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Luteal phase defect and breast cancer genesis

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Summary

The possibility that an unopposed estrogen effect mainly due to a progesterone secretion insufficiency of the corpus luteum might be involved in the promotion of human breast cancer remains a challenging hypothesis (Sherman et al.: Breast Cancer Res Treat 1:287–295, 1981). This review based upon recent data is another approach to this problem, attempting to provide a pathophysiological interpretation of breast cancer risk in terms of luteal phase insufficiency.

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Authors and Affiliations

  1. Department of Reproductive Endocrinology, Faculté de Médecine Necker, 75730, Paris Cedex 15, France

    Pierre Mauvais-Jarvis M.D., Régine Sitruk-Ware M.D. & Frédérique Kuttenn M.D.

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  1. Pierre Mauvais-Jarvis M.D.
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  2. Régine Sitruk-Ware M.D.
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  3. Frédérique Kuttenn M.D.
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Mauvais-Jarvis, P., Sitruk-Ware, R. & Kuttenn, F. Luteal phase defect and breast cancer genesis. Breast Cancer Res Tr 2, 139–150 (1982). https://doi.org/10.1007/BF01806450

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