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Type 1 and type 2 immune responses in children: their relevance in juvenile arthritis

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References

  1. Abbas AK, Murphy KM, Sher A (1996) Functional diversity of helper T lymphocytes. Nature 383: 787

    Google Scholar 

  2. Adkins B (1999) T -cell function in newborn mice and humans. Immunol Today 20: 330

    Google Scholar 

  3. Adkins B, Gbanei A, Hamilton K (1993) Developmental regulation of IL-4, IL-2, and IFN-γ production by murine peripheral T lymphocytes. J Immunol 151: 6617

    Google Scholar 

  4. Akbar AN, Terry L, Timms A, Beverley PC, Janossy G (1988) Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J Immunol 140: 2171

    Google Scholar 

  5. Allanore Y, Hilliquin P, Coste J, Renoux M, Menkes CJ (1998) Decreased prevalence of atopy in rheumatoid arthritis. Lancet 351: 497

    Google Scholar 

  6. Allen RC, Armitage RJ, Conley ME, et al (1993) CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 259: 990

    Google Scholar 

  7. Allen RL, Gillespie GM, Hall F, Edmonds S, Hall MA, Wordsworth BP, McMichael AJ, Bowness P (1997) Multiple T cell expansions are found in the blood and synovial fluid of patients with reactive arthritis. J Rheumatol 24: 1750

    Google Scholar 

  8. Austrup F, Vestweber D, Borges E, Lohning M, Brauer R, Herz U, Renz H, Hallmann R, Scheffold A, Radbruch A, Hamann A (1997) P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues. Nature 385: 81

    Google Scholar 

  9. Barrios C, Brandt C, Berney M, Lambert PH, Siegrist CA (1996) Partial correction of the TH2/TH1 imbalance in neonatal murine responses to vaccine antigens through selective adjuvant effects. Eur J Immunol 26: 2666

    Google Scholar 

  10. Bonnecchi R, Bianchi G, Bordignon PP, D'Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A, Sinigaglia F (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187: 129

    Google Scholar 

  11. Brewer EJ Jr, Bass J, Baum J, Cassidy JT, Fink C, Jacobs J, Hanson V, Levinson JE, Schaller J, Stillman JS (1977) Current proposed revision of JRA Criteria. JRA Criteria Subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Section of The Arthritis Foundation. Arthritis Rheum 20: 195

    Google Scholar 

  12. Brugnoni D, Airo P, Graf D, et al (1994) Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the newborn. Eur J Immunol 24: 1919

    Google Scholar 

  13. Burstein HJ, Abbas AK (1993) In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen. J Exp Med 177: 457

    Google Scholar 

  14. Carter LL, Dutton RW (1996) Type 1 and type 2: a fundamental dichotomy for all T -cell subsets. Curr Opin Immunol 8: 336

    Google Scholar 

  15. Chipeta J, Komada Y, Zhang XL, Deguchi T, Sugiyama K, Azuma E, Sakurai M (1998) CD4+ and CD8+ cell cytokine profiles in neonates, older children, and adults: increasing T helper type 1 and T cytotoxic type 1 cell populations with age. Cell Immunol 183: 149

    Google Scholar 

  16. Chuang YH, Chuang BL, Chou CC, Hsieh KH (1996) Different kinds of antigen-presenting cells exert different effects on T-helper cells development. Int Arch Allergy Immunol 111: 366

    Google Scholar 

  17. Cohen SB, Perez-Cruz I, Fallen P, Gluckman E, Madrigal JA (1999) Analysis of the cytokine production by cord and adult blood. Hum Immunol 60: 331

    Google Scholar 

  18. Cookson WO, Moffatt MF (1997) Asthma: an epidemic in the absence of infection? Science 275: 41

    Google Scholar 

  19. Cowdery JS, Chace JH, Yi AK, Krieg AM (1996) Bacterial DNA induces NK cells to produce IFN-γ in vivo and increases the toxicity of lipopolysaccharides. J Immunol 156: 4570

    Google Scholar 

  20. Crawley E, Kay R, Sillibourne J, Patel P, Hutchinson I, Woo P (1999) Polymorphic haplotypes of the interleukin-10 5′ flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum 42: 1101

    Google Scholar 

  21. D'Andrea A, Aste-Amezaga M, Valiante NM, Ma X, Kubin M, Trinchieri G (1993) Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma- production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 178: 1041

