Summary
Twenty-two patients with meningeal carcinoma due to breast cancer were restrospectively evaluated to determine what prognostic factors affected survival. Five patients survived for more than one year. The therapy in these long-term survivors was similar to that of those suffering early death. Patients with primarily brain symptoms survived a median of 21 days vs. 150 days in those with primarily spinal cord symptoms (p = 0.026). The site of involvement may be an important stratification parameter for future prospective trials.
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References
Little JR, Dale AJD, Okazaki H: Meningeal carcinomatosis: Clinical manifestations. Arch Neurol 30: 138–143, 1974
Olson ME, Chernik NL, Posner JB: Infiltration of the leptomeninges by systemic cancer. A clinical and pathologic study. Arch Neurol 30: 122–137, 1974
Posner JB, Chernik NL: Intracranial metastases from systemic cancer. Adv Neurol 19: 579–592, 1978
Sorensen SC, Eagan RT, Scott M: Meningeal carcinomatosis in patients with primary breast or lung cancer. Mayo Clinic Proc 59: 91–94, 1974
Wasserstrom WR, Glass JP, Posner JB: Diagnosis and treatment of leptomeningeal metastases for solid tumors: Experience with 90 patients. Cancer 49: 759–772, 1982
Shapiro WR, Posner JB, Ushio Y, Chernik NL, Young DF: Treatment of meningeal neoplasms. Cancer Treat Rep 61: 733–743, 1977
Yap HY, Yap BS, Rasmussen S, Levens ME, Hortobagyi GN, Blumenschein GR: Treatment for meningeal carcinomatosis in breast cancer. Cancer 49: 219–222, 1982
Weiss GB, Bunce H, Hokanson JA: Comparing survival of responders and non-responders after treatment: A potential source of confusion in interpreting cancer clinical trials. Controlled Clinical Trials 4: 43–52, 1983
Kaplan EL, Meier P: Non-parametric estimation from incomplete observation. J Am Stat Assoc 53: 457–481, 1958
Lee ET: Statistical Methods for Survival Data Analysis. Lifetime Learning Publications, Belmont CA, 1980, pp 123–126.
Colton T: Statistics in Medicine. Little, Brown, and Co., Boston, 1974, pp 189–217
Bramlet D, Giliberti J, Bender J: Meningeal carcinomatosis. Case report and review of the literature. Neurol 26: 287–290, 1976
Murray JJ, Greco FA, Wolff SN, Hainsworth JF: Neoplastic meningitis. Am J Med 75: 289–294, 1983
Yap BS, Yap HY, Fritsche HA, Blumenschein G, Bodey GP: CSF carcinoembryonic antigen in meningeal carcinomatosis from breast cancer. JAMA 224: 1601–1603, 1980
Wasserstrom WR, Schwartz MK, Fleisher M, Posner JB: Cerebrospinal fluid biochemical markers in central nervous system tumors: A review. Annals Clin Lab Sci 11: 239–251, 1981
Klee GG, Tallman RD, Goellner JR, Yanagihara T: Elevation of carcinoembryonic antigen in cerebrospinal fluid among patients with meningeal carcinomatosis. Mayo Clinic Proc 61: 9–13, 1986
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Supported in part by Clinical Research Center Grant RR59 of the University of Iowa.
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Clamon, G., Doebbeling, B. Meningeal carcinomatosis from breast cancer: Spinal cord vs. brain involvement. Breast Cancer Res Tr 9, 213–217 (1987). https://doi.org/10.1007/BF01806382
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DOI: https://doi.org/10.1007/BF01806382