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Tissue hypoxia

How to detect, how to correct, how to prevent?

  • Consensus Report
  • 3rd European Consensus Conference in Intensive Care Medicine Organized by the Société de Réanimation de Langue Française Co-Sponsored by the American Thoracic Society in Conjunction with the European Society of Intensive Care Medicine
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References

  1. Guidelines for the selection and management of consensus development conferences. Office of medical applications of research. National Institutes of Health, September 1988

  2. Carlet J, Artigas A, Bihari D, Durocher A, Hemmer M, Langer M, Nicolas F, de Rohan Chabot P, Schuster HP, Tenaillon A (1992) The first European Consensus Conference in Intensive Care Medicine: introductory remarks. Intensive Care Med 18:180–181

    Google Scholar 

  3. 3rd European Consensus Conference in Intensive Care, 7–8 December 1995, Paris. Tissue hypoxia: how to detect, how to correct, how to prevent? Réanimation Urgences (1996) 5:161–320

  4. Robin ED (1980) Of men and mitochondria: coping with dysoxia. Am Rev Respir Dis 122:517–531

    Google Scholar 

  5. Hotchkiss RS, Karl IE (1992) Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA 267:1503–1510

    Google Scholar 

  6. Bakker J, Coffemils M, Leon M, Gris P, Vincent IL (1991) Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest 99:956–962

    Google Scholar 

  7. Phang PT, Cunningham KF, Ronco JJ et al (1994) Mathematical coupling explains dependence of oxygen consumption on oxygen delivery in ARDS. Am J Resp Crit Care Med 150:318–323

    Google Scholar 

  8. Ronco JJ, Fenwick JC, Tweedale MG et al (1993) Identification of the critical oxygen delivery for aerobic metabolism in critically ill septic and non-septic humans. JAMA 270:1724–1730

    Google Scholar 

  9. Gutierrez GN, Palizas F, Doglio G et al (1992) Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 339:195–199

    Google Scholar 

  10. Gutierrez G, Brown SD (1995) Gastric tonometry: a new monitoring modality in the intensive care unit. J Intensive Care Med 10:34–44

    Google Scholar 

  11. Hochachka PW (1986) Defense strategies against hypoxia and hypothermia. Science 231:234–242

    Google Scholar 

  12. Hightower LE (1991) Heat shock, stress proteins, chaperones, and proteotoxicity. Cell 66:191–197

    Google Scholar 

  13. Vallet B, Lund N, Curtis SE et al (1994) Gut and muscle tissue PO2 in endotoxemio dogs during shock and resuscitation. J Appl Physiol 76:793–800

    Google Scholar 

  14. Lelli JL, Drongowski RA, Coran AG et al (1992) Hypoxia-induced bacterial translocation in the puppy. J Pediatr Surg 8:974–982

    Google Scholar 

  15. Vary TC, Siegel JH, Nakatani T et al (1986) Effect of sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver. Am J Physiol 250: 634–640

    Google Scholar 

  16. Curtis SE, Cain SM (1992) Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin-treated dogs. Am Rev Respir Dis 145:348–534

    Google Scholar 

  17. Stacpoole PW, Wright EC, Baumgartner TG et al (1992) A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. N Engl J Med 327:1564–1569

    Google Scholar 

  18. Deitch EA (1992) Multiple organ failure: pathophysiology and potential future therapy. Ann Surg 216:117–134

    Google Scholar 

  19. Ruokonen E, Takala J, Kari A, Saxen H, Mertsola J, Hansen EJ (1993) Regional blood flow and oxygen transport in septic shock. Crit Care Med 21:1296–1303

    Google Scholar 

  20. Mancini DM, Bolinger L, Li K, Kendrick K, Chance B, Wilson JR (1994) Validation of near-infrared spectroscopy in humans. J Appl Physiol 77:2740–2747

    Google Scholar 

  21. Clark BJ, Smith D, Chance B (1987) Metabolic consequences of oxygen transport studied with phosphorus nuclear magnetic resonance spectroscopy. In: Bryan-Brown C, Ayres SM (eds) Oxygen transport and utilization. Society of Critical Care Medicine, Fullerton, pp 145–170

    Google Scholar 

  22. Hotchkiss RS, Rust RS, Dence CS et al (1991) Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker (18F) fluoromisonidazole. Am J Physiol 261:R965-R972

    Google Scholar 

  23. Marik PE, Sibbald WJ (1993) Effect of stored blood transfusion on oxygen delivery in patients with sepsis. JAMA 269:3024–3029

    Google Scholar 

  24. Manthous CA, Hall JB, Olson D et al (1995) Effect of cooling on oxygen consumption in febrile critically ill patients. Am J Resp Crit Care Med 151:10–14

    Google Scholar 

  25. Schoemaker WC, Appel PL, Kram HB, Waxman K, Lee TS (1988) Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 94:1176–1186

    Google Scholar 

  26. Boyd O, Grouds M, Bennett ED (1993) A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in highrisk surgical patients. JAMA 270:2699–2707

    Google Scholar 

  27. Berlauk JF, Abrams JH, Gilmour IJ et al (1991) Preoperative optimization of cardiovascular hemodynamics improves outcome in peripheral vascular surgery. Ann Surg 214:289–299

    Google Scholar 

  28. Fleming A, Bishop M, Schoemaker WC et al (1992) Prospective trial of supranormal values as goals of resuscitation in severe trauma. Arch Surg 127:1175–1181

    Google Scholar 

  29. Bishop MH, Shoemaker WC, Appel PL et al (1995) Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma. J Trauma 38:780–787

    Google Scholar 

  30. Tuchschmidt J, Fried J, Astiz M, Rackow E (1992) Elevation of cardiac output and oxygen delivery improves outcome in septic shock. Chest 102:216–220

    Google Scholar 

  31. Yu M, Levy MM, Smith P et al (1993) Effect of maximizing oxygen delivery on morbidity and mortality rates in critically ill patients: a prospective randomized, controlled study. Crit Care Med 21:830–838

    Google Scholar 

  32. Hayes MA, Timmins AC, Yan EHS et al (1994) Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 330:1717–1722

    Google Scholar 

  33. Gattinoni L, Brazzi L, Pelosi P et al (1995) A trial of goal-oriented hemodynamic therapy in critically ill patients. N Engl J Med 333:1025–1032

    Google Scholar 

  34. Russell JA, Phang PT (1994) The oxygen delivery/consumption controversy. Approaches to management of the critically ill. Am J Resp Crit Care Med 149:533–537

    Google Scholar 

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Richard, C. Tissue hypoxia. Intensive Care Med 22, 1250–1257 (1996). https://doi.org/10.1007/BF01709344

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  • DOI: https://doi.org/10.1007/BF01709344

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