Summary
Inactivation of one or more tumor-suppressor genes on the short arm of chromosome 11 is thought to play a role in the etiology of Wilms' tumor. A candidate gene, QM, was recently isolated by subtractive hybridization between a tumorigenic cell line (deleted for part of 11p) and a non-tumorigenic cell line (the tumorigenic cell line carrying an extra t(X;11)copy). We show here with an exon-specific polymerase chain reaction that the genomic homolog of the QM cDNA is located in the G6PD-color vision genes region in Xq28. No homologous sequences could be detected on 11p. Our experiments indicate that the QM gene is not involved in the suppression of Wilms' tumor.
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van den Ouweland, A.M.W., Verdijk, M., Mannens, M.M.A.M. et al. The QM gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor. Hum Genet 90, 144–146 (1992). https://doi.org/10.1007/BF00210759
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DOI: https://doi.org/10.1007/BF00210759