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Gastric Carcinoma

  • Surgical Oncology Forum
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Summary

Gastric cancer continues to be a major global health problem. In the American College of Surgeons Patient Care study on gastric cancer, 5-year disease-specific survival was 26%, with an overall survival of 14%. Improvements in survival will require both earlier diagnosis and new therapeutic strategies. The ability of surgical oncologists to understand the natural history of the disease, accurately define its extent, and provide the most effective treatment places them in a key position to see that improvements in outcome are brought about expeditiously.

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References

  1. Hallissey MT, Allum WH, Jewkes AJ, Ellis DJ, Fielding JW. Early detection of gastric cancer.BMJ 1990;301:513–5.

    CAS  PubMed  Google Scholar 

  2. Parsonnet J, Hansen S, Rodriguez L, et al.Helicobacter pylori infection and gastric lymphoma.N Engl J Med 1994;330:1267–71.

    Article  CAS  PubMed  Google Scholar 

  3. Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negativeHelicobacter pylori infection.Gut 1997;40:297–301.

    CAS  PubMed  Google Scholar 

  4. Blaser MJ, Perez-Perez GI, Kleanthous H, et al. Infection withHelicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach.Cancer Res 1995;55:2111–5.

    CAS  PubMed  Google Scholar 

  5. Luketich JD, Schauer PR, Meltzer CC, et al. Role of positron emission tomography in staging esophageal cancer.Ann Thorac Surg 1997;64:765–9.

    Article  CAS  PubMed  Google Scholar 

  6. Lowy AM, Mansfield PF, Leach SD, Ajani J. Laparoscopic staging for gastric cancer.Surgery 1996;119:611–4.

    CAS  PubMed  Google Scholar 

  7. Burke EC, Karpeh MS, Conlon KC, Brennan MF. Laparoscopy in the management of gastric adenocarcinoma.Ann Surg 1997;225:262–7.

    Article  CAS  PubMed  Google Scholar 

  8. Bonekamp JJ, Songun I, Hermans J, van de Velde CJ. Prognostic value of positive cytology findings from abdominal washings in patients with gastric cancer.Br J Surg 1996;83:672–4.

    Google Scholar 

  9. Gouzi JL, Huguier M, Fagniez PL, et al. Total versus subtotal gastrectomy for adenocarcinoma of the gastric antrum: a French prospective controlled study.Ann Surg 1989;209:162–6.

    CAS  PubMed  Google Scholar 

  10. Bozzetti F, Marubini E, Bonfanti G, et al. Total versus subtotal gastrectomy: surgical morbidity and mortality rates in a multicenter Italian randomized trial (The Italian Gastrointestinal Tumor Study Group).Ann Surg 1997;226:613–20.

    Article  CAS  PubMed  Google Scholar 

  11. Shiu MH, Moore E, Sanders M, et al. Influence of the extent of resection on survival after curative treatment of gastric carcinoma: a retrospective multivariate analysis.Arch Surg 1987;122:1347–51.

    CAS  PubMed  Google Scholar 

  12. Siewert JR, Bottcher K, Roder JD, Busch R, Hermanek P, Meyer HJ. Prognostic relevance of systematic lymph node dissection in gastric carcinoma (German Gastric Carcinoma Study Group).Br J Surg 1993;80:1015–8.

    CAS  PubMed  Google Scholar 

  13. Jaehne J, Meyer HJ, Maschek H, Geerlings H, Burns E, Pichlmayr R. Lymphadenectomy in gastric carcinoma: a prospective and prognostic study.Arch Surg 1992;127:290–4.

    CAS  PubMed  Google Scholar 

  14. Cuschieri A, Fayers P, Fielding J, et al. Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer: preliminary results of the MRC randomised controlled surgical trial (The Surgical Cooperative Group).Lancet 1996;347:995–9.

    Article  CAS  PubMed  Google Scholar 

  15. Bonenkamp JJ, Songun I, Hermans J, et al. Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients.Lancet 1995;345:745–8.

    Article  CAS  PubMed  Google Scholar 

  16. Sasako M, Maruyama K, Kinoshita T, Bonenkamp JJ, van de Velde CJ, Hermans J. Quality control of surgical technique in a multicenter, prospective, randomized, controlled study on the surgical treatment of gastric cancer.Jpn J Clin Oncol 1992;22:41–8.

    CAS  PubMed  Google Scholar 

  17. Maruyama K, Sasako M, Kinoshita T, Sano T, Katai H, Okajima K. Pancreas-preserving total gastrectomy for proximal gastric cancer.World J Surg 1995;19:532–6.

