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Functions of skin-resident γδ T cells

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Abstract

The murine epidermis contains resident T cells that express a canonical γδ TCR and arise from fetal thymic precursors. These cells are termed dendritic epidermal T cells (DETC) and use a TCR that is restricted to the skin in adult animals. DETC produce low levels of cytokines and growth factors that contribute to epidermal homeostasis. Upon activation, DETC can secrete large amounts of inflammatory molecules which participate in the communication between DETC, neighboring keratinocytes and langerhans cells. Chemokines produced by DETC may recruit inflammatory cells to the epidermis. In addition, cell–cell mediated immune responses also appear important for epidermal–T cell communication. Information is provided which supports a crucial role for DETC in inflammation, wound healing, and tumor surveillance.

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Abbreviations

DETC:

Dendritic epidermal T cells

JAML:

Junctional adhesion molecule-like protein

CAR:

Coxsackie and adenovirus receptor

CS:

Delayed-type contact hypersensitivity

GVHD:

Graft versus host disease

TLR:

Toll-like receptor

Rae-1:

Retinoic acid early transcript 1

Mult1:

UL-16 binding protein-like transcript-1

ITAM:

Immunoreceptor tyrosine-based activation motif

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Acknowledgments

The authors are supported by grants from the National Institutes of Health (AI007244, AI64811, AI36964, and GM80301), L’Oreal, Deutsche Dermatologische Gesellschaft and the Arbeitsgemeinschaft Dermatologische Forschung.

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  1. Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, IMM-8, La Jolla, CA, 92037, USA

    Amanda S. MacLeod & Wendy L. Havran

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  1. Amanda S. MacLeod
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  2. Wendy L. Havran
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Correspondence to Wendy L. Havran.

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MacLeod, A.S., Havran, W.L. Functions of skin-resident γδ T cells. Cell. Mol. Life Sci. 68, 2399–2408 (2011). https://doi.org/10.1007/s00018-011-0702-x

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