    Google Scholar 

  22. De Benedetti F, Pignatti P, Gerloni V, Massa M, Sartirana P, Caporali R, Montecucco CM, Corti A, Fantini F, Martini A (1997) Differences in synovial fluid cytokine levels between juvenile and adult rheumatoid arthritis. J Rheumatol 24: 1403

    Google Scholar 

  23. De Paoli P, Battistin S, Santini GF (1988) Age-related changes in human lymphocyte subsets: progressive reduction of the CD4 CD45R (suppressor inducer) population. Clin Immunol Immunopathol 48: 290

    Google Scholar 

  24. Delespesse G, Yang LP, Ohshima Y, Demeure C, Shu U, Byun DG, Sarfati M (1998) Maturation of human neonatal CD4+ and CD8+ T lymphocytes into Th1/Th2 effectors. Vaccine 16: 1415

    Google Scholar 

  25. Demeure CE, Yang LP, Byun DG, Ishihara H, Vezzio N, Delespesse G (1995) Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions. Eur J Immunol 25: 2722

    Google Scholar 

  26. Donn RP, Ollier WE (1996) Juvenile chronic arthritis a time for change? Eur J Immunogenet 23: 245

    Google Scholar 

  27. Douek IF, Leech NJ, Gillmor HA, Bingley PJ, Gale EA (1999) Children with type-1 diabetes and their unaffected siblings have fewer symptoms of asthma. Lancet 353: 1850

    Google Scholar 

  28. Early E, Reen DJ (1999) Rapid conversion of naive to effector T cell function counteracts diminished primary human newborn T cell responses. Clin Exp Immunol 116: 527

    Google Scholar 

  29. Edmonds J, Morris RI, Metzger AL, Bluestone R, Terasaki PI, Ansell B, Bywaters EG (1974) Follow-up study of juvenile chronic polyarthritis with particular reference to histocompatibility antigen W. 27. Ann Rheum Dis 33: 289

    Google Scholar 

  30. Fishman D, Faulds G, Jeffery R, Mohamed Ali V, Yudkin JS, Humphries S, Woo P (1998) The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 102: 1369

    Google Scholar 

  31. Forte O, Dobloug JH, Natvig JB (1982) Augmented numbers of HLA-DR-positive T lymphocytes in the synovial fluid and synovial tissue of patients with rheumatoid arthritis and juvenile rheumatoid arthritis: in vivo-activated T lymphocytes are potent stimulators in the mixed lymphocyte reaction. Scand J Immunol 15: 227

    Google Scholar 

  32. Forsthuber T, Yip HC, Lehmann PV (1996) Induction of Th1 and Th2 immunity in neonatal mice. Science 271: 1728

    Google Scholar 

  33. Frenkel LM, Nielsen K, Garakian A, Jin R, Wolinsky JS, Cherry JD (1996) A search for persistent rubella virus infection in persons with chronic symptoms after rubella and rubella immunization and in patients with juvenile rheumatoid arthritis. Clin Infect Dis 22: 287

    Google Scholar 

  34. Gate BA, Fasth A (1995) The natural history of juvenile chronic arthritis: a population based cohort study. II. Outcome. J Rheumatol 22: 308

    Google Scholar 

  35. Gattorno M, Facchetti P, Ghiotto F, Vignola S, Buoncompagni A, Prigione I (1997) Synovial fluid T cell clones from oligoarticular juvenile arthritis patients display a prevalent Th1/Th0 pattern of cytokine secretion irrespective of immunophenotype. Clin Exp Immunol 109: 4

    Google Scholar 

  36. Gattorno M, Picco P, Vignola S, Stalla F, Buoncompagni A, Pistoia V (1998) Serum interleukin 12 concentration in juvenile chronic arthritis. Ann Rheum Dis 57: 425

    Google Scholar 

  37. Genain CP, Abel K, Belmar N, Villinger F, Rosenberg DP, Linington C, Raine CS, Hauser SL (1996) Late complications of immune deviation therapy in a nonhuman primate. Science 274: 2054

    Google Scholar 

  38. Gerli R, Bertotto A, Crupi S, Arcangeli C, Marinelli I, Spinozzi F, Cernetti C, Angelella P, Rambotti P (1989) Activation of cord T lymphocytes. I. Evidence for a defective T cell mitogenesis induced through the CD2 molecule. J Immunol 142: 2583

