., Seidlitz, A. et al. Kognitive Defizite nach Strahlentherapie von Hirntumoren. Nervenarzt 89, 423–430 (2018). https://doi.org/10.1007/s00115-017-0423-y

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