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Associations of IL1RAP and IL1RL1 gene polymorphisms with obesity and inflammation mediators

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Abstract

Objectives

Obesity is attributable to high free fatty acids, ER stress, oxidative stress and inflammation. The expression of IL-33, IL-1RL1 and IL-1RAP gene was observed in human visceral white fats, pre-adipocytes and adipocytes. The aim of this study was to determine whether IL1RAP and IL1RL1 gene variants were associated with obesity and inflammation mediators.

Methods

3 SNPs of IL1RAP (rs9990107, rs3836449 and rs9290936) and 11 SNPs of IL1RL1 (rs3771180, rs13431828, rs3214363, rs1420101, rs12905, rs3771175, rs3821204, rs12712142, rs10204137, rs4988958, and rs10206753) were genotyped for 175 obesity (BMI ≥ 25) and 358 non-obesity (BMI < 25.0) subjects. The genotype of SNPs was determined by the Axiom Genome-Wide Human Assay.

Results

The allele and genotype frequencies of 2 SNPs in the IL1RAP gene (rs9990107 and rs3836449) and 11 SNPs in the IL1RL1 gene (rs3771180, rs13431828, rs3214363, rs1420101, rs12905, rs3771175, rs3821204, rs12712142, rs10204137, rs4988958 and rs10206753) were significantly associated between the obesity and non-obesity groups. The two haplotypes (GCTTATGAATT and TT-CGACCGCC) in block1 were associated with obesity. In the non-obesity group, genotype frequencies of rs3771180, rs13431828, rs3214363, rs10204137, rs4988958 and rs10206753 SNPs of IL1RL1 showed significant differences in the dominant models in lymphatic cell percentage. The genotype frequencies of rs1420101, rs21905, rs3821024 and rs12712142 SNPs of IL1RL1 showed significant differences in the dominant models in eosinophil percentage.

Conclusions

Our results suggest that IL1RAP and IL1RL1 gene polymorphisms may be associated with obesity and inflammation mediators.

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References

  1. World Health Organization: Obesity and overweight. World Health Organization Media centre [Serial online]. 2018. https://www.who.int/mediacentre/factsheets/fs311/en/.

  2. Hruby A, Hu FB. The epidemiology of obesity: a big picture. Pharmacoeconomics. 2015;33:673–89.

    Article  Google Scholar 

  3. Korea Centers for Disease Control and Prevention: Korea Health Statistics 2016. Korea National Health and Nutrition Examination Survey (KNHANES VII-1). Seoul: Korea Centers for Disease Control and Prevention; 2017.

  4. Choi J, Park S, Kwon TK, Sohn SI, et al. Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1/angiotensin II axis. Int J Obes (Lond). 2017;41:1702–9.

    Article  CAS  Google Scholar 

  5. Boon MR, Bakker LE, van der Linden RA, et al. High prevalence of cardiovascular disease in South Asians: central role for brown adipose tissue? Crit Rev Clin Lab Sci. 2015;8:1–8.

    Google Scholar 

  6. Shaw E, Farris M, McNeil J, et al. Obesity and endometrial cancer. Recent Results Cancer Res. 2016;208:107–36.

    Article  CAS  Google Scholar 

  7. Herlevic VC, Mowad R, Miller JK, et al. Breast cancer outcomes in a population with high prevalence of obesity. J Surg Res. 2015;198:371–6.

    Article  Google Scholar 

  8. Rethorst CD1, Bernstein I, Trivedi MH. Inflammation, obesity, and metabolic syndrome in depression: analysis of the 2009–2010 National Health and Nutrition Examination Survey (NHANES). J Clin Psychiatry. 2014;75:e1428–32.

    Article  Google Scholar 

  9. Kim HH, Baek JM, Hwang JU, et al. A comparison of the psychological characteristics of obese people: the association between depression, body shape dissatisfaction and self-esteem of surgical treatment group and no treatment group. Korean J Obes. 2014;23:32–40.

    Article  Google Scholar 

  10. Albuquerque D, Nóbrega C, Manco L, et al. The contribution of genetics and environment to obesity. Br Med Bull. 2017;123:159–73.

    Article  Google Scholar 

  11. Wu J, Liu Z, Meng K, Zhang L. Association of adiponectin gene (ADIPOQ) rs2241766 polymorphism with obesity in adults: a meta-analysis. PLoS ONE ONE. 2014;9:e95270.

    Article  Google Scholar 

  12. Kitamoto A, Kitamoto T, Mizusawa S, et al. NUDT3 rs206936 is associated with body mass index in obese Japanese women. Endocr J. 2013;60:991–1000.

    Article  CAS  Google Scholar 

  13. Mardan-Nik M, Pasdar A, Jamialahmadi K, et al. Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity. Ann Hum Biol. 2016;43:542–6.

    Article  Google Scholar 

  14. Yu GI, Ha E, Park SH, et al. Association of tumor necrosis factor-α (TNF-α) promoter polymorphisms with overweight/obesity in a Korean population. Inflamm Res. 2011;60:1099–105.

