Skip to main content
SpringerLink
Log in

Fibrin ring granulomas in hepatitis A

  • Case Report
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Summary

Fibrin ring granuloma is characterized by a fibrinous ring surrounding a central fat vacuole. It has been found in the liver and bone marrow of patients with Q fever, and occasionally with visceral leishmaniasis, cytomegalovirus, Epstein-Barr virus,Staphylococcus epidermidis infections, Hodgkin's lymphoma, and hypersensitivity to allopurinol. We describe a case of serologically confirmed viral hepatitis A with this lesion in the liver biopsy. A false positive anti-hepatitis A virus IgM result has been excluded. This is, to our knowledge, the second reported case of type A hepatitis with hepatic fibrin ring granulomas. It confirms that hepatitis A should be included in the differential diagnosis of this lesion.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bernstein M, Edmondson HA, Barbour BH: The liver lesion in Q fever. Clinical and pathologic features. Arch Intern Med 116:491–498, 1965

    Google Scholar 

  2. Westlake P, Price LM, Russel M, Kelly JK: The pathology of Q fever. J Clin Gastroenterol 9:357–363, 1987

    Google Scholar 

  3. Pellegrin M, Delsol G, Auvergnat JC, Familiades JO, Faure H, Guin M, Voigt JJ: Granulomatous hepatitis in Q fever. Hum Pathol 11:51–57, 1980

    Google Scholar 

  4. Vanderstigel M, Zafrani ES, Lejonc JL, Schaeffer A, Portos JL: Allopurinol hypersensitivity syndrome as a cause of hepatic fibrin ring granulomas. Gastroenterology 90:188–190, 1986

    Google Scholar 

  5. Font J, Bruguera M, Perez Villa F, Ingelmo M: Hepatic fibrin ring granulomas caused byStaphylococcus epidermidis generalized infection. Gastroenterology 93:1449–1452, 1987

    Google Scholar 

  6. Nenert M, Mavier P, Dubuc N, Deforges L, Zafrani ES: Epstein-Barr virus infection and hepatic fibrin ring granulomas. Hum Pathol 19:608–610, 1988

    Google Scholar 

  7. Loldell DH: “Ring” granulomas in cytomegalovirus hepatitis. Arch Pathol Lab Med 111:881–882, 1987

    Google Scholar 

  8. Moreno A, Marazuela M, Yebra M, Hernandez MJ, Hellin T, Montalban C, Vargas JA: Hepatic fibrin ring granulomas in visceral leishmaniasis. Gastroenterology 95:1123–1126, 1988

    Google Scholar 

  9. Ponz E, Garcia Pagan JC, Bruguera M, Bruix J, Rodes J: Hepatic fibrin ring granulomas in a patient with hepatitis A. Gastroenterology 100:268–270, 1991

    Google Scholar 

  10. Gray JR, Steinbrecher HP: False positive anti-hepatitis A virus IgM result in a patient with autoimmune hepatitis. Can J Gastroenterol 3:115–118, 1989

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Médecine interne et gastro-entérologie, Hôpital de Senlis, BP 121, F 60309, Senlis, Cedex, France

    M. Ruel MD, H. Sevestre MD, E. Henry-Biabaud MD, A. M. Courouce PhD, J. P. Capron MD & S. Erlinger MD

  2. Anatomie pathologique, C.H.R.U., F 80054, Amiens, Cedex, France

    M. Ruel MD, H. Sevestre MD, E. Henry-Biabaud MD, A. M. Courouce PhD, J. P. Capron MD & S. Erlinger MD

  3. Institut National de Transfusion sanguine, 6, Rue Alexandre Cabanel, F 75739, Paris, Cedex 15, France

    M. Ruel MD, H. Sevestre MD, E. Henry-Biabaud MD, A. M. Courouce PhD, J. P. Capron MD & S. Erlinger MD

  4. Hépato-gastro-entérologie, C.H.R.U., F 80054, Amiens, Cedex, France

    M. Ruel MD, H. Sevestre MD, E. Henry-Biabaud MD, A. M. Courouce PhD, J. P. Capron MD & S. Erlinger MD

  5. Hépatologie, C.H.U. Beaujon, F 92118, Clichy, Cedex, France

    M. Ruel MD, H. Sevestre MD, E. Henry-Biabaud MD, A. M. Courouce PhD, J. P. Capron MD & S. Erlinger MD

Authors
  1. M. Ruel MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Sevestre MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Henry-Biabaud MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. M. Courouce PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. P. Capron MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Erlinger MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ruel, M., Sevestre, H., Henry-Biabaud, E. et al. Fibrin ring granulomas in hepatitis A. Digest Dis Sci 37, 1915–1917 (1992). https://doi.org/10.1007/BF01308088

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01308088

Key Words

Search

Navigation