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Generation of landomycin D-producing strainStreptomyces globisporus LD3

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Abstract

Rhodinosyl transferase geneIndGT4, governing the conversion of the disaccharide oligoketide (‘polyketide’) landomycin D into a trisaccharide derivative landomycin E, was deleted inStreptomyces globisporus 1912 genome. Possible resistance mechanisms that protect the resulting landomycin D-producing mutant strainS. globisporus LD3 against the toxic action of landomycins were determined.

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This work was partially supported byInternational Association — European Community, European Union’s Member States (INTAS) grant YS 00-208 to the first author andWest-Ukrainian Bio-Medical Research Center grants to the first two authors. Research in Dr. V. Fedorenko’s laboratory was supported by grant BG117b of theMinistry of Science and Education of Ukraine. Prof. J.A. Salas (Universidad de Oviedo, Spain) is acknowledged for providing us with access to HPLC and MALDI-TOF facilities in his laboratory.

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Ostash, B., Kozarevska, I. & Fedorenko, V. Generation of landomycin D-producing strainStreptomyces globisporus LD3. Folia Microbiol 50, 19–23 (2005). https://doi.org/10.1007/BF02931289

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  • DOI: https://doi.org/10.1007/BF02931289

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