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Homology of Saccharomyces cerevisiae ADH4 to an iron-activated alcohol dehydrogenase from Zymomonas mobilis

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Summary

Insertion of the transposable element Ty at the ADH4 locus results in increased levels of a new alcohol dehydrogenase (ADH) activity in Saccharomyces cerevisiae. The DNA sequence of this locus has been determined. It contains a long open reading frame which is not homologous to the other ADH isozymes that have been characterized in S. cerevisiae nor does it show obvious homology to Drosophila ADH. The hypothetical ADH does, however, show strong homology to the sequence of an iron-activated ADH from the bacterium Zymomonas mobilis. Thus ADH4 appears to encode an ADH structural gene which, along with the Zymomonas enzyme, may define a new family of alcohol dehydrogenases.

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Author notes

  1. Valerie M. Williamson

    Present address: Division of Nematology, University of California, 95616, Davis, CA, USA

  2. Charlotte E. Paquin

    Present address: Department of Biological Sciences, University of Cincinnati, 45221, Cincinnati, OH, USA

Authors and Affiliations

  1. ARCO Plant Cell Research Institute, 6560 Trinity Court, 94568, Dublin, CA, USA

    Valerie M. Williamson & Charlotte E. Paquin

Authors
  1. Valerie M. Williamson
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  2. Charlotte E. Paquin
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Additional information

Communicated by G.R. Fink

Now The Plant Cell Research Institute, Inc., 6560 Trinity Court, Dublin, CA 94568, USA

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Williamson, V.M., Paquin, C.E. Homology of Saccharomyces cerevisiae ADH4 to an iron-activated alcohol dehydrogenase from Zymomonas mobilis . Molec Gen Genet 209, 374–381 (1987). https://doi.org/10.1007/BF00329668

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  • DOI: https://doi.org/10.1007/BF00329668

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