Summary
The distribution of serotonin-immunoreactive cells in the lung of 4 species of reptiles was investigated. Serotonin-containing cells were found forming groups in the interconnecting septa in all 4 species studied, and also as solitary cells in Testudo graeca and Mauremys caspica. Serotonin-containing cells were also localized in the intramural ganglia of Pseudemys scripta elegans and Testudo graeca. The present study confirms that serotonin is widely distributed in the lung of vertebrates.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Becker K, Kathleen G, Monaghan BS, Silva OL (1980) Immunocytochemical localization of calcitonin in Kulchitsky cells of human lung. Arch Pathol Lab Med 104:196–198
Cutz E, Chan W, Track NS (1981) Bombesin, calcitonin and leuenkephalin immunoreactivity in endocrine cells of human lung. Experientia 37:765–767
Cutz E, Goniakowska-Witalinska L, Chan W (1986) An immunohistochemical study of regulatory peptides in lungs of amphibians. Cell Tissue Res 244:277–233
Dayer AM, De Mey J, Will JA (1985) Localization of somatostatin-, bombesin-, and serotonin-like immunoreactivity in the lung of the fetal Rhesus monkey. Cell Tissue Res 239:621–625
Diaugustine RP, Sonstegard KS (1984) Neuroendocrine-like (small granule) epithelial cells of the lung. Environ Health Perspect 55:271–295
Ghatei MA, Sheppard MN, O'Shaughnessy DJ, Adrian TE, McGregor GP, Polak JM, Bloom SR (1982) Regulatory peptides in the mammalian respiratory tract. Endocrinology 111:1248–1254
Goniakowska-Witalinska L (1980) Endocrine-like cells in the lungs of the newt, Triturus alpestris Laur. Cell Tissue Res 210:521–524
Goniakowska-Witalinska L (1981) Neuroepithelial bodies in the lung of the tree frog Hyla arborea L. A scanning and transmision electron microscopic study. Cell Tissue Res 217:435–441
Gosney JR, Sissons MCJ (1985) Widespread distribution of bronchopulmonary endocrine cells immunoreactive for calcitonin in the lung of the normal adult rat. Thorax 40:194–198
Grimelius L (1968) A silver nitrate stain for α2 cells in human pancreatic islets. Acta Soc Med Upsala 73:243–270
Lauweryns JM, Cokelaere M (1973) Hypoxia sensitive neuroepithelial bodies. Intrapulmonary secretory neuroreceptors, modulated by the CNS. Z Zellforsch 145:521–540
Lauweryns JM, Cokelaere M, Theunynck P (1973) Serotonin producing neuroepithelial bodies in rabbit respiratory mucosa. Science 180:410–413
Lauweryns JM, Bock V, Verhofstad AAJ, Steinbusch HWM (1982) Immunohistochemical localization of serotonin in intrapulmonary neuro-epithelial bodies. Cell Tissue Res 226:215–223
Lauweryns JM, Ranst LV, Verhofstad AAJ (1986) Ultrastructural localization of serotonin in the intrapulmonary neuroepithelial bodies of neonatal rabbits by use of immuno-electron microscopy. Cell Tissue Res 243:455–459
Linnoila RI, Becker KL, Silva OM, Snider RH, Moore CH F (1984) Calcitonin as a marker for diethylnitrosamine-induced pulmonary endocrine cell hyperplasia in hamsters. Lab Invest 51:39–45
Marchewsky AM, Kleinerman J (1982) Immunocytochemical studies of APUD cells in airways. Arch Pathol Lab Med 106:400–403
McLelland J, Mcfarlane CJ (1986) Solitary granular endocrine cells and neuroepithelial bodies in the lungs of the ringed turtle dove (Streptopelia risoria). J Anat 147:83–93
Pastor LM, Ballesta J, Hernández F, Pérez Tomás R, Zuasti A, Ferrer C (1987) A microscopic study of the tracheal epithelium of Testudo graeca and Pseudemys scripta elegans. J Anat (In press)
Polak JM, Bloom SR (1982) Regulatory peptides and neuron-specific enolase in the respiratory tract of man and other mammals. Exp Lung Res 3:313–328
Ravazzola M, Orci L, Girgis SI, Galan FG, McIntyre I (1981) The lung is the major organ source of calcitonin in the lizard. Cell Biol Int Rep 5:937–944
Rogers DC, Haller CJ (1978) Innervation and cytochemistry of the neuroepithelial bodies in the ciliated epithelium of the toad lung (Bufo marinus). Cell Tissue Res 195:395–410
Scheuermann dW, De Groodt-Lasseel MHA, Stilman C (1984) A light and fluorescence cytochemical and electron microscopic study of granule-containing cells in the intrapulmonary ganglia of Pseudemys scripta elegans. Am J Anat 171:377–394
Scheuermann DW, De Groodt-Lasseel MHA, Stilman C, Meisters ML (1983) A correlative light-, fluorescence and electron microscopic study of neuroepithelial bodies in the lung of the red-eared turtle Pseudemys scripta elegans. Cell Tissue Res 234:249–269
Sheppard MN, Marangos PJ, Bloom SR, Polak JM (1984) Neuron specific enolase: A marker for the early development of nerves and endocrine cells in the human lung. Life Sci 34:265–271
Sorokin SP, Hoyt RF, Grant MM (1983) Comparative biology of small granule cells and neuroepithelial bodies in the respiratory system: short review. Am Rev Respir Dis [Suppl] 128:s26-s31
Stahlman MJT, Kasselberg AG, Orth DN, Gray ME (1985) Ontogeny of neuroendocrine cells in human fetal lung. II An immunohistochemical study. Lab Invest 52:52–60
Sternberger LA (1979) The unlabeled antibody peroxidase-antiperoxidase (PAP) method. In: Sternberger (ed) Immunocytochemistry. John Wiley & Sons, New York, pp 104–169
Tsutsumi Y, Osamura Y, Watanabe K, Yasnaihara N (1983) Immunohistochemical studies on gastrin-releasing peptide and adrenocorticotropic hormone-containing cells in the human lung. Lab Invest 48:623–631
Verhofstad AAJ, Steinbusch HWM, Penke B, Varga J, Joosten HWJ (1981) Serotonin-immunoreactive cells in the superior cervical ganglion of the rat. Evidence for the existence of separate serotonin- and catecholamine-containing small ganglionic cells. Brain Res 156:75–82
Wasano K, Yamamoto T (1978) Monoamine-containing granulated cells in the frog lung. Cell Tissue Res 193:201–209
Wasano K, Yamamoto T (1979) APUD-type receptor-secretory cells in the chicken lung. Cell Tissue Res 201:197–205
Wharton J, Polak JM, Bloom SR, Ghatei MA, Solcia E, Brown ME, Pearse AGE (1978) Bombesin-like immunoreactivity in the lung. Nature 273:769–770
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pastor, L.M., Ballesta, J., Perez-Tomas, R. et al. Immunocytochemical localization of serotonin in the reptilian lung. Cell Tissue Res. 248, 713–715 (1987). https://doi.org/10.1007/BF00216504
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00216504