Summary
Increases in infectiousness, neurotropism and virulence were found in a laboratory variant of influenza A/Seal/Massachussets/1/80 (H7N7) virus having a highly cleavable hemagglutinin. Sequential passage from host to host further increased pathogenicity of the H7N7 virus in mice, ferrets and rats.
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References
Bean WJ, Hinshaw VS, Webster RG (1981) Genetic characterisation of an avian influenza virus from seals. In: Bishop DHL, Compans RW (eds) The replication of negative-strand viruses. Elsevier/North-Holland, New York, pp 363–367
Bonin J, Scholtissek C (1983) Mouse neurotropic recombinants of influenza A viruses. Arch Virol 75: 255–268
Brown EG (1990) Increased virulence of a mouse-adapted variant of influenza A/FM/1/47 virus is controlled by mutations in genome segments 4,5,7, and 8. J Virol 64: 4523–4533
Herzog S, Rott R (1980) Replication of Borna disease virus in cell cultures. Med Microbiol Immunol 168: 153–158
Kawaoka Y (1991) Equine H7N7 influenza A viruses are highly pathogenic in mice without adaptation: potential use as an animal model. J Virol 65: 3891–3894
Kawaoka Y, Naeve CW, Webster RG (1984) is virulence of H5N2 influenza virus in chickens associated with loss of carbohydrate from the hemagglutinin? Virology 139: 303–316
Klenk H-D, Rott R (1988) The molecular biology of influenza virus pathogenicity. Adv Virus Res 34: 247–281
Li S, Orlich M, Rott R (1990) Generation of seal influenza virus variants pathogenic for chickens, because of hemagglutinin cleavage site changes. J Virol 64: 3297–3303
Reinacher M, Bonin G, Narayan O, Scholtissek C (1983) Pathogenesis of neurovirulent influenza A virus infection in mice. Lab Invest 49: 686–692
Rott R (1992) The pathogenic determinant of influenza virus. Vet Microbiol 33: 303–310
Scholtissek C, Vallbracht A, Flehmig B, Rott R (1979) Correlation of pathogenicity and gene constellation of influenza A viruses. Virology 95: 492–500
Tashiro M, Yamakawa M, Tobita K, Klenk H-D, Rott R, Seto JT (1990) Orgon tropism of Sendai virus in mice: proteloytic activation of the fusion glycoprotein in mouse organs and budding site at the bronchial epithelium. J Virol 64: 3627–3634
Vey M, Orlich M, Adler S, Klenk H-D, Rott R (1992) Hemagglutinin activation of pathogenic avian influenza virus of serotype H7 requires the protease recognition motif R-X-K/R-R. Virology 188: 408–413
Webster RG, Geraci JR, Peturson G (1982) Conjunctivitis in humans exposed to seals infected with influenza virus. N Engl J Med 304: 911
Webster RG, Hinshaw VS, Bean WJ, van Wike KL, Geraci JR, Aubin JS, Peturson G (1981) Characterisation of an influenza virus from seals. Virology 113: 712–724
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Scheiblauer, H., Kendal, A.P. & Rott, R. Pathogenicity of influenza A/Seal/Mass/1/80 virus mutants for mammalian species. Archives of Virology 140, 341–348 (1995). https://doi.org/10.1007/BF01309867
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DOI: https://doi.org/10.1007/BF01309867