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Synthesis of novel porphyrin-based lipids and their antibacterial activity

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Abstract

The purpose of this study was to investigate the antibacterial activity of newly developed cationic amphiphilic lipids having porphyrin as head group against two types of gram-positive bacteria and three types of gram-negative bacteria. The antibacterial activity of quantitatively prepared porphyrin-based amphiphilic lipids is evaluated by the disc-diffusion method against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris. These results are compared with the standard antibacterial activity of chloramphenicol. Both lipids showed antibacterial behaviour against gram-positive and gram-negative bacteria.

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Abbreviations

DCM:

Dichloromethane

DDQ:

2,3-Dichloro-5,6-dicyano-1,4-benzoquinone

ROS:

Reactive oxygen species

S.A:

Staphylococcus aureus

E.C:

Escherichia coli

P.V:

Proteus vulgaris

K.P:

Klebsiella pneumoniae

B.S:

Bacillus subtilis

MPs:

Metalloporphyrins

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Acknowledgment

Financial supports for this work from Council of Scientific and Industrial Research, CSIR (to P. V. Srilakshmi.), Government of India, New Delhi (the doctoral research fellowship to V. Amarnath) is gratefully acknowledged. We sincerely acknowledge the experimental assistance for the studies of antibacterial activity received from G. Kranthi Kumar.

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology Warangal, Warangal, 506004, Andhra Pradesh, India

    Amarnath Velidandi & V. Srilakshmi Patri

  2. Department of Biotechnology, Kakatiya University, Warangal, 506009, Andhra Pradesh, India

    Kranthi Kumar Gadidasu

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  1. Amarnath Velidandi
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  2. Kranthi Kumar Gadidasu
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  3. V. Srilakshmi Patri
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Correspondence to V. Srilakshmi Patri.

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Velidandi, A., Gadidasu, K.K. & Patri, V.S. Synthesis of novel porphyrin-based lipids and their antibacterial activity. Med Chem Res 20, 1068–1073 (2011). https://doi.org/10.1007/s00044-010-9432-0

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  • DOI: https://doi.org/10.1007/s00044-010-9432-0

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