Abstract
Malononitrile reacts with triethyl orthoformate,-orthoacetate,-orthopropionate and-orthobenzoate, resp., in the presence of different amounts of pyridine to ethoxymethylene-malononitriles and pyridinium 1,1,3,3-tetracyano-propenides, resp. The latter can easily be cyclised to 2-amino-6-chloro-3,5-dicyano-(4-alkyl and aryl, resp.)-pyridines. The synthesis of the α-aminopyridines can be carried out as one step reactions starting with malononitrile and orthoformate.
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Werner Schmidt, H., Junek, H. Zur Synthese von Alkoxymethylenmalonitrilen, Tetracyanpropeniden und hochsubstituierten α-Aminopyridinen. Monatshefte für Chemie 108, 895–900 (1977). https://doi.org/10.1007/BF00898055
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DOI: https://doi.org/10.1007/BF00898055