Zusammenfassung
Bei der Hashimoto-Thyreoiditis handelt es sich um eine häufige Autoimmunerkrankung der Schilddrüse, die das weibliche Geschlecht bevorzugt. Pathognomonisch für die chronische lymphozytäre Thyreoiditis sind Autoantikörper gegen die Schilddrüsenperoxidase sowie gegen Thyreoglobulin. Laborchemisch liegt bei Diagnosestellung häufig eine latente Hypothyreose vor, die sich infolge der lymphozytären Infiltration der Schilddrüse zu einer substitutionsbedürftigen Hypothyreose mit klassischer klinischer Symptomatik ausbilden kann. Sonographisch zeigt sich die Schilddrüse typischerweise inhomogen und echoarm. Es besteht eine hohe Koinzidenz mit anderen Autoimmunerkrankungen, z.B. Vitiligo, Morbus Addison, Diabetes mellitus Typ 1, z.T. auch als polyglanduläres Syndrom 2.
Abstract
Hashimoto’s thyroiditis is a common autoimmune thyroid disease with preference of female gender. The chronic thyroiditis is characterized by autoantibodies against thyroid peroxidase and thyroglobulin. With manifestation, there is often a subclinical hypothyroidism that finally progresses to a persistent hypothyroidism with typical clinical symptoms and the need of hormonal substitution in succession of the lymphocytic infiltration of the thyroid. The ultrasound of the thyroid shows a hypoechogenic and inhomogeneous parenchyma. Autoimmune thyroiditis is frequently associated with autoimmune disease of other organs, such as vitiligo, Addison’s disease, diabetes mellitus type 1, often in the sense of polyglandular syndrome 2.
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Fink, H., Hintze, G. Die Autoimmunthyreoiditis (Hashimoto-Thyreoiditis): aktuelle Diagnostik und Therapie. Med Klin 105, 485–493 (2010). https://doi.org/10.1007/s00063-010-1082-y
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DOI: https://doi.org/10.1007/s00063-010-1082-y