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Disseminated infection withSaccharomyces kluyveri in a patient with AIDS

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Abstract

A 47-year-old man with acquired immune deficiency syndrome was found to have disseminatedSaccharomyces kluyveri infection. The yeast was isolated from blood and cerebrospinal fluid. An autopsy revealed the presence of the microorganism in many organs including liver, kidneys, pancreas, spleen, lung, and brain. The case confirms a potential pathogenicity of yeasts of the genusSaccharomyces in patients with profound immune deficiency, especially in advanced HIV infection.

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References

  1. Curry, C. R., Quie, P. G.: Fungal septicemia in patients receiving parenteral hyperalimentation. N. Engl. J. Med 285 (1971) 1221–1225.

    Article  PubMed  CAS  Google Scholar 

  2. Kiehn, T. E., Edwards, F. F., Armstrong, D.: The prevalence of yeasts in clinical specimens from cancer patients. Am. J. Clin. Pathol. 73 (1980) 518–521.

    PubMed  CAS  Google Scholar 

  3. Krčméry, V. Jr.,Kunova, A., Mardiak, J.: NosocomialCryptococcus laurentii fungemia in a bone marrow transplant patient after prophylaxis with ketoconazole successfully treated with oral fluconazole. Infection 25 (1997) 130.

    Article  PubMed  Google Scholar 

  4. Louria, D. B., Blevins, A., Armstrong, D., Burdick, R., Lieberman, P.: Fungemia caused by “nonpathogenic” yeasts. Arch. Intern. Med. 119 (1967) 247–252.

    Article  PubMed  CAS  Google Scholar 

  5. Meunier-Carpentier, F., Kiehn, T. E., Armstrong, D.: Fungemia in the immunocompromised host—changing patterns, antigenemia, high mortality. Am. J. Med. 71 (1981) 363–370.

    Article  PubMed  CAS  Google Scholar 

  6. Eng, R. H., Drehmel, R., Smith, S. M., Goldstein, E. J.:Saccharomyces cerevisiae infections in man. Sabouraudia 22 (1984) 403–407.

    PubMed  CAS  Google Scholar 

  7. Eschete, M. L., West, B. C.:Saccharomyces cerevisiae septicemia. Arch. Intern. Med. 140 (1980) 1539.

    Article  PubMed  CAS  Google Scholar 

  8. Oriol, A., Ribera, J.-M., Arnal, J., Milla, F., Battle, M., Feliu, E.:Saccharomyces cerevisiae septicemia in a patient with myelodysplastic syndrome. Am. J. Hematol. 43 (1993) 325–326.

    Article  PubMed  CAS  Google Scholar 

  9. de Hoog, G. S., Guarro, J.: Endomycetous yeasts. GenusSaccharomyces. In: Atlas of clinical fungi. Centraalbureau voor Schimmelcultures. Baarn and Delft, The Netherlands/Universitat Rovira i Virgili, Reus, Spain 1995, p. 238.

    Google Scholar 

  10. Caumont, A. B., Jamieson, G. A., Pichuantes, S., Nguyen, A. T., Litvak, S., Dupont, C.: Expression of functional HIV-1 integrase in the yeastSaccharomyces cerevisiae leads to the emergence of a lethal phenotype: potential use for inhibitor screening. Curr. Genet. 29 (1996) 503–510.

    PubMed  CAS  Google Scholar 

  11. Cairoli, R., Marenco, P., Perego, R., de Catalgo, F.:Saccharomyces cerevisiae fungemia with granulomas in the bone marrow in a patient undergoing BMT. Bone Marrow Transplant. 15 (1995) 785–786.

    PubMed  CAS  Google Scholar 

  12. Chertow, G. M., Marcantonio, E. R., Wells, R. G.:Saccharomyces cerevisiae empyema in a patient with esophago-pleural fistula complicating variceal sclerotherapy. Chest 99 (1991) 1518–1519.

    Article  PubMed  CAS  Google Scholar 

  13. Cimolai, N., Gill, M. J., Church, D.:Saccharomyces cerevisiae fungemia: case report and review of the literature. Diagn. Microbiol. Infect. Dis. 8 (1987) 113–117.

    Article  PubMed  CAS  Google Scholar 

  14. Dougherty, S. H., Simmons, R. L.: Postoperative peritonitis caused bySaccharomyces cerevisiae. Arch. Surg. 117 (1982) 248–249.

    PubMed  CAS  Google Scholar 

  15. Feld, R., Fornasier, V. L., Bombardier, C., Hastings, D. E.: Septic arthritis due toSaccharomyces species in a patient with chronic rheumatoid arthritis. J. Rheumatol. 9 (1982) 627–640.

