Abstract
This study was designed to assess the therapeutic effect ofGinkgo biloba extract (EGb 761) in experimental strnagulation ileus. Rats were divided into control (n=7), placebo (n=11), and EGb-treated (n=11) groups. No surgical procedure was carried out on the control group. Strangulation ileus was produced in the placebo and EGb groups for 2.5 h. At the end of this period, 100 mg/kg EGb in 1 ml of saline was injected intraperitoneally to the EGbtreated group. In the placebo group, animals received an equivalent amount of saline intraperitoneally; 24 h later, repeat laparotomies were performed to take blood and intestinal tissue samples. The EGb treatment decreased tissue malondialdehyde levels and increased catalase activities compared with the placebo group (P<0.05 for both). Serum creatine kinase and phosphorus levels were also determined in all groups. In the placebo group these were significantly higher than in the control group (P<0.01 andP<0.05, respectively). In the EGb group these were not different from controls and the increase in creatine kinase activity in the EGb group was not as high as in the placebo group (P<0.05). Our results suggest that EGb could be preventive against the effects of strangulation ileus in a rat model.
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Çolak, Ö., Şahin, A., Alataş, Ö. et al. The effect ofGinkgo biloba on the activity of catalase and lipid peroxidation in experimental strangulation ileus. Int J Clin Lab Res 28, 69–71 (1998). https://doi.org/10.1007/BF02874083
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DOI: https://doi.org/10.1007/BF02874083