    Google Scholar 

  39. Grewal IS, Xu J, Flavell RA (1995) Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 378: 617

    Google Scholar 

  40. Grom AA, Thompson SD, Luyrink L, Passo M, Choi E, Glass DN (1993) Dominant T-cell-receptor β chain variable region Vβ14+ clones in juvenile rheumatoid arthritis. Proc Natl Acad Sci USA 90: 11104

    Google Scholar 

  41. Gross DM, Steere AC, Huber BT (1998) T helper 1 response is dominant and localized to the synovial fluid in patients with Lyme arthritis. J Immunol 160: 1022

    Google Scholar 

  42. Grun JL, Maurer PH (1989) Different T helper cell subsets elicited in mice utilizing two different adjuvant vehicles: the role of endogenous interleukin 1 in proliferative responses. Cell Immunol 121: 134

    Google Scholar 

  43. Haas JP, Kimura A, Truckenbrodt H, Suschke J, Sasazuki T, Volgger A, Albert ED (1995) Early-onset pauciarticular juvenile chronic arthritis is associated with a mutation in the Y-box of the HLA-DQA1 promoter. Tissue Antigens 45: 317

    Google Scholar 

  44. Hassan J, Reen DJ (1997) Cord blood CD4− CD45RA+ T cells achieve a lower magnitude of activation when compared with their adult counterparts. Immunology 90: 397

    Google Scholar 

  45. Hassan WU, Keaney NP, Holland CD, Kelly CA (1994) Bronchial reactivity and airflow obstruction in rheumatoid arthritis. Ann Rheum Dis 53: 511

    Google Scholar 

  46. Hill R (1975) Juvenile arthritis in various racial groups in British Columbia. Arthritis Rheum 20 (S1): S162

    Google Scholar 

  47. Hoffman RW, O'Sullivan FX, Schafermeyer KR, Moore TL, Roussell D, Watson-McKown R, Kim MF, Wise KS (1997) Mycoplasma infection and rheumatoid arthritis: analysis of their relationship using immunoblotting and an ultrasensitive polymerase chain reaction detection method. Arthritis Rheum 40: 1219

    Google Scholar 

  48. Holt PG (1996) Primary allergic sensitization to environmental antigens: perinatal T cell priming as a determinant of responder phenotype in adulthood. J Exp Med 183: 1297

    Google Scholar 

  49. Hosken NA, Shibuya K, Heath AW, Murphy KM, O'Garra A (1995) The effect of antigen dose on CD4+ T helper cell phenotype development in a TCR-αβ -transgenic model. J Exp Med 182: 1579

    Google Scholar 

  50. Hsieh CS, Heimberger AB, Gold IS, O'Garra A, Murphy KM (1992) Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ TCR transgenic system. Proc Natl Acad Sci USA 89: 6065

    Google Scholar 

  51. Isomaki P, Luukkainen R, Saario R, Toivanen P, Punnonen J (1996) Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium. Arthritis Rheum 39: 386

    Google Scholar 

  52. Joosten LA, Lubberts E, Durez P, Helsen MM, Jacobs MJ, Goldman M, Berg WB van den (1997) Role of IL-4 and IL-10 in murine collagen-induced arthritis. Protective effect of IL-4 and 1L-10 treatment on cartilage destruction. Arthritis Rheum 40: 249

    Google Scholar 

  53. Kageyama Y, Koide Y, Yoshida A, Uchijima M, Arai T, Miyamoto S, Ozeki T, Hiyoshi M, Kushida K, Inoue T (1998) Reduced susceptibility to collagen-induced arthritis in mice deficient in IFN-γ receptor. J Immunol 161: 1542

    Google Scholar 

  54. Kanakoudi-Tsakalidou F, Pardalos G, Pratsidou-Gertsi P, Kansouzidou-Kanakoudi A, Tsangaropoulou-Stinga H (1998) Persistent or severe course of reactive arthritis following Salmonella enteritidis infection. A prospective study of 9 cases. Scand J Rheumatol 27: 431

    Google Scholar 

  55. Kline JN, Waldschmidt TJ, Businga TR, Lemish JE, Weinstock JV, Thorne PS, Krieg AM (1998) Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 160: 2555

