Summary
Vaccines prepared from 75S particles of FMDV, strain A Cruzeiro, although less potent than 146S particle vaccines, conferred immunity to challenge. Heat and acid degraded 75S particles also conferred significant levels of immunity, whereas degraded 146S particle vaccines were ineffective.
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Doel, T.R., Chong, W.K.T. Comparative immunogenicity of 146S, 75S and 12S particles of foot-and-mouth disease virus. Archives of Virology 73, 185–191 (1982). https://doi.org/10.1007/BF01314726
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DOI: https://doi.org/10.1007/BF01314726