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Pharmacological approach of a new isoquinoline derivative (458 L)

  • Histamine Metabolism
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Abstract

A new derivative of benzylisoquinoline (458 L) inhibited kidney histidine decarboxylase and decreased the passive anaphylactic bronchospasm in guinea pigs. In rats, the gastric hypersecretion induced by reserpine was inhibited. In mice, the catatonic reactions due to seretonin accumulation were highly reduced.

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References

  1. F. Hahn, H.J. Teschendorf, R. Kreitzchmar, F. Filipowski andK. Somorjai,Zur Frage der antiallergischen Wirkung von Tritoqualine, Arzneim. Forsch. (Drug Res.)20, 1490–1496 (1970).

    Google Scholar 

  2. K.S. Kim andP.A. Shore,Mechanism of Action of Reserpine and Insulin on Gastric Amines and Gastric Acid Secretion and the Effect of Monoamine Oxidase Inhibition, J. Pharmac. exp. Ther.141, 321–326 (1963).

    Google Scholar 

  3. B. Kosmicki, M. Mordelet-Dambrine, P. Lallouette andJ.L. Parrot,Action de la Tritoqualine (554 L sur l'activité de l'histidine décarboxylase non spécifique après injection de 5-hydroxytryptamine, J. Pharmac. (Paris)5, 331–342 (1974).

    Google Scholar 

  4. M. Maccari,Un Nuevo anti istaminico: la Tritoqualina, Arch. Ital. Scien. Farmacol.14, fasc. 3–4, 1–14 (1964).

    Google Scholar 

  5. J.L. Parrot,Inhibition de l'histidine décarboxylase in vivo, Therapie16, 472–484 (1961).

    PubMed  Google Scholar 

  6. J.L. Parrot andC. Laborde,Inhibition of Histidine-Decarboxylase in vivo by Derivatives of the Benzyl-Isoquinoline, in:Ciba Foundation Symposium on Histamine 1955, (Churchill, London 1956), pp. 57–58.

    Google Scholar 

  7. J.L. Parrot andC. Laborde,Inhibition de l'histidine-décarboxylase in vivo par certains dérivés de la benzyl-1-isoquinoleine, J. Physiol. Paris51, 546–547 (1969).

    Google Scholar 

  8. J.L. Parrot, M. Mordelet-Dambrine, H.Y. Cotereau, P. Lallouette andG. Treize,Comparative Studies of the in vivo activity of Tritoqualine and some New Derivatives of Isoquinoline on Non Specific Histidine Decarboxylase. 7th Annual Meeting of Histamine Club, Łódź 1978, May 2–4. Abstracts of papers.

  9. P.A. Shore, A. Burkhalter andV.M. Cohn,A Method for the Fluorometric Assay of Histamine in Tissues. J. Pharmac. exp. Ther.127, 182–186 (1959).

    Google Scholar 

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Authors and Affiliations

  1. C.H.U. Necker-Enfants Malades, Paris

    P. Lallouette, M. Mordelet-Dambrine, G. Treize, V. Trong N'Guyen, A. M. Dubois & J. L. Parrot

  2. Laboratoire de Recherches Biologiques, Levallois-Perret

    P. Lallouette, M. Mordelet-Dambrine, G. Treize, V. Trong N'Guyen, A. M. Dubois & J. L. Parrot

Authors
  1. P. Lallouette
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  2. M. Mordelet-Dambrine
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  3. G. Treize
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  4. V. Trong N'Guyen
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  5. A. M. Dubois
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  6. J. L. Parrot
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Lallouette, P., Mordelet-Dambrine, M., Treize, G. et al. Pharmacological approach of a new isoquinoline derivative (458 L). Agents and Actions 11, 41–43 (1981). https://doi.org/10.1007/BF01991453

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  • DOI: https://doi.org/10.1007/BF01991453

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