    Google Scholar 

  56. Konttinen YT, Bergroth V, Kunnamo I, Haapasaari J (1986) The value of biopsy in patients with monoarticular juvenile rheumatoid arthritis. Arthritis Rheum 29: 47

    Google Scholar 

  57. Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH (1995) B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80: 707

    Google Scholar 

  58. Kunnamo I, Kallio P, Pelkonen P (1986) Incidence of arthritis in urban Finnish children. A prospective study. Arthritis Rheum 29: 1232

    Google Scholar 

  59. Kutukculer N, Caglayan S, Aydogdu F (1998) Study of pro-inflammatory (TNF-α, 1L-1 α, IL-6) and T-cell-derived (IL-2, IL-4) cytokines in plasma and synovial fluid of patients with juvenile chronic arthritis: correlations with clinical and laboratory parameters. Clin Rheumatol 17: 288

    Google Scholar 

  60. Liblau RS, Singer SM, McDevitt HO (1995) Th1 and Th2 CD4+ T cells in the pathogenesis of organspecific autoimmune diseases. Immunol Today 16: 34

    Google Scholar 

  61. Locksley RM (1994) Th2 cells: help for helminths. J Exp Med 179: 1405

    Google Scholar 

  62. MacDonald TT (1999) Effector and regulatory lymphoid cells and cytokines in mucosal sites. Curr Top Microbiol Immunol 236: 113

    Google Scholar 

  63. Mahon BP, Ryan MS, Griffin F, Mills KH (1996) Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1 cells. Infect Immun 64: 5295

    Google Scholar 

  64. Maim MK, Wedderburn LR, Hall F, Wack A, Casorati G, Beverley PCL (1998) A comparison of two techniques for the molecular tracking of specific T cell responses; CD4+ human T cell clones persist in a stable hierarchy but at a lower frequency than clones in the CD8+ population. Immunology 94: 529

    Google Scholar 

  65. Matricardi PM, Rosmini F, Ferrigno L, Nisini R, Rapicetta M, Chionne P, Stroffolini T, Pasquini P, D'Amelio R (1997) Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. Br Med J 314: 999

    Google Scholar 

  66. Mattsson L, Lorentzen JC, Svelander L, Bucht A, Nyman U, Klareskog L, Larsson P (1997) Immunization with alum-collagen II complex suppresses the development of collagen-induced arthritis in rats by deviating the immune response. Scand J Immunol 46: 619

    Google Scholar 

  67. Merkenschlager M, Beverley PC (1989) Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: human CD8 memory CTLp selectively express CD45RO (UCHL1). Int Immunol 1: 450

    Google Scholar 

  68. Moroldo MB, Donnelly P, Saunders J, Glass DN, Giannini EH (1998) Transmission disequilibrium as a test of linkage and association between HLA alleles and pauciarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum 41: 1620

    Google Scholar 

  69. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348

    Google Scholar 

  70. Mosmann TR, Sad S (1996) The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 17: 138

    Google Scholar 

  71. Mosmann TR, Schumacher JH, Street NF, Budd R, O'Garra A, Fong TA, Bond MW, Moore KW, Sher A, Fiorentino DF (1991) Diversity of cytokine synthesis and function of mouse CD4+ T cells. Immunol Rev 123: 209

    Google Scholar 

  72. Muller B, Gimsa U, Mitchison NA, Radbruch A, Sieper J, Yin Z (1998) Modulating the Th1/Th2 balance in inflammatory arthritis. Springer Semin Immunopathol 20: 181

    Google Scholar 

  73. Muller K, Herner EB, Stagg A, Bendtzen K, Woo P (1998) Inflammatory cytokines and cytokine antagonists in whole blood cultures of patients with systemic juvenile chronic arthritis. Br J Rheumatol 37:562

    Google Scholar 

  74. Murray KJ, Thompson SD, Glass DN (1997) Pathogenesis of juvenile chronic arthritis: genetic and environmental factors. Arch Dis Child 77: 530

    Google Scholar 

  75. Murray KJ, Grom AA, Thompson SD, Lieuwen D, Passo MH, Glass DN (1998) Contrasting cytokine profiles in the synovium of different forms of juvenile rheumatoid arthritis and juvenile spondyloarthropathy: prominence of IL-4 in restricted disease. J Rheumatol 25: 1388