    Google Scholar 

  16. Rubinstein, E., Noriega, E. R., Simberkoff, M. S., Holzman, R., Rahal, J. J. Jr.: Fungal endocarditis: analysis of 24 cases and review of the literature. Medicine 54 (1975) 331–334.

    PubMed  CAS  Google Scholar 

  17. Stein, P. D., Folkens, A. T., Hruska, K. A.:Saccharomyces fungemia. Chest 58 (1970) 173–175.

    Article  PubMed  CAS  Google Scholar 

  18. Jensen, D. P., Smith, D. L.: Fever of unknown origin secondary to brewer’s yeast ingestion. Arch. Intern. Med. 136 (1976) 332–333.

    Article  PubMed  CAS  Google Scholar 

  19. Wilson, J. D., Jones, B. M., Kinghorn, G. R.: Bread-making as a source of vaginal infection withSaccharomyces cerevisiae. Report of a case in a woman and apparent transmission to her partner. Sex. Transm. Dis. 15 (1988) 35–36.

    PubMed  CAS  Google Scholar 

  20. Sethi, N., Mandell, W.:Saccharomyces fungemia in a patient with AIDS. N. Y. State J. Med. 88 (1988) 278–279.

    PubMed  CAS  Google Scholar 

  21. Tawpik, O. W., Papasian, C. J., Dixon, A. Y., Potter, L. M.:Saccharomyces cerevisiae pneumonia in a patient with acquired immune deficiency syndrome. J. Clin. Microbiol. 27 (1989) 1689–1691.

    Google Scholar 

  22. Barnett, J. A., Payne, R. W., Yarrow, D.: Description of the species:Saccharomyces kluyveri. In: Yeasts—characteristics and identification (2nd ed.). Cambridge University Press, Cambridge 1990, p. 600.

    Google Scholar 

  23. Pletincx, M., Legein, J., Vandenplas, Y.: Fungemia withSaccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J. Pediatr. Gastroenterol. Nutr. 21 (1995) 113–115.

    Article  PubMed  CAS  Google Scholar 

  24. Reiersol, S., Hoel, J.:Saccharomyces carlsbergensis, possibly a pathogen. Acta Pathol. Microbiol. Scand. 44 (1958) 313–318.

    Article  PubMed  CAS  Google Scholar 

  25. Zunic, P., Lacotte, J., Pegoix, M., Buteux, G., Leroy, G., Mosquet, B., Moulin, M.: Fongémie àSaccharomyces boulardii. A propos d’un cas. Thérapie 46 (1991) 498–499.

    PubMed  CAS  Google Scholar 

  26. de Hoog, G. S., Guarro, J.: Deep mycoses. In: Atlas of clinical fungi. Centraalbureau voor schimmelcultures. Baarn and Delft, The Netherlands/Universitat Rovira i Virgili. Reus, Spain 1995, pp. 21–26.

    Google Scholar 

  27. Berg, R., Bernasconi, P., Fowler, D., Gautreaux, M.: Inhibition ofCandida albicans translocation from the gastrointestinal tract of mice by oral administration ofSaccharomyces boulardii. J. Infect. Dis. 168 (1993) 1314–1318.

    PubMed  CAS  Google Scholar 

  28. Born, P., Lersch, C., Zimmerhackl., B., Classen, M.:Saccharomyces boulardii—Therapie HIV-assoziierter Durchfälle. Dtsch. Med. Wochenschr. 118 (1993) 765.

    PubMed  CAS  Google Scholar 

  29. Krause, W., Matheis, H., Wulf, K.: Fungaemia and funguria after oral administration ofCandida albicans. Lancet i (1969) 598–599.

    Article  Google Scholar 

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Authors and Affiliations

  1. Dept of Infectious Diseases, Pomeranian Madical Academy, ul. Arkońska 4, PL-71-455, Szczecin, Poland

    M. Pynka M.D., A. Wnuk M.D., D. Bander M.D., M. Syczewska M.D. & A. Boroń M.D., Ph.D.

  2. Dept of Microbiology, Regional Hospital, Szczecin, Poland

    B. Prost M. Sc.

  3. Dept. of Pathology, Regional Hospital, Szczecin, Poland

    S. Wrzecion M.D.

Authors
  1. M. Pynka M.D.
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  2. A. Wnuk M.D.
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  3. D. Bander M.D.
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  4. M. Syczewska M.D.
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  5. A. Boroń M.D., Ph.D.
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Pynka, M., Wnuk, A., Bander, D. et al. Disseminated infection withSaccharomyces kluyveri in a patient with AIDS. Infection 26, 184–186 (1998). https://doi.org/10.1007/BF02771850

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  • DOI: https://doi.org/10.1007/BF02771850

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