    CAS  PubMed  Google Scholar 

  18. Griffith JP, Sue-Ling HM, Martin I, et al. Preservation of the spleen improves survival after radical surgery for gastric cancer.Gut 1995;36:684–90.

    CAS  PubMed  Google Scholar 

  19. Wanebo HJ, Kennedy BJ, Chmiel J, Steele G Jr, Winchester D, Osteen R. Cancer of the stomach: a patient care study by the American College of Surgeons.Ann Surg 1993;218:583–92.

    CAS  PubMed  Google Scholar 

  20. Roder JD, Bottcher K, Busch R, Wittekind C, Hermanek P, Siewert JR. Classification of regional lymph node metastasis from gastric carcinoma (German Gastric Cancer Study Group).Cancer 1998;82:621–31.

    Article  CAS  PubMed  Google Scholar 

  21. Nakajima T, Ota K, Ishihara S, Oyama S, Nishi M, Hamashima N. Meta-analysis of 10 postoperative adjuvant chemotherapies for gastric cancer in CIH.Gan To Kagaku Ryoho 1994;21:1800–5.

    CAS  PubMed  Google Scholar 

  22. Hermans J, Bonenkamp JJ, Boon MC, et al. Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials.J Clin Oncol 1993;11:1441–7.

    CAS  PubMed  Google Scholar 

  23. Preusser P, Wilke H, Achterrath W, et al. Phase-II-study with EAP (etoposide, adriamycin, cis-platinum) in patients with primary inoperable gastric cancer and advanced disease.Recent Results Cancer Res 1988;110:198–206.

    CAS  PubMed  Google Scholar 

  24. Klein HO. Long-term results with FAMTX (5-fluorouracil, adriamycin, methotrexate) in advanced gastric cancer.Anticancer Res 1989;9:1025–6.

    CAS  PubMed  Google Scholar 

  25. Kelsen D, Atiq OT, Saltz L, et al. FAMTX versus etoposide, doxorubicin, and cisplatin: a random assignment trial in gastric cancer.J Clin Oncol 1992;10:541–8.

    CAS  PubMed  Google Scholar 

  26. Kelsen D. Neoadjuvant therapy for gastrointestinal cancers.Oncology 1993;7:25–32.

    CAS  PubMed  Google Scholar 

  27. Sano T, Sasako M, Kinoshita T, Maruyama K. Recurrence of early gastric cancer: follow-up of 1475 patients and review of the Japanese literature.Cancer 1993;72:3174–8.

    CAS  PubMed  Google Scholar 

  28. Karpeh MS Jr, Brennan MF. Gastric carcinoma counterpoint. In: Johnson FE, Virgo KS, eds.Cancer Patient Follow-up. St. Louis: Mosby, 1997:100–3.

    Google Scholar 

  29. Possik RA, Franco EL, Pires DR, Wohnrath DR, Ferreira EB. Sensitivity, specificity, and predictive value of laparoscopy for the staging of gastric cancer and for the detection of liver metastases.Cancer 1986;58:1–6.

    CAS  PubMed  Google Scholar 

  30. Kriplani AK, Kapur BM. Laparoscopy for pre-operative staging and assessment of operability in gastric carcinoma.Gastrointest Endosc 1991;37:441–3.

    CAS  PubMed  Google Scholar 

  31. O'Brien MG, Fitzgerald EF, Lee G, Crowley M, Shanahan F, O'Sullivan GS. A prospective comparison of laparoscopy and imaging in the staging of esophagogastric cancer before surgery.Am J Gastroenterol 1995;90:2191–4.

    PubMed  Google Scholar 

  32. Stell DA, Carter CR, Stewart I, Anderson JR. Prospective comparison of laparoscopy, ultrasonography and computed tomography in the staging of gastric cancer.Br J Surg 1996;83:1260–2.

    Article  CAS  PubMed  Google Scholar 

  33. Bonavina L, Incarbone R, Lattuada E, Segalin A, Cesana B, Peracchia A. Preoperative laparoscopy in management of patients with carcinoma of the esophagus and of the esophagogastric junction.J Surg Oncol 1997;65:171–4.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Martin S. Karpeh Jr. MD.

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Supported by the Lillian Wells Foundation.

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Karpeh, M.S., Brennan, M.F. Gastric Carcinoma. Annals of Surgical Oncology 5, 650–656 (1998). https://doi.org/10.1007/BF02303836

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  • DOI: https://doi.org/10.1007/BF02303836

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