    Google Scholar 

  76. Murray KJ, Luyrink L, Grom AA, Passo MH, Emery H, Witte D, Glass DN (1996) Immunohistological characteristics of T cell infiltrates in different forms of childhood onset chronic arthritis. J Rheumatol 23: 2116

    Google Scholar 

  77. Murray KJ, Moroldo MB, Donnelly P (1999) Age specific (susceptibilty and protection) for JRA-associated HLA alleles. Arthritis Rheum 42:1843

    Google Scholar 

  78. Nasert S, Burtchen N, Kussebi F, Millner M, Kroczek R, Jung T, Schwinzer R, Wahn U, Renz H (1996) Stimulation of IgE and IgA production by CD45RA T helper cells in atopic patients. J Immunol 157: 441

    Google Scholar 

  79. Nocton JJ, Miller LC, Tucker LB, Schaller JG (1993) Human parvovirus B19-associated arthritis in children. J Pediatr 122: 186

    Google Scholar 

  80. Nonoyama S, Penix LA, Edwards CP, Lewis DB, Ito S, Aruffo A, Wilson CB, Ochs HD (1995) Diminished expression of CD40 ligand by activated neonatal T cells. J Clin Invest 95: 66

    Google Scholar 

  81. O'Driscoll BR, Milburn HJ, Kemeny DM, Cochrane GM, Panayi GS (1985) Atopy and rheumatoid arthritis. Clin Allergy 15: 547

    Google Scholar 

  82. O'Garra A (1998) Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8: 275

    Google Scholar 

  83. Paul C, Schoenwald U, Truckenbrodt H, Bettinotti MP, Brunnler G, Keller E, Nevinny-Stickel C, Yao Z, Albert ED (1993) HLA-DP/DR interaction in early onset pauciarticular juvenile chronic arthritis. Immunogenetics 37: 442

    Google Scholar 

  84. Peskett SA, Platts-Mills TA, Ansell BM, Stearnes GN (1981) Incidence of atopy in rheumatic disease. J Rheumatol 8: 321

    Google Scholar 

  85. Petty RE, Southwood TR, Baum J, Bhettay E, Glass DN, Manners P, Maldonado-Cocco J, Suarez-Almazor M, Orozco-Alcala J, Prieur AM (1998) Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban, 1997. J Rheumatol 25: 1991

    Google Scholar 

  86. Pilling D, Akbar AN, Bacon PA, Salmon M (1996) CD4+ CD45RA− T cells from adults respond to recall antigens after CD28 ligation. Int Immunol 8: 1737

    Google Scholar 

  87. Pitzalis C, Kingsley G, Haskard D, Panayi G (1988) The preferential accumulation of helper-inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion. Eur J Immunol 18: 1397

    Google Scholar 

  88. Pivetti-Pezzi P (1996) Uveitis in children. Eur J Ophthalmol 6: 293

    Google Scholar 

  89. Ploski R, Vinje O, Ronningen KS, Spurkland A, Sorskaar D, Vandal F, Forre O (1993) HLA class II alleles and heterogeneity of juvenile rheumatoid arthritis. DRB1*0101 may define a novel subset of the disease. Arthritis Rheum 36: 465

    Google Scholar 

  90. Prescott SL, Macaubas C, Holt BJ, Smallacombe TB, Loh R, Sly PD, Holt PG (1998) Transplacemal priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 160: 4730

    Google Scholar 

  91. Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG (1999) Development of allergenspecific T -cell memory in atopic and normal children. Lancet 353: 196

    Google Scholar 

  92. Pritchard MH, Matthews N, Munro J (1988) Antibodies to influenza A in a cluster of children with juvenile chronic arthritis. Br J Rheumatol 27: 176

    Google Scholar 

  93. Pritchard MH, Munro J (1989) Successful treatment of juvenile chronic arthritis with a specific antiviral agent. Br J Rheumatol 28: 521

    Google Scholar 

  94. Rapoport MJ, Jaramillo A, Zipris D, Lazarus AH, Serreze DV, Leiter EH, Cyopick P, Danska JS, Delovitch TL (1993) IL-4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J Exp Med 178: 87

