Abstract
Relapse of chronicT. brucei infections was completely prevented by treating with either diminazene aceturate (Berenil) at 40 mg/kg or suramin (Germanin) at 20mg/kg followed by four doses of the 2-substituted 5-nitroimidazole (Fexinidazole)(Hoe 239). None of these drugs administered singly elicited 100% permanent cures although a high percentage of the mice were cured with four doses of Fexinidazole at 250 mg/kg.
A single dose of 20 mg/kg suramin followed by four daily doses of 30 mg/kg Fexinidazole will effectively eliminate all the trypanosomes from the brains of chronically infected mice.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Freireich EJ, Gehan EA, Rall DP, Schmidt LH, Skipper HE (1966) Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chem Rpts 50:319–244
Jennings FW, Gray GD (1983) Relapsed parasitaemia following chemotherapy of chronicT. brucei infections in mice and its relation to cerebral trypanosomes. (Karger, Basel) Contr Microbiol Immunol 7:147–154
Jennings FW, Whitelaw DD, Urquhart GM (1977) The relationship between duration of infection withTrypanosoma brucei in mice and the efficacy of chemotherapy. Parasitology 75:143–153
Jennings FW, Urquhart GM, Murray PK, Miller BM (1980) “Berenil” and nitroimidazole combinations in the treatment ofTrypanosoma brucei infection with central nervous system involvement. Intern J Parasitol 10:27–32
Jennings FW, Gray GD, Urquhart GM (1982) The use of Erlangen diamidine 98/202 in relapsingTrypanosoma brucei infections in mice. Trans Roy Soc Trop Med Hyg 76:204–207
Jennings FW, Urquhart GM, Murray PK, Miller BM (1983) Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murineTrypanosoma brucei infections with central nervous system involvement. Trans Roy Soc Trop Med Hyg (In press)
Raether W, Deutschlander N (1979) Fexinidazole (Hoe 239) a new 5-nitroimidazole with a marked action againstTrypanosoma cruzi in NMRI-mice. Congresso Internacional sobre Doenca de Chagas, Rio de Janeiro, Brasil, p 142
Raether W, Seidenath H (1983) The activity of fexinidazole (HOE 239) against experimental infections withTrypanosoma cruzi, trichomonads andEntamoeba histolytica. Ann Trop Med Parasitol 77:13–26
Richle RW, Raaflaub J (1980) Differences of effective antitrypanosomal dosages of benznidazole in mice and man: Chemotherapeutic and pharmacokinetic results. Acta Trop 37:257–261
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jennings, F.W., Urquhart, G.M. The use of the 2 substituted 5-nitroimidazole, fexinidazole (Hoe 239) in the treatment of chronicT. brucei infections in mice. Z. Parasitenkd. 69, 577–581 (1983). https://doi.org/10.1007/BF00926669
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00926669