Abstract
A series of novel flavone incorporated semicarbazides (Y2a–Y2j) was synthesized and characterized by elemental analyses, 1H NMR, 13C NMR, and mass spectral studies. The newly synthesized compounds were screened for their anticonvulsant activity against maximal electroshock seizure model in male wistar rats and compared with the standard drug phenytoin. Compound Y2g i.e., with dimethylamino substitution was found to be most active compound as comparable to standard drug phenytoin and free from in silico neurotoxicity.
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Acknowledgments
The authors are thankful to the BN College of Pharmacy, Udaipur, India for providing laboratory facility for carrying out research work. The authors also deeply appreciate the Punjab University, Punjab, India for providing the spectral studies.
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Sharma, C.S., Verma, T., Singh, H.P. et al. Synthesis, characterization and preliminary anticonvulsant evaluation of some flavanone incorporated semicarbazides. Med Chem Res 23, 4814–4824 (2014). https://doi.org/10.1007/s00044-014-1040-y
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DOI: https://doi.org/10.1007/s00044-014-1040-y