    Google Scholar 

  95. Reiner SL, Locksley RM (1995) The regulation of immunity toLeishmania major. Annu Rev Immunol 13: 151

    Google Scholar 

  96. Ridge JP, Fuchs EJ, Matzinger P (1996) Neonatal tolerance revisited: turning on newborn T cells with dendritlc cells. Science 271: 1723

    Google Scholar 

  97. Rissoan M-C, Soumelis V, Kadowaki N, Grouard G, Briere F, Waal Malefyt Y-J de (1999) Reciprocal control of T helper cell and dendritic cell differentiation. Science 283: 1183

    Google Scholar 

  98. Robinson AT, Miller N, Alexander DR (1993) CD3 antigen-mediated calcium signals and protein kinase C activation are higher in CD45R0+ than in CD45RA+ human T lymphocyte subsets. Eur J Immunol 23: 61

    Google Scholar 

  99. Romagnani S (1991) Human Th1 and Th2 subsets: doubt no more. Immunol Today 12: 256

    Google Scholar 

  100. Rook GA, Stanford JL (1998) Give us this day our daily germs. Immunol Today 19: 113

    Google Scholar 

  101. Rooney M, David J, Symons J, Di Giovine F, Varsani H, Woo P (1995) Inflammatory cytokine responses in juvenile chronic arthritis. Br J Rheumatol 34: 454

    Google Scholar 

  102. Ruperto N, Ravelli A, Levinson JE, Shear ES, Murray K, Link Tague B, Martini A, Glass DN, Giannini EH (1997) Long-term health outcomes and quality of life in American and Italian inception cohorts of patients with juvenile rheumatoid arthritis. II. Early predictors of outcome. J Rheumatol 24: 952

    Google Scholar 

  103. Sad S, Mosmann TR (1994) Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype. J Immunol 153: 3514

    Google Scholar 

  104. Sanders ME, Makgoba MW, Sharrow SO, Stephany D, Springer TA, Young HA, Shaw S (1988) Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-γ production. J Immunol 140: 1401

    Google Scholar 

  105. Schlosstein L, Terasaki PI, Bluestone R, Pearson CM (1973) High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med 288: 704

    Google Scholar 

  106. Schmidt D, Goronzy JJ, Weyand CM (1996) CD4+ CD7− CD28− T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest 97: 2027

    Google Scholar 

  107. Shaheen SO, Aaby P, Hall AJ, Barker DJ, Heyes CB, Shiell AW, Goudiaby A (1996) Measles and atopy in Guinea-Bissau. Lancet 347: 1792

    Google Scholar 

  108. Shaw MK, Lorens JB, Dhawan A, DalCanto R, Tse HY, Tran AB, Bonpane C, Eswaran SL, Brocke S, Sarvemick N, Steinman L, Nolan GP, Fathman CG (1997) Local delivery of IL-4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J Exp Med 185: 1711

    Google Scholar 

  109. Shirakawa T, Enomoto T, Shimazu S, Hopkin JM (1997) The inverse association between tuberculin responses and atopic disorder. Science 275: 77

    Google Scholar 

  110. Silverman ED, Isacovics B, Petsche D, Laxer RM (1993) Synovial fluid cells in juvenile arthritis: evidence of selective T cell migration to inflamed tissue. Clin Exp Immunol 91: 90

    Google Scholar 

  111. Sioud M, Kjeldsen-Kragh J, Suleyman S, Vinje O, Natvig JB, Forre O (1992) Limited heterogeneity of T cell receptor variable region gene usage in juvenile rheumatoid arthritis synovial T cells. Eur J Immunol 22:2413

    Google Scholar 

  112. Spector TD, Hart DJ, Powell RJ (1993) Prevalence of rheumatoid arthritis and rheumatoid factor in women: evidence for a secular decline. Ann Rheum Dis 52: 254

    Google Scholar 

  113. Splawski JB, Nishioka J, Nishioka Y, Lipsky PE (1996) CD40 ligand is expressed and functional on activated neonatal T cells. J Immunol 156: 119

    Google Scholar 

  114. Steinman L (1996) A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. Proc Natl Acad Sci USA 93: 2253

    Google Scholar 

  115. Strachan DP (1999) Lifestyle and atopy. Lancet 353: 1457

    Google Scholar 

  116. Symmons DP, Jones M, Osborne J, Sills J, Southwood TR, Woo P (1996) Paediatric rheumatology in the United Kingdom: data from the British Paediatric Rheumatology Group National Diagnostic Register. J Rheumatol 23: 1975

