Summary
In Part I, assumptions made in the construction of pharmacokinetic models and the solutions derived from them are discussed. It is shown that, under certain conditions, the drug in any compartment of a general model can be described by a sum of exponentials, where the exponents are the eigenvalues and the factors the components of the eigenvectors of the kinetic matrix. In Part II proof is presented that Dost's Law of corresponding areas is universally valid for any compartment model if linear processes are assumed to occur. Two practical examples are analysed.
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Nüesch, E. Proof of the general validity of Dost's law of corresponding areas. Eur J Clin Pharmacol 6, 33–43 (1973). https://doi.org/10.1007/BF00561799
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DOI: https://doi.org/10.1007/BF00561799