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Jaundice associated with nonhepaticStaphylococcus aureus infection

Does teichoic acid have a role in pathogenesis?

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Summary

A previously healthy young man developed jaundice early in the course of a febrile illness caused by an unrecognized deep-seatedStaphylococcus aureus abscess. The serum bilirubin level peaked 11 days before the abscess was discovered and drained. During this time the bilirubin level returned to normal, circulating immune complexes were detected, and the serum free teichoic acid antibody titer was elevated. Indirect immunofluorescent staining of liver tissue for teichoic acid revealed 2+ nuclear fluorescence of the hepatocytes. These findings suggested that circulating free teichoic acid was deposited in the liver and may have had an endotoxin-like effect in the hepatocytes. With the appearance of specific antibody in the serum, circulating teichoic acid was neutralized and further hepatic injury ceased.

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References

  1. Zimmerman HJ, Fang M, Utili R, Seeff LB, Hoofnagle J: Jaundice due to bacterial infection. Gastroenterology 77:362–374, 1979

    PubMed  Google Scholar 

  2. Miller DJ, Keeton GR, Webber BL, Saunders SJ: Jaundice in severe bacterial infection. Gastroenterology 71:94–97, 1976

    PubMed  Google Scholar 

  3. Vermillion SE, Gregg JA, Baggenstoss AH, Bartholomew LG: Jaundice associated with bacteremia. Arch Intern Med 124:611–618, 1969

    PubMed  Google Scholar 

  4. Utili R, Abernathy CO, Zimmerman HJ: Endotoxin effects on the liver. Life Sci 20:553–568, 1977

    PubMed  Google Scholar 

  5. Utili R, Abernathy CO, Zimmerman HJ: Inhibition of Na+, K+-adenosinetriphosphatase by endotoxin: A possible mechanism for endotoxin-induced cholestasis. J Infect Dis 136:583–587, 1977

    PubMed  Google Scholar 

  6. Zlydaszyk JC, Moon RJ: Fate of51Cr-labeled lipopolysaccharide in tissue culture cells and livers of normal mice. Infect Immun 14:100–105, 1976

    PubMed  Google Scholar 

  7. Shands JW: Affinity of endotoxin for membranes. J Infect Dis 128:197–201, 1973

    PubMed  Google Scholar 

  8. Utili R, Abernathy CO, Zimmerman HJ: Studies on the effects ofE. coli endotoxin on canalicular bile formation in the isolated perfused rat liver. J Lab Clin Med 89:471–482, 1977

    PubMed  Google Scholar 

  9. Knox KW, Wicken AJ: Immunological properties of teichoic acids. Bacteriol Rev 37:215–259, 1973

    PubMed  Google Scholar 

  10. Bab IA, Sela MN, Ginsburg I, Dishon T: Inflammatory lesions and bone resorption induced in the rat peridontium by lipoteichoic acid ofStreptococcus mutans. Inflammation 3:345–348, 1979

    PubMed  Google Scholar 

  11. Waltersdorff RL, Fiedel BA, Jackson RW: Induction of nephrocalcinosis in rabbit kidneys after long-term exposure to a streptococcal teichoic acid. Infect Immun 17:665–667, 1977

    PubMed  Google Scholar 

  12. Fiedel BA, Jackson RW: Implication of a streptococcal lipoteichoic acid in renal disfunction in hyperimmunized rabbits. Annual Meeting of the American Society of Microbiology, 1974, p 126 (abstract)

  13. Lentino JR, Rytel MW: Adaptation of enzyme-linked immunosorbent assay (ELISA) to the detection of circulating free and complexed staphylococcal antigen. 20th Interscience Conference on Antimicrobial Agents and Chemotherapy, September 23, 1980, New Orleans, Louisiana

  14. Todd J, Fishaut M, Kapral F, Welch T: Toxic-shock-syndrome associated with phage-group-1 staphylococci. Lancet 2:1116–1118, 1978

    PubMed  Google Scholar 

  15. McKenna UG, Meadows JA, Brewer NS, Wilson WR, Perrault J: Toxic shock syndrome, a newly recognized disease. Mayo Clin Proc 55:663–672, 1980

    PubMed  Google Scholar 

  16. Barnett EV, Knutson DW, Abrass CK, Chia DS, Young LS, Liebling MR: Circulating immune complexes: Their immunochemistry, detection, and importance. Ann Intern Med 91:430–440, 1979

    PubMed  Google Scholar 

  17. Bergdoll MS, Crass BA, Reiser RF, Robbins RN, Davis JP: A new staphylococcal enterotoxin, enterotoxin F, associated with toxic-shock-syndromeStaphylococcus aureus isolates. Lancet 1:1017–1021, 1981

    PubMed  Google Scholar 

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Rose, H.D., Lentino, J.R., Mavrelis, P.G. et al. Jaundice associated with nonhepaticStaphylococcus aureus infection. Digest Dis Sci 27, 1046–1050 (1982). https://doi.org/10.1007/BF01391755

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  • DOI: https://doi.org/10.1007/BF01391755

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