    Google Scholar 

  117. Tang ML, Kemp AS, Thorburn J, Hill DJ (1994) Reduced interferon-gamma secretion in neonates and subsequent atopy. Lancet 344: 983

    Google Scholar 

  118. Tao X, Constant S, Jorritsma P, Bottomly K (1997) Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation. J Immunol 159: 5956

    Google Scholar 

  119. Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernandez-Sueiro JL, Balish E, Hammer RE (1994) The germfree state prevents development of gut and joint inflammatory disease in HLAB27 transgenic rats. J Exp Med 180: 2359

    Google Scholar 

  120. Thompson SD, Murray KJ, Groin AA, Passo MH, Choi E, Glass DN (1998) Comparative sequence analysis of the human T cell receptor b chain in juvenile rheumatoid arthritis and juvenile spondyloarthropathies. Arthritis Rheum 41: 482

    Google Scholar 

  121. Verhoef CM, Roon JA van, Vianen ME, Bruijnzeel Koomen CA, Lafeber FP, Bijlsma JW (1998) Mutual antagonism of rheumatoid arthritis and hay fever; a role for type 1/type 2 T cell balance. Ann Rheum Dis 57: 275

    Google Scholar 

  122. Vermeire K, Heremans H, Vandeputte M, Huang S, Billiau A, Matthys P (1997) Accelerated collageninduced arthritis in IFN-γ receptor-deficient mice. J Immunol 158: 5507

    Google Scholar 

  123. Von Mutius E, Weiland SK, Fritzsch C, Duhme H, Keil U (1998) Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. Lancet 351: 862

    Google Scholar 

  124. Wack A, Cossarizza A, Heltai S, Barbieri D, D'Addato S, Fransceschi C, Dellabona P, Casorati G (1998) Age-related modifications of the human alphabeta T cell repertoire due to different clonal expansions in the CD4+ and CD8+ subsets. Int Immunol 10: 1281

    Google Scholar 

  125. Wedderburn LR, Robinson N, Patel A, Varsani H, Woo P (1999) Selective recruitment of polarised T cells expressing CCR5 and CXCR3 to the inflamed joints of children with juvenile idiopathic arthritis. Arthritis Rheum (in press)

  126. Wedderburn LR, Maini MK, Patel A, Beverley PCL, Woo P (1999) Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood. Int Immunol 11: 535

    Google Scholar 

  127. Wegmann TG, Lin H, Guilbert L, Mosmann TR (1993) Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 14: 353

    Google Scholar 

  128. Wilkinson NZ, Kingsley GH, Jones HW, Sieper J, Braun J, Ward ME (1999) The detection of DNA from a range of bacterial species in the joints of patients with a variety of arthritides using a nested, broad-range polymerase chain reaction. Rheumatology (Oxford) 38: 260

    Google Scholar 

  129. Wilson CB, Westall J, Johnston L, Lewis DB, Dower SK, Alpert AR (1986) Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies. J Clin Invest 77: 860

    Google Scholar 

  130. Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL, Halter DA (1998) Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature 391: 177

    Google Scholar 

  131. Woo P (1997) The cytokine network in juvenile chronic arthritis. Rheum Dis Clin North Am 23: 491

    Google Scholar 

  132. Wood PN (1978) Nomenclature and classification of arthritis in children. In: Munthe (ed) The care of rheumatic children. EULAR, Basel, p 47

    Google Scholar 

  133. Wu CY, Demeure C, Kiniwa M, Gately M, Delespesse G (1993) 1L-12 induces the production of IFN-γ by neonatal human CD4 T cells. J Immunol 151: 1938

    Google Scholar 

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  1. Department of Molecular Pathology, University College London, Windeyer Institute, 46 Cleveland Street, W1P 6DB, London, UK

    Lucy R. Wedderburn & Patricia Woo

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  1. Lucy R. Wedderburn
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  2. Patricia Woo
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Wedderburn, L.R., Woo, P. Type 1 and type 2 immune responses in children: their relevance in juvenile arthritis. Springer Semin Immunopathol 21, 361–374 (1999). https://doi.org/10.1007/BF00812262

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