Abstract
Metabolic Control Analysis (MCA) is a theoretical framework for investigating and understanding control and regulation of metabolism. In particular, it relates the properties of metabolic systems to the kinetic characteristics of the component enzymes. However, not all of the properties of enzymes strongly influence the be-haviour of metabolic systems, some of which is generic and is reviewed here. It is argued that MCA is an important component of systems biology that still has much to offer in the development of predictive and integrative biology and the linking of genome to phenotype.
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Fell, D.A. Metabolic Control Analysis. In: Alberghina, L., Westerhoff, H. (eds) Systems Biology. Topics in Current Genetics, vol 13. Springer, Berlin, Heidelberg. https://doi.org/10.1007/b137745
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DOI: https://doi.org/10.1007/b137745
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