    Article  CAS  Google Scholar 

  15. Joffe YT, van der Merwe L, Carstens M, et al. Tumor necrosis factor-alpha gene-308 G/A polymorphism modulates the relationship between dietary fat intake, serum lipids, and obesity risk in black South African women. J Nutr. 2010;140:901–7.

    Article  CAS  Google Scholar 

  16. Yu GI, Jun SE, Shin DH. Associations of VCAM-1 gene polymorphisms with obesity and inflammation markers. Inflamm Res. 2017;66:217–25.

    Article  CAS  Google Scholar 

  17. Cyrus C, Ismail MH, Chathoth S, et al. Analysis of the impact of common polymorphisms of the FTO and MC4R genes with the risk of severe obesity in Saudi Arabian population. Genet Test Mol Biomark. 2018;22:170–7.

    Article  CAS  Google Scholar 

  18. Seijkens T, Kusters P, Chatzigeorgiou A, et al. Immune cell crosstalk in obesity: a key role for costimulation? Diabetes. 2014;63:3982–91.

    Article  CAS  Google Scholar 

  19. Bai Y, Sun Q. Macrophage recruitment in obese adipose tissue. Obes Rev. 2015;16:127–36.

    Article  CAS  Google Scholar 

  20. Blom L, Poulsen LK. IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures. J Immunol. 2012;189:4331–7.

    Article  CAS  Google Scholar 

  21. Savenije OE, John JM, Granell R, et al. Association of IL33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood. J Allergy Clin Immunol. 2014;134:170–7.

    Article  CAS  Google Scholar 

  22. Inoue H, Ito I, Niimi A, et al. Association of interleukin 1 receptor-like 1 gene polymorphisms with eosinophilic phenotype in Japanese adults with asthma. Respir Investig. 2017;55:338–47.

    Article  Google Scholar 

  23. Griesenauer B, Paczesny S. The ST2/IL-33 axis in immune cells during inflammatory diseases. Front Immunol. 2017;8:475.

    Article  Google Scholar 

  24. Zeyda M, Wernly B, Demyanets S, et al. Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue. Int J Obes (Lond). 2013;37:658–65.

    Article  CAS  Google Scholar 

  25. Asia-Pacific Steering Committee. The Asia-Pacific perspective: redefining obesity and its treatment. Sydney: Health Communications Australia; 2000.

    Google Scholar 

  26. Wood IS, Wang B, Trayhurn P. IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes. Biochem Biophys Res Commun. 2009;19(384):105–9.

    Article  Google Scholar 

  27. Miller AM. Role of IL-33 in inflammation and disease. J Inflamm (Lond). 2011;8:22.

    Article  CAS  Google Scholar 

  28. Mortha A, Burrows K. Cytokine networks between innate lymphoid cells and myeloid cells. Front Immunol. 2018;9:191.

    Article  Google Scholar 

  29. Chan BCL, Lam CWK, Tam LS, et al. IL33: roles in allergic inflammation and therapeutic perspectives. Cardiovasc Res. Front Immunol. 2019;10:364.

    Article  CAS  Google Scholar 

  30. Altara R, Ghali R, Mallat Z, et al. Conflicting vascular and metabolic impact of the IL-33/sST2 axis. Cardiovasc Res. 2018;114:1578–94.

    Article  CAS  Google Scholar 

  31. Bozaoglu K, Attard C, Kulkarni H, et al. Plasma levels of soluble interleukin 1 receptor accessory protein are reduced in obesity. J Clin Endocrinol Metab. 2014;99:3435–43.

    Article  CAS  Google Scholar 

  32. Savenije OE, Kerkhof M, Reijmerink NE, et al. Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood. J Allergy Clin Immunol. 2011;127:750–6.

    Article  CAS  Google Scholar 

  33. Queiroz GA, Costa RS, Alcantara-Neves NM, et al. IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population. Int J Immunogenet. 2017;44:51–61.

    Article  CAS  Google Scholar 

  34. Guo C, Zhang L, Nie L, et al. Association of polymorphisms in the MyD88, IRAK4 and TRAF6 genes and susceptibility to type 2 diabetes mellitus and diabetic nephropathy in a southern Han Chinese population. Mol Cell Endocrinol. 2016;429:114–9.

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korean Government (MSIP) (No. 2014R1A5A2010008).

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Authors and Affiliations

  1. Department of Preventive Medicine, School of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-Gu, Daegu, 42601, South Korea

    Gyeong Im Yu & Dong Hoon Shin

  2. Department of Physiology, School of Medicine, Keimyung University, 1095 Dalgubeoldaero, Dalseo-Gu, Daegu, 42601, South Korea

    Dae Kyu Song

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  1. Gyeong Im Yu
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Correspondence to Dong Hoon Shin.

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Communicated by Dr. John Di Battista.

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Yu, G.I., Song, D.K. & Shin, D.H. Associations of IL1RAP and IL1RL1 gene polymorphisms with obesity and inflammation mediators. Inflamm. Res. 69, 191–202 (2020). https://doi.org/10.1007/s00011-019-01307-y

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  • DOI: https://doi.org/10.1007/s00011-019-01307-y

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