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Analgesic study of novel pyrimidine derivatives linked with coumarin moiety

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Abstract

A novel series of 2-amino-4-(coumarin-3-yl)-6-substituted phenyl pyrimidines (5ah) were synthesized from 3-acetylcoumarin (3). The structures of the synthesized compounds were elucidated by I.R., 1H NMR, 13C NMR, and Mass spectroscopic techniques. The synthesized compounds were screened for in vivo analgesic activities at a dose of 20 mg/kg body weight (b.w). Among them, compounds 5b and 5h exhibited significant analgesic activity comparable with control as well as standard drug diclofenac sodium using acetic acid-induced writhing model.

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Acknowledgment

This research work is financially supported by the Meerut Institute of Engineering & Technology, Meerut, India-250005.

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Correspondence to Jitendra Kumar Gupta.

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Gupta, J.K., Sharma, P.K., Dudhe, R. et al. Analgesic study of novel pyrimidine derivatives linked with coumarin moiety. Med Chem Res 21, 1625–1632 (2012). https://doi.org/10.1007/s00044-011-9675-4

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  • DOI: https://doi.org/10.1007/s00044-011-9675-4

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