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Protooncogenes and growth factors associated with normal and abnormal liver growth

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Abstract

Hepatocyte replication during liver regeneration depends on extrinsic (circulating) and intrinsic (intrahepatic) factors. Two important growth factors produced in the regenerating liver are discussed, TGFα, an autocrine, stimulatory growth factor, and TGFβ, a paracrine inhibitory factor. The balance between the activities of these factors is likely to play an important role in regulating hepatocyte proliferation. The experession of some protooncogenes occurs sequentially during the first few hours after partial hepatectomy and is a marker for the entry of hepatocytes into the cell cycle (proliferative competence). As hepatocytes become competent to proliferate, they respond to TGFα and other growth factors and enter a proliferative phase. It is possible that TGFβ1 serves as a stop signal for liver regeneration but the mechanisms by which TGFβ inhibits hepatocyte DNA synthesis are still unknown.

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  1. Department of Pathology and Laboratory Medicine, Brown University, Box G, 02912, Providence, Rhode Island

    Nelson Fausto

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  1. Nelson Fausto
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Fausto, N. Protooncogenes and growth factors associated with normal and abnormal liver growth. Digest Dis Sci 36, 653–658 (1991). https://doi.org/10.1007/BF01297034

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  • DOI: https://doi.org/10.1007/BF01297034

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