Abstract
We report a 3-week-old boy with cholestatic hepatitis, most likely due to carbamazepine exposure during pregnancy and breastfeeding. Cholestasis resolved after cessation of nursing. Liver function test results and histological findings were compatible with a drug-induced hepatitis. Other causes were excluded. While carbamazepine-induced hepatitis is well known in children and adults, it has never been described in association with prenatal exposure and/or breast-feeding.
Similar content being viewed by others
References
American Academy of Pediatrics, Committee on Drugs (1989) Transfer of drugs and other chemicals into human milk. Pediatrics 84:924–936
Anonymous (1989) Carbamazepine update. Lancet II:595–597
Briggs GG, Freeman RK, Yaffe SJ (1986) Drugs in pregnancy and lactation. Williams & Wilkins, Baltimore
Davion T, Capron J-P, Andrejak M, Geoffroy P, Capron-Chivrac D, Quénum C (1984) Hépatite aiguë due à la carbamazépine (TégrétolR): étude d'un cas et revue de la littérature. Gastroenterol Clin Biol 8:52–56
Galeone D, Lamontanara G, Torelli D (1985) Acute hepatitis in a patient treated with carbamazepine. J Neurol 232:301–303
Levy M, Goodman MW, Van Dyne BJ, Sumner HW (1981) Granulomatous hepatitis secondary to carbamazepine. Ann Intern Med 95:64–65
Matsukura H, Suzuki Y (1988) A case of hepatitis associated with carbamazepine therapy. Eur J Pediatr 147:666
Mitchell MC, Boitnott JK, Arregui A, Maddrey WC (1981) Granulomatous hepatitis associated with carbamazepine therapy. Am J Med 71:733–735
Pellock JM (1987) Carbamazepine side effects in children and adults. Epilepsia 28 [Suppl 3]:64–70
Rigau Cañardo J, Bruguera M, Sese J, Morlans G (1984) Hépatite aiguë cholestatique due à la carbamazépine. Gastroenterol Clin Biol 8:769–770
Zucker P, Daum F, Cohen MI (1977) Fatal carbamazepine hepatitis. J Pediatr 91:667–668
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Frey, B., Schubiger, G. & Musy, J.P. Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding. Eur J Pediatr 150, 136–138 (1990). https://doi.org/10.1007/BF